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57/100

✓ Peer-reviewed alzhub usefulness score 57 out of 100. Tau biomarkers

Topic: Amyloid, tau and blood-test diagnosis

Plain-language summary

Importance Subjective cognitive decline (SCD) may be an early indicator of Alzheimer disease and related dementias (ADRD), yet its association with plasma biomarkers remains unclear among middle-aged and older adults (aged 50-86 years). Objective To examine associations between plasma biomarkers of amyloid, tau, neuroaxonal damage, and glial activation with SCD in a heterogeneous cohort of Hispanic and/or Latino adults. Design, setting, and participants This cross-sectional study used survey-weighted data from the Study of Latinos-Investigation of Neurocognitive Aging, an ancillary study of the Hispanic Community Health Study/Study of Latinos.

What this study adds

Evidence grade: Moderate

This is a cross-sectional study of 5,712 participants. This cross-sectional study examined associations between several plasma biomarkers and subjective cognitive decline in middle-aged and older Hispanic and/or Latino adults. Reported effect size: 53.92%.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Márquez, F., Tarraf, W., Gonzalez, K., Valencia, D. F., Stickel, A. M., Anita, N. Z., et al. (2025). Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults. JAMA network open. https://doi.org/10.1001/jamanetworkopen.2025.31038

Vancouver

Márquez F, Tarraf W, Gonzalez K, Valencia DF, Stickel AM, Anita NZ, et al. Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults. JAMA network open. 2025. doi:10.1001/jamanetworkopen.2025.31038. PMID: 40911305.

BibTeX

@article{marquez2025-40911305,
  author  = {Márquez, F. and Tarraf, W. and Gonzalez, K. and Valencia, D. F. and Stickel, A. M. and Anita, N. Z. and Sotres-Alvarez, D. and Levin, B. E. and others},
  title   = {{Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults}},
  journal = {JAMA network open},
  year    = {2025},
  doi     = {10.1001/jamanetworkopen.2025.31038},
  pmid    = {40911305},
  url     = {https://doi.org/10.1001/jamanetworkopen.2025.31038}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

How to read this study

Design: this is a cross-sectional study. Everyone is measured once, so it cannot show which came first. Read it as a snapshot of how two things go together at one moment.
Size: the record lists 5,712 participants. Ask whether that is enough for the question, and who they were.
Effect: the record reports “53.92%”. A statistically significant result can still be small in daily life.

What the evidence grade means here

This page is graded moderate. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Moderate means the abstract mentions a cohort, case-control or longitudinal design. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

New to reading papers? Six questions to ask of any Alzheimer’s study · how we score.

Key findings

Objective To examine associations between plasma biomarkers of amyloid, tau, neuroaxonal damage, and glial activation with SCD in a heterogeneous cohort of Hispanic and/or Latino adults.
Design, setting, and participants This cross-sectional study used survey-weighted data from the Study of Latinos-Investigation of Neurocognitive Aging, an ancillary study of the Hispanic Community Health Study/Study of Latinos.
Participants were aged 50 to 86 years and resided in 4 major US cities.
Data were collected from 2016 to 2018 and analyzed between December 2024 and June 2025.

Why it matters

This cross-sectional study examined associations between several plasma biomarkers and subjective cognitive decline in middle-aged and older Hispanic and/or Latino adults. It is about biomarker associations with a self-reported symptom, not about treating, curing or preventing Alzheimer's disease.

New to this subject? Start with our plain-English guide: Blood tests & biomarkers →

Study details

Study designcross-sectional
Participants5,712
Effect size53.92%
Evidence strengthModerate

How this study scored 57/100

Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA network open)
Journal's citation record	2 / 4	JAMA Network Open: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	3 / 4	5,712 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 8 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	2.7 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 5.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Héctor M. González: h-index 28 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California San Diego: institution h-index 1,852 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 8 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40911305)
Free to read	2 / 2	Free to read
Total	57 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

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