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A Biomarker-Based Classification of Corticobasal Syndrome
Carla Palleis, Alexander Maximilian Bernhardt, Endy Weidinger, Urban M Fietzek, Alexander Jäck, Sabrina Katzdobler, Johannes Gnörich, Theresa Bauer et al.. Movement disorders : official journal of the Movement Disorder Society, 2025-10-06
Topic: Plasma and spinal-fluid biomarkers
Tau positivity was found in 90% of CBS cases, Aβ in 28%, and αSyn in 24%. Stratification identified: 52% consistent with tau-predominant pathology, 18% with AD, 10% with AD+LTS, 10% with tau-predominant+LTS, 4% with isolated LTS, and 6% unclassified. αSyn positivity was more frequent in AD-CBS (36%) than in tau-predominant-CBS (16%). Aβ-positive cases showed greater cognitive impairment; Tau positivity correlated with worse motor symptoms; αSyn-positive patients had milder motor symptoms, slower progression, and lower NfL levels. CBS is molecularly heterogeneous. Biomarker-based classification may enhance diagnostic precision and support personalized therapeutic strategies. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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APA 7th
Palleis, C., Bernhardt, A. M., Weidinger, E., Fietzek, U. M., Jäck, A., Katzdobler, S., et al. (2026). A Biomarker-Based Classification of Corticobasal Syndrome. Movement disorders : official journal of the Movement Disorder Society. https://doi.org/10.1002/mds.70070
Vancouver
Palleis C, Bernhardt AM, Weidinger E, Fietzek UM, Jäck A, Katzdobler S, et al. A Biomarker-Based Classification of Corticobasal Syndrome. Movement disorders : official journal of the Movement Disorder Society. 2026. doi:10.1002/mds.70070. PMID: 41048081.
BibTeX
@article{palleis2026-41048081,
author = {Palleis, Carla and Bernhardt, Alexander Maximilian and Weidinger, Endy and Fietzek, Urban M and Jäck, Alexander and Katzdobler, Sabrina and Gnörich, Johannes and Bauer, Theresa and others},
title = {{A Biomarker-Based Classification of Corticobasal Syndrome}},
journal = {Movement disorders : official journal of the Movement Disorder Society},
year = {2026},
doi = {10.1002/mds.70070},
pmid = {41048081},
url = {https://doi.org/10.1002/mds.70070}
}
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Key findings
- Tau positivity was found in 90% of CBS cases, Aβ in 28%, and αSyn in 24%.
- Stratification identified: 52% consistent with tau-predominant pathology, 18% with AD, 10% with AD+LTS, 10% with tau-predominant+LTS, 4% with isolated LTS, and 6% unclassified. αSyn positivity was more frequent in AD-CBS (36%) than in tau-predominant-CBS (16%).
- Aβ-positive cases showed greater cognitive impairment; Tau positivity correlated with worse motor symptoms; αSyn-positive patients had milder motor symptoms, slower progression, and lower NfL levels.
- Biomarker-based classification may enhance diagnostic precision and support personalized therapeutic strategies. © 2025 The Author(s).
- Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 61/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 34 of the 56 points we could judge it on, which is 61 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Movement disorders : official journal of the Movement Disorder Society) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41048081) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 34 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 34 of the 56 points we could judge it on is 61 out of 100. |
| Total | 61 / 100 | — |
What each of these 20 components measures, and what this score is not →
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