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Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans
Dickson DW, Davies P, Bevona C, Van Hoeven KH, Factor SM, Grober E, Aronson MK, Crystal HA.. Acta neuropathologica, 1994-01-01
Topic: Risk, prevention and care in population studies
In a neuropathological study of 81 brains of prospectively studied subjects of 80 years of age or older at the time of death, 13 cases (16%), including 4 men and 9 women, had hippocampal sclerosis (HpScl) affecting the vulnerable region of the hippocampus. In demented subjects of 80 years of age or older, the frequency of HpScl was even higher, 26%. Cases with HpScl had significantly fewer hippocampal senile plaques (SP) and neurofibrillary tangles (NFT) and parahippocampal NFT than cases without HpScl, but did not differ significantly in any of the other measured pathological parameters.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Dickson, D. W., Davies, P., Bevona, C., Van Hoeven, K. H., Factor, S. M., Grober, E., et al. (1994). Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans. Acta neuropathologica. https://doi.org/10.1007/bf00293396
Vancouver
Dickson DW, Davies P, Bevona C, Van Hoeven KH, Factor SM, Grober E, et al. Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans. Acta neuropathologica. 1994. doi:10.1007/bf00293396. PMID: 7810292.
BibTeX
@article{dickson1994-7810292,
author = {Dickson, D. W. and Davies, P. and Bevona, C. and Van Hoeven, K. H. and Factor, S. M. and Grober, E. and Aronson, M. K. and Crystal, H. A.},
title = {{Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans}},
journal = {Acta neuropathologica},
year = {1994},
doi = {10.1007/bf00293396},
pmid = {7810292},
url = {https://doi.org/10.1007/bf00293396}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- In demented subjects of 80 years of age or older, the frequency of HpScl was even higher, 26%.
- Cases with HpScl had significantly fewer hippocampal senile plaques (SP) and neurofibrillary tangles (NFT) and parahippocampal NFT than cases without HpScl, but did not differ significantly in any of the other measured pathological parameters.
- Enzyme-linked analysis of synaptic protein immunoreactivity in a subset of 33 cases demonstrated significant decreases in the hippocampus, but not in frontal, temporal, parietal or parahippocampal cortices.
- All but 1 of the cases with HpScl had Blessed information, memory and concentration scores (BIMC) of 8 or more, and all were considered to be demented.
Why it matters
This neuropathological study found hippocampal sclerosis in 16% of brains from people aged 80 or older and in 26% of demented subjects in that age group. It describes a pathological feature and does not test any treatment or cure.
Study details
- Evidence strengthLow
How this study scored 46/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Acta neuropathologica) |
| Journal's citation record | 3 / 4 | Acta Neuropathologica: journal h-index 287 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1994 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 294 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.6 citations a year over 34 year(s) since 1994 |
| Impact for its field and year | 3 / 6 | Cited 4.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 31 other studies in this library |
| Still being cited | 2 / 4 | Cited 29 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Howard Crystal: h-index 38 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Albert Einstein College of Medicine: institution h-index 973 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 7810292) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 46 / 100 | — |
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