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Assessment of cognitive decline associated with aging: a comparison of individuals with Down syndrome and other etiologies
Das JP, Mishra RK.. Research in developmental disabilities, 1995-01-01
Topic: Risk, prevention and care in population studies
Cognitive processes and their decline with aging were studied in individuals with Down Syndrome (DS) and individuals of comparable mental handicap without Down Syndrome (NonDS). The cognitive processes were measured by tests of Planning, Attention, Simultaneous, and Successive processing. The DS and NonDS samples were divided into age groups of 26-40 years (DS = 23, NonDS = 23) and 41-60 years (DS = 8, NonDS = 18). Analyses of variance using factor scores demonstrated articulation to be significantly poorer in the DS sample at and above 40 years. Specifically, the tests that showed the interaction effects between DS/NonDS and the two age groups were Number Finding, Expressive Attention, and Speech Rate. When the cutoff age was raised to 50 years, an additional Attention and Planning task (Receptive Attention and Matching Numbers) also showed the interaction effect. These tests hold the promise for diagnosing early signs of dementia of Alzheimer type. Implications for rehabilitation are described.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Das, J. P., & Mishra, R. K. (1995). Assessment of cognitive decline associated with aging: a comparison of individuals with Down syndrome and other etiologies. Research in developmental disabilities. https://doi.org/10.1016/0891-4222(94)00032-5
Vancouver
Das JP, Mishra RK. Assessment of cognitive decline associated with aging: a comparison of individuals with Down syndrome and other etiologies. Research in developmental disabilities. 1995. doi:10.1016/0891-4222(94)00032-5. PMID: 7701089.
BibTeX
@article{das1995-7701089,
author = {Das, J. P. and Mishra, R. K.},
title = {{Assessment of cognitive decline associated with aging: a comparison of individuals with Down syndrome and other etiologies}},
journal = {Research in developmental disabilities},
year = {1995},
doi = {10.1016/0891-4222(94)00032-5},
pmid = {7701089},
url = {https://doi.org/10.1016/0891-4222(94)00032-5}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Analyses of variance using factor scores demonstrated articulation to be significantly poorer in the DS sample at and above 40 years.
Why it matters
Some cognitive tests showed poorer performance in people with Down syndrome at and above 40 years, and the authors say these tests hold promise for diagnosing early signs of Alzheimer-type dementia. This is about assessment and diagnosis, not about treating, curing, or preventing the disease.
Study details
- Evidence strengthLow
How this study scored 32/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 31 of the 96 points we could judge it on, which is 32 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Research in developmental disabilities) |
| Journal's citation record | 2 / 4 | Research in Developmental Disabilities: journal h-index 158 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1995 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 42 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.3 citations a year over 33 year(s) since 1995 |
| Impact for its field and year | 2 / 6 | Cited 2.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 1 / 3 | University of Alberta: institution h-index 1,174 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 7701089) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 31 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 31 of the 96 points we could judge it on is 32 out of 100. |
| Total | 32 / 100 | — |
What each of these 20 components measures, and what this score is not →
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