Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
Kelly R. Bales, Tatyana Verina, Richard C. Dodel, Yansheng Du, Larry D. Altstiel, Mark H. Bender, Paul A. Hyslop, Edward M. Johnstone, Sheila P. Little, David J. Cummins, Pedro Piccardo, Bernardino Francesco Ghetti, Steven M. Paul. Nature Genetics, 1997-11-01
Topic: Brain proteins, microglia and lab models
We do not hold a plain-English summary of this study yet. Use the links to the original below for its abstract and findings.
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APA 7th
Bales, K. R., Verina, T., Dodel, R. C., Du, Y., Altstiel, L. D., Bender, M. H., et al. (1997). Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nature Genetics. https://doi.org/10.1038/ng1197-263
Vancouver
Bales KR, Verina T, Dodel RC, Du Y, Altstiel LD, Bender MH, et al. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nature Genetics. 1997. doi:10.1038/ng1197-263. PMID: 9354781.
BibTeX
@article{bales1997-9354781,
author = {Bales, Kelly R. and Verina, Tatyana and Dodel, Richard C. and Du, Yansheng and Altstiel, Larry D. and Bender, Mark H. and Hyslop, Paul A. and Johnstone, Edward M. and Little, Sheila P. and Cummins, David J. and Piccardo, Pedro and Ghetti, Bernardino Francesco and Paul, Steven M.},
title = {{Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition}},
journal = {Nature Genetics},
year = {1997},
doi = {10.1038/ng1197-263},
pmid = {9354781},
url = {https://doi.org/10.1038/ng1197-263}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 13 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Why it matters
Reports that lacking apolipoprotein E dramatically reduces amyloid β-peptide deposition.
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How this study scored 51/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 48 of the 95 points we could judge it on, which is 51 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Nature Genetics) |
| Journal's citation record | 4 / 4 | Nature Genetics: journal h-index 776 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1997 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 831 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 26.8 citations a year over 31 year(s) since 1997 |
| Impact for its field and year | 5 / 6 | Cited 25.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 46 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Steven M. Paul: h-index 81 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Indiana University School of Medicine: institution h-index 784 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 9354781) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 48 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 48 of the 95 points we could judge it on is 51 out of 100. |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
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