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Multiple neurological abnormalities in mice deficient in the G protein Go
Jiang M, Gold MS, Boulay G, Spicher K, Peyton M, Brabet P, Srinivasan Y, Rudolph U et al.. Proceedings of the National Academy of Sciences of the United States of America, 1998-03-01
Topic: Brain proteins, microglia and lab models
The G protein Go is highly expressed in neurons and mediates effects of a group of rhodopsin-like receptors that includes the opioid, alpha2-adrenergic, M2 muscarinic, and somatostatin receptors. In vitro, Go is also activated by growth cone-associated protein of Mr 43,000 (GAP43) and the Alzheimer amyloid precursor protein, but it is not known whether this occurs in intact cells. To learn about the roles that Go may play in intact cells and whole body homeostasis, we disrupted the gene encoding the alpha subunits of Go in embryonic stem cells and derived Go-deficient mice.
Key findings
- In vitro, Go is also activated by growth cone-associated protein of Mr 43,000 (GAP43) and the Alzheimer amyloid precursor protein, but it is not known whether this occurs in intact cells.
- To learn about the roles that Go may play in intact cells and whole body homeostasis, we disrupted the gene encoding the alpha subunits of Go in embryonic stem cells and derived Go-deficient mice.
- Mice with a disrupted alphao gene (alphao-/- mice) lived but had an average half-life of only about 7 weeks.
- No Goalpha was detectable in homogenates of alphao-/- mice by ADP-ribosylation with pertussis toxin.
Why it matters
This study created mice lacking the G protein Go, which can be activated by the Alzheimer amyloid precursor protein in vitro, and found the mice had multiple neurological abnormalities and a short half-life of about 7 weeks. It is animal research and does not test any treatment, cure, or prevention of Alzheimer's disease.
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Study details
- Effect sizedecreased by 30%
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Proceedings of the National Academy of Sciences of the United States of America) |
| Journal's citation record | 4 / 4 | Proceedings of the National Academy of Sciences: journal h-index 1,167 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1998 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mice”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 220 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.3 citations a year over 30 year(s) since 1998 |
| Impact for its field and year | 3 / 6 | Cited 3.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Lutz Birnbaumer: h-index 124 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Centre National de la Recherche Scientifique: institution h-index 2,511 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 9501252) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
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Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Jiang, M., Gold, M. S., Boulay, G., Spicher, K., Peyton, M., Brabet, P., et al. (1998). Multiple neurological abnormalities in mice deficient in the G protein Go. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.95.6.3269
Vancouver
Jiang M, Gold MS, Boulay G, Spicher K, Peyton M, Brabet P, et al. Multiple neurological abnormalities in mice deficient in the G protein Go. Proceedings of the National Academy of Sciences of the United States of America. 1998. doi:10.1073/pnas.95.6.3269. PMID: 9501252.
BibTeX
@article{jiang1998-9501252,
author = {Jiang, M. and Gold, M. S. and Boulay, G. and Spicher, K. and Peyton, M. and Brabet, P. and Srinivasan, Y. and Rudolph, U. and others},
title = {{Multiple neurological abnormalities in mice deficient in the G protein Go}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {1998},
doi = {10.1073/pnas.95.6.3269},
pmid = {9501252},
url = {https://doi.org/10.1073/pnas.95.6.3269}
}