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Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck, Huiyi Miao, Monica C. Tory, Adele M. Pauley, John R. Brashler, Nancy C. Stratman, W. Rodney Mathews, Allen E. Buhl, Donald B. Carter, Alfredo G. Tomasselli, Luis A. Parodi, Robert L. Heinrikson, Mark E. Gurney. Nature, 1999-12-01
Topic: Amyloid, tau and blood-test diagnosis
We do not hold a plain-English summary of this study yet. Use the links to the original below for its abstract and findings.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., et al. (1999). Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity. Nature. https://doi.org/10.1038/990107
Vancouver
Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, et al. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity. Nature. 1999. doi:10.1038/990107. PMID: 10591213.
BibTeX
@article{yan1999-10591213,
author = {Yan, Riqiang and Bienkowski, Michael J. and Shuck, Mary E. and Miao, Huiyi and Tory, Monica C. and Pauley, Adele M. and Brashler, John R. and Stratman, Nancy C. and Mathews, W. Rodney and Buhl, Allen E. and Carter, Donald B. and Tomasselli, Alfredo G. and Parodi, Luis A. and Heinrikson, Robert L. and Gurney, Mark E.},
title = {{Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity}},
journal = {Nature},
year = {1999},
doi = {10.1038/990107},
pmid = {10591213},
url = {https://doi.org/10.1038/990107}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 15 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Why it matters
Reports a membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity.
How this study scored 52/100
Published in a top-tier journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on strength of evidence and institution's track record, so those were left out: it earned 48 of the 92 points we could judge it on, which is 52 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 10 / 10 | Tier 1 — top-tier general journal (Nature) |
| Journal's citation record | 4 / 4 | Nature: journal h-index 1,841 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1999 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,440 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 49.7 citations a year over 29 year(s) since 1999 |
| Impact for its field and year | 6 / 6 | Cited 45.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Mark E. Gurney: h-index 41 (OpenAlex, whole career) |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 10591213) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 48 / 92 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 48 of the 92 points we could judge it on is 52 out of 100. |
| Total | 52 / 100 | — |
What each of these 20 components measures, and what this score is not →
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