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Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease: a pilot study
Iddon JL, Pickard JD, Cross JJ, Griffiths PD, Czosnyka M, Sahakian BJ.. Journal of neurology, neurosurgery, and psychiatry, 1999-12-01
Topic: Risk, prevention and care in population studies
Objectives Eleven patients with idiopathic normal pressure hydrocephalus (NPH) were selected from an initial cohort of 43 patients. The patients with NPH fell into two distinctive subgroups: preshunt, group 1 (n=5) scored less than 24 on the mini mental state examination (MMSE) and were classified as demented and group 2 (n=6) scored 24 or above on the MMSE and were classified as non-demented. Methods All patients were neuropsychologically assessed on two occasions: preshunt and then again 6 months postshunt.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Iddon, J. L., Pickard, J. D., Cross, J. J., Griffiths, P. D., Czosnyka, M., & Sahakian, B. J. (1999). Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease: a pilot study. Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp.67.6.723
Vancouver
Iddon JL, Pickard JD, Cross JJ, Griffiths PD, Czosnyka M, Sahakian BJ. Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease: a pilot study. Journal of neurology, neurosurgery, and psychiatry. 1999. doi:10.1136/jnnp.67.6.723. PMID: 10567486.
BibTeX
@article{iddon1999-10567486,
author = {Iddon, J. L. and Pickard, J. D. and Cross, J. J. and Griffiths, P. D. and Czosnyka, M. and Sahakian, B. J.},
title = {{Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease: a pilot study}},
journal = {Journal of neurology, neurosurgery, and psychiatry},
year = {1999},
doi = {10.1136/jnnp.67.6.723},
pmid = {10567486},
url = {https://doi.org/10.1136/jnnp.67.6.723}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- The patients with NPH fell into two distinctive subgroups: preshunt, group 1 (n=5) scored less than 24 on the mini mental state examination (MMSE) and were classified as demented and group 2 (n=6) scored 24 or above on the MMSE and were classified as non-demented.
- Methods All patients were neuropsychologically assessed on two occasions: preshunt and then again 6 months postshunt.
- Group 1 completed the mini mental state examination (MMSE) and the Kendrick object learning test (KOLT).
- In addition to the MMSE and KOLT, group 2 completed further tasks including verbal fluency and memory and attentional tasks from the CANTAB battery.
Why it matters
This small pilot study compared cognitive test patterns in 11 patients with normal pressure hydrocephalus and patients with Alzheimer's disease. It is a preliminary comparison of two different conditions and does not test any treatment, cure, or prevention for Alzheimer's disease.
Study details
- Participants43
- Evidence strengthModerate
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurology, neurosurgery, and psychiatry) |
| Journal's citation record | 3 / 4 | Journal of Neurology Neurosurgery & Psychiatry: journal h-index 336 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1999 — older than 20 years, still counted |
| Sample size | 1 / 4 | 43 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 228 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.9 citations a year over 29 year(s) since 1999 |
| Impact for its field and year | 1 / 6 | Cited 0.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 25 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Barbara Jacquelyn Sahakian: h-index 152 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Cambridge: institution h-index 1,973 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 10567486) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1136/jnnp.67.6.723
- PubMed: 10567486
- Original source →
- Free full text: Journal of Neurology Neurosurgery & Psychiatry →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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