Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,751–26,775 of 27,380 studies, newest first · page 1071 of 1096.
September 1993 7
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1993-09-01
MRI hippocampal volumes and memory function before and after temporal lobectomy
40/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology
Key finding: In LTL patients, the difference (right minus left hippocampal volume) between hippocampal volumes (DHF) was significantly (p < 0.001) correlated (r = 0.61) with postoperative verbal memory change as measured by a delayed memory percent retention score from the Wechsler Memory Scale-Revised, Logical Memory subtest. +3 more findings
Full summary, score breakdown and related studies → Original source
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1993-09-01
Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: There was no significant effect of the location (dorsal or ventral) of damage to the overlying neocortex only. +1 more finding
Full summary, score breakdown and related studies → Original source
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1993-09-01
Cerebral white matter changes in acquired immunodeficiency syndrome dementia: alterations of the blood-brain barrier
51/100 ✓ Peer-reviewed Brain tissue and pathology Annals of neurology
Key finding: To investigate the pathological basis of these white matter abnormalities, we performed an immunocytochemical and histological analysis of subcortical white matter from AIDS patients with and without dementia, from pre-AIDS patients (asymptomatic HIV-seropositive patients), and from HIV-seronegative control subjects. +3 more findings
Full summary, score breakdown and related studies → Original source
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1993-09-01
Phosphoprotein phosphatase activities in Alzheimer disease brain
46/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neurochemistry
Key finding: Our previous studies demonstrated that abnormally phosphorylated tau could be dephosphorylated after treatment with alkaline phosphatase, thereby suggesting that the abnormal phosphorylation of tau might in part be the result of a deficiency of the phosphoprotein phosphatase system in patients with Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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1993-09-01
A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics
65/100 ✓ Peer-reviewed How common it is Annals of internal medicine
Key finding: Delirium developed in 27 of 107 patients (25%) in the development cohort.
Full summary, score breakdown and related studies → Original source
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1993-09-01
Effects of medication on parotid salivary flow rates in an individual with dementia of the Alzheimer type
48/100 ✓ Peer-reviewed Treatments Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
Key finding: We measured unstimulated and stimulated parotid salivary flow rates associated with the drug therapies. +2 more findings
Full summary, score breakdown and related studies → Original source
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1993-09-01
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease
54/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America
Key finding: Late-onset familial and sporadic Alzheimer disease patients have an increased frequency of one of the three common apoE alleles, epsilon 4, suggesting apoE4 is associated with increased susceptibility to disease. +2 more findings
Full summary, score breakdown and related studies → Original source
August 1993 6
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1993-08-13
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
63/100 ✓ Peer-reviewed Genetics Science
Key finding: The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
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1993-08-01
Heightened synaptic plasticity of hippocampal CA1 neurons during a cholinergically induced rhythmic state
41/100 ✓ Peer-reviewed Disease mechanisms Nature
Key finding: The results suggest that cholinergic systems may affect memory formation through the induction of an oscillatory state in which the requirements for synaptic plasticity are dramatically altered.
Full summary, score breakdown and related studies → Original source
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1993-08-01
Clinical trial of indomethacin in Alzheimer's disease
50/100 ✓ Peer-reviewed Clinical trials Neurology
Key finding: Over a battery of cognitive tests, indomethacin patients improved 1.3% (+/- 1.8%), whereas placebo patients declined 8.4% (+/- 2.3%)--a significant difference (p < 0.003).
Full summary, score breakdown and related studies → Original source
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1993-08-01
Functional roles of microglia in the brain
36/100 ✓ Peer-reviewed Inflammation and the immune system Neuroscience research
Key finding: It has been suggested that microglia, a type of glial cells in the central nervous system, play various important roles in normal and pathologic brains. +1 more finding
Full summary, score breakdown and related studies → Original source
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1993-08-01
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
65/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Apolipoprotein E, type epsilon 4 allele (APOE epsilon 4), is associated with late-onset familial Alzheimer's disease (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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1993-08-01
Recruitment of black elderly for clinical research studies of dementia: the CERAD experience
41/100 ✓ Peer-reviewed Disparities The Gerontologist
Key finding: Nine Consortium to Establish a Registry for Alzheimer's Disease (CERAD) sites were surveyed to identify barriers to recruiting black subjects. +3 more findings
Full summary, score breakdown and related studies → Original source
July 1993 8
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1993-07-01
Free radicals in brain metabolism and pathology
36/100 ✓ Peer-reviewed Prevention and risk British medical bulletin
Key finding: Reactive oxygen metabolites (ROM), namely superoxide and hydroxyl free radicals and hydrogen peroxide, are produced as a consequence of the physiological metabolic reactions and functioning of the central nervous system. +3 more findings
Full summary, score breakdown and related studies → Original source
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1993-07-01
Prognosis of delirium in elderly hospital patients
76/100 ✓ Peer-reviewed Clinical safety CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Key finding: Delirium in the elderly appears to have a poor prognosis. +2 more findings
Full summary, score breakdown and related studies → Original source
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1993-07-01
Driving performance in persons with mild senile dementia of the Alzheimer type
52/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society
Key finding: Some SDAT subjects retain "safe" driving skills. +1 more finding
Full summary, score breakdown and related studies → Original source
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1993-07-01
Increased Use of an Expensive, Elective Procedure: Total Hip Replacements in the 1980s
35/100 ✓ Peer-reviewed Health systems and care delivery Medical Care
Key finding: The results suggest that demands for expensive, elective procedures have been increasing for patients previously regarded as too old or impaired to benefit sufficiently.
Full summary, score breakdown and related studies → Original source
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1993-07-01
Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients
50/100 ✓ Peer-reviewed Brain tissue and pathology Genomics
Key finding: A tRNA(Gln) gene variant at nucleotide pair (np) 4336 that altered a moderately conserved nucleotide was present in 9/173 (5.2%) of the patients surveyed but in only 0.7% of the general Caucasian controls. +3 more findings
Full summary, score breakdown and related studies → Original source
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1993-07-01
Alpha 1-antichymotrypsin binding to Alzheimer A beta peptides is sequence specific and induces fibril disaggregation in vitro
43/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neurochemistry
Key finding: AD amyloid fibrils are composed primarily of A beta, which is a proteolytic fragment of the larger beta-amyloid precursor protein. +3 more findings
Full summary, score breakdown and related studies → Original source
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1993-07-01
Immunoglobulin G subclasses in older persons with Down syndrome
35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of the neurological sciences
Key finding: Significantly higher levels of IgG1 and IgG3 and lower levels of IgG2 and IgG4 subclasses were found in the DS group compared to the control individuals. +2 more findings
Full summary, score breakdown and related studies → Original source
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1993-07-01
Sensitivity and specificity for dementia of population-based criteria for cognitive impairment: the MoVIES project
48/100 ✓ Peer-reviewed Disparities Journal of gerontology
Key finding: Our data support the use of population-based cutpoints over standard cutoff scores, in that the global scale at the conventional cutoff was less sensitive than the battery at the same percentile, and because adequate norms do not exist for tests such as those in the battery.
Full summary, score breakdown and related studies → Original source
June 1993 3
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1993-06-01
Clinical determinants of dementia related to stroke
60/100 ✓ Peer-reviewed Vascular contributions Annals of neurology
Key finding: Dementia was significantly associated with age, education, and race. +3 more findings
Full summary, score breakdown and related studies → Original source
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1993-06-01
Down syndrome
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Pediatric clinics of North America
Key finding: With its increased risk of Alzheimer disease, Down syndrome is proving to be a useful model for studying aging.
Full summary, score breakdown and related studies → Original source
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1993-06-01
Time until institutionalization and death in patients with dementia. Role of caregiver training and risk factors
47/100 ✓ Peer-reviewed Caregiving Archives of neurology
Key finding: Both severity ("how far") and rate of deterioration ("how fast") influence time to NHA and death. +3 more findings
Full summary, score breakdown and related studies → Original source
May 1993 1
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1993-05-12
Population-Based Norms for the Mini-Mental State Examination by Age and Educational Level
56/100 ✓ Peer-reviewed Cognitive tests and assessment JAMA
Cognitive performance as measured by the MMSE varies within the population by age and education.
Full summary, score breakdown and related studies → Original source
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