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Association of vitamin E and C supplement use with cognitive function and dementia in elderly men
Masaki KH, Losonczy KG, Izmirlian G, Foley DJ, Ross GW, Petrovitch H, Havlik R, White LR.. Neurology, 2000-03-01
Topic: Risk, prevention and care in population studies
Objective To determine whether use of vitamin E and C supplements protects against subsequent development of dementia and poor cognitive functioning. Methods The Honolulu-Asia Aging Study is a longitudinal study of Japanese-American men living in Hawaii. Data for this study were obtained from a subsample of the cohort interviewed in 1982, and from the entire cohort from a mailed questionnaire in 1988 and the dementia prevalence survey in 1991 to 1993.
Key findings
- Methods The Honolulu-Asia Aging Study is a longitudinal study of Japanese-American men living in Hawaii.
- Data for this study were obtained from a subsample of the cohort interviewed in 1982, and from the entire cohort from a mailed questionnaire in 1988 and the dementia prevalence survey in 1991 to 1993.
- The subjects included 3,385 men, age 71 to 93 years, whose use of vitamin E and C supplements had been ascertained previously.
- Cognitive performance was assessed with the Cognitive Abilities Screening Instrument, and subjects were stratified into four groups: low, low normal, mid normal, and high normal.
Why it matters
This longitudinal study of 3,385 older Japanese-American men examined whether use of vitamin E and C supplements protects against later dementia and poor cognitive functioning. It tests a possible preventive association rather than a treatment or cure.
Study details
- Study designlongitudinal study
- Participants47
- Evidence strengthModerate
How this study scored 66/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2000 — older than 20 years, still counted |
| Sample size | 1 / 4 | 47 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 331 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.8 citations a year over 28 year(s) since 2000 |
| Impact for its field and year | 4 / 6 | Cited 10.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 16 other studies in this library |
| Still being cited | 2 / 4 | Cited 18 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Lon R. White: h-index 94 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | National Institutes of Health: institution h-index 2,723 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 10746596) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 66 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Masaki, K. H., Losonczy, K. G., Izmirlian, G., Foley, D. J., Ross, G. W., Petrovitch, H., et al. (2000). Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology. https://doi.org/10.1212/wnl.54.6.1265
Vancouver
Masaki KH, Losonczy KG, Izmirlian G, Foley DJ, Ross GW, Petrovitch H, et al. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology. 2000. doi:10.1212/wnl.54.6.1265. PMID: 10746596.
BibTeX
@article{masaki2000-10746596,
author = {Masaki, K. H. and Losonczy, K. G. and Izmirlian, G. and Foley, D. J. and Ross, G. W. and Petrovitch, H. and Havlik, R. and White, L. R.},
title = {{Association of vitamin E and C supplement use with cognitive function and dementia in elderly men}},
journal = {Neurology},
year = {2000},
doi = {10.1212/wnl.54.6.1265},
pmid = {10746596},
url = {https://doi.org/10.1212/wnl.54.6.1265}
}
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