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The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement
Sabo SL, Ikin AF, Buxbaum JD, Greengard P.. The Journal of cell biology, 2001-06-01
Topic: Amyloid, tau and blood-test diagnosis
FE65 binds to the Alzheimer amyloid precursor protein (APP), but the function of this interaction has not been identified. Here, we report that APP and FE65 are involved in regulation of cell movement. APP and FE65 colocalize with actin and Mena, an Abl-associated signaling protein thought to regulate actin dynamics, in lamellipodia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Sabo, S. L., Ikin, A. F., Buxbaum, J. D., & Greengard, P. (2001). The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. The Journal of cell biology. https://doi.org/10.1083/jcb.153.7.1403
Vancouver
Sabo SL, Ikin AF, Buxbaum JD, Greengard P. The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. The Journal of cell biology. 2001. doi:10.1083/jcb.153.7.1403. PMID: 11425871.
BibTeX
@article{sabo2001-11425871,
author = {Sabo, S. L. and Ikin, A. F. and Buxbaum, J. D. and Greengard, P.},
title = {{The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement}},
journal = {The Journal of cell biology},
year = {2001},
doi = {10.1083/jcb.153.7.1403},
pmid = {11425871},
url = {https://doi.org/10.1083/jcb.153.7.1403}
}
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Key findings
- Here, we report that APP and FE65 are involved in regulation of cell movement.
- APP and FE65 colocalize with actin and Mena, an Abl-associated signaling protein thought to regulate actin dynamics, in lamellipodia.
- APP and FE65 specifically concentrate with beta 1-integrin in dynamic adhesion sites known as focal complexes, but not in more static adhesion sites known as focal adhesions.
- Overexpression of APP accelerates cell migration in an MDCK cell wound--healing assay.
Why it matters
This laboratory study found that APP and FE65 proteins help regulate cell movement and that overexpressing APP speeds up cell migration in a wound-healing assay. It does not test any treatment, cure, or prevention of Alzheimer's disease in people.
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Study details
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journal of cell biology) |
| Journal's citation record | 4 / 4 | The Journal of Cell Biology: journal h-index 597 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2001 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 236 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.7 citations a year over 27 year(s) since 2001 |
| Impact for its field and year | 4 / 6 | Cited 10.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Paul Greengard: h-index 206 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Icahn School of Medicine at Mount Sinai: institution h-index 1,331 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 11425871) |
| Free to read | 2 / 2 | Free to read |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Also tagged “precursor”
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