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Impaired cognitive function and compliance with antihypertensive drugs in elderly: the Rotterdam Study
Salas M, In't Veld BA, van der Linden PD, Hofman A, Breteler M, Stricker BH.. Clinical pharmacology and therapeutics, 2001-12-01
Topic: Risk, prevention and care in population studies
Background To our knowledge, there are no epidemiologic studies on the association between cognitive impairment and noncompliance with antihypertensive therapy. We studied compliance with antihypertensive treatment in elderly patients with cognitive impairment. Methods The Rotterdam Study is a prospective community-based cohort study of 7983 residents > or = 55 years old.
Key findings
- We studied compliance with antihypertensive treatment in elderly patients with cognitive impairment.
- Methods The Rotterdam Study is a prospective community-based cohort study of 7983 residents > or = 55 years old.
- We studied 1979 participants in the study who had 2 consecutive Mini Mental State Examination (MMSE) assessments in the period from 1991 to 1996, who did not have dementia at baseline, and who had received 3 or more consecutive antihypertensive prescriptions for at least 6 months.
- We compared persons with MMSE scores 25 on both occasions.
Why it matters
This study examined whether cognitive impairment in elderly people was associated with not taking antihypertensive drugs as prescribed. It does not show that improving cognitive function improves medication compliance or that treating blood pressure prevents dementia, and it is an observational cohort study.
Study details
- Study designcohort study
- Participants1,979
- Effect sizeor = 0.80
- Evidence strengthModerate
How this study scored 56/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 54 of the 96 points we could judge it on, which is 56 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Clinical pharmacology and therapeutics) |
| Journal's citation record | 3 / 4 | Clinical Pharmacology & Therapeutics: journal h-index 271 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2001 — older than 20 years, still counted |
| Sample size | 3 / 4 | 1,979 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 118 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.4 citations a year over 27 year(s) since 2001 |
| Impact for its field and year | 3 / 6 | Cited 4.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 11753273) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 54 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 54 of the 96 points we could judge it on is 56 out of 100. |
| Total | 56 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Salas, M., In't Veld, B. A., van der Linden, P. D., Hofman, A., Breteler, M., & Stricker, B. H. (2001). Impaired cognitive function and compliance with antihypertensive drugs in elderly: the Rotterdam Study. Clinical pharmacology and therapeutics. https://doi.org/10.1067/mcp.2001.119812
Vancouver
Salas M, In't Veld BA, van der Linden PD, Hofman A, Breteler M, Stricker BH. Impaired cognitive function and compliance with antihypertensive drugs in elderly: the Rotterdam Study. Clinical pharmacology and therapeutics. 2001. doi:10.1067/mcp.2001.119812. PMID: 11753273.
BibTeX
@article{salas2001-11753273,
author = {Salas, M. and In't Veld, B. A. and van der Linden, P. D. and Hofman, A. and Breteler, M. and Stricker, B. H.},
title = {{Impaired cognitive function and compliance with antihypertensive drugs in elderly: the Rotterdam Study}},
journal = {Clinical pharmacology and therapeutics},
year = {2001},
doi = {10.1067/mcp.2001.119812},
pmid = {11753273},
url = {https://doi.org/10.1067/mcp.2001.119812}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.