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controlled
1,138 studies tagged controlled, dated 1986-09-01 to 2026-09-23. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Alcohol use disorder accelerates age-related cognitive decline 2026-09-23
- A longitudinal study of age-related traits and cognitive function: The Collaborative Amish Aging and Memory Project (CAAMP) 2026-09-20
- Associations of menopause hormone therapy with late-life cognition and brain health vary by formulation and APOEε4 presence 2026-09-20
Studies
1,138 studies carry this tag.
Date range
1986 to 2026
Top journals
- Alzheimer s & Dementia 42
- Neurology 41
- Journal of the American Geriatrics Society 36
- Journal of Alzheimer's disease : JAD 33
- Nutrients 23
437 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Cognitive decline occurred in 38.1% of participants but was not associated with MD adherence.
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The project is expected to generate evidence on the effectiveness, feasibility, and cost-effectiveness of multidomain interventions implemented across diverse real-world settings, including community, hospital, and long-term care.
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Sarcopenia and its components were associated with baseline MMSE and MMSE changes.
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Alzheimer's disease is a progressive neurodegenerative disorder with no cure, making preventive strategies crucial.
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Physical and cognitive decline significantly affects seniors’ quality of life.
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This study aimed to evaluate the impact of a year-long, home-based individual cognitive stimulation (iCS) program on cognitive performance, mood, functional independence, and quality of life (QoL) in older adults with mild Alzheimer’s disease and vascular dementia.
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Among 19 included studies, most used quantitative designs and secondary data.
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Out of 180 subjects, 74 showed short-term training gain transfer that was maintained over 3 months in 19 subjects.
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This randomized trial followed 2,111 older adults at risk for cognitive decline across 5 US sites for two years, comparing a highly structured lifestyle program (regular exercise, MIND diet, cognitive/social engagement, health coaching) against a lower-intensity, self-guided version of the same components.
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44/100
ApoE4 did not moderate the EF and falls relationship (p ≥ 0.05).
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Growing dementia prevalence underscores the need for efficient screening methods, but lengthy digital assessments often cause fatigue among older adults.
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[95% CI] = 0.148 [0.077-0.219]; executive function, 0.138 [0.067-0.208]; episodic memory, 0.020 [-0.051 to 0.091]; working memory, 0.128 [0.059-0.197]; visuospatial processing, 0.094 [0.023-0.164]) outperformed area-level SES in detecting cognitive deficits, and demonstrated widespread associations with poorer performance across cognitive domains.
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The global metabolic disorder, type 2 diabetes mellitus (T2DM), significantly increases the risk of cognitive dysfunction, including Alzheimer's disease (AD) and mild cognitive impairment (MCI).
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This diverse sample of Indigenous (1.65%), Black (11.43%), Hispanic (9.85%), and White (77.07%) older adults had a mean age of 61 (SD = 9.66) and was 52% female.
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42/100
This study included 5899 older adults (65+) of whom 687 reported dysphagia (median age, 80 years; 62.2% female).
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Among 809 participants (mean [SD] age at death, 91.3 [6.1] years; 538 [72%] female; mean [SD] follow-up, 7.2 [4.4] years), HS was present in 82 (10.1%) participants; 71 participants (9%) had both HS and LATE-NC, and in the scored subset, 43 participants (14%) had moderate and 35 participants (12%) had severe hippocampal neuronal loss.
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Across all participants, momentary effects of environmental distractions were minimal.
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Mild cognitive impairment progresses slowly and may be reversible, providing a window of opportunity for intervention before it progresses to Alzheimer's disease, at which point treatments, at best, ameliorate symptoms with little efficacy towards delaying disease progression.
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This study examined the combined effects of StrongerMemory program (brain exercises involving reading, writing, and math) and weekly social engagement on cognitive, behavioral, and emotional outcomes in older adults with subjective cognitive decline (SCD).
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The rural setting presented unique challenges including: low literacy rates (60.1% of participants had no schooling), diverse language use (primarily Giriama and Swahili), limited infrastructure (e.g., 44.8% of households had electricity), restrictive cultural norms that influenced data collection (e.g., in-home interviews were often conducted outdoors with destructions).
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Dementia and depression are two prevalent disorders that warrant significant attention due to their high prevalence and substantial contribution to the global burden of disease.
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Among older adults at risk of cognitive decline and dementia, a structured, higher-intensity intervention had a statistically significant greater benefit on global cognition compared with an unstructured, self-guided intervention.
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A decreasing linear trend was observed between higher levels of curry consumption and cognitive decline (p = 0.037).
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This work was supported by a Crossover grant (Maintaining Optimal Cognitive Functioning In Aging [MOCIA] 17611) of the Dutch Research Council (NWO), granted in December 2019.
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Mild cognitive impairment (MCI) is the transitional stage between normal cognition and dementia and is associated with arterial stiffness, which may lead to cardiovascular disease.
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This study aims to identify depressive risks in elderly individuals with subjective cognitive decline (SCD) and develop a predictive model using machine learning algorithms to enable timely interventions.
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Cognitive decline and dementia represent escalating global health challenges with limited therapeutic options, highlighting the need for effective preventive strategies.
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Dementia syndromes involve cognitive but also early motor impairment.
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As states work to maximize limited resources while improving population outcomes, the strategic alignment of planning processes represents a significant opportunity.
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The primary analysis demonstrated significant improvements in multiple episodic memory measures across both intervention groups, with no significant differences observed between groups.
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After the intervention, the CG showed significantly lower scores compared to all experimental groups.
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Among 90 participants included in the analyses, 34 had moderate to severe WMH.
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There were no significant associations in men.
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Our results will provide new evidence of the efficacy of an innovative multi-component intervention integrating IVR and telemedicine in SCD individuals.
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The StrongerMemory program, a structured intervention involving reading aloud, writing by hand, and completing simple math problems, is designed to stimulate the prefrontal cortex and enhance cognitive functioning.
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Cognitive decline in older adults has significant implications for autonomy and quality of life.
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Black Americans a have higher risk of cognitive impairment relative to other racial/ethnic groups, and Black women have the highest prevalence of Alzheimer's disease and related dementias; however, the mechanisms underlying cognitive impairment are poorly understood.
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The study determined an adequate sample size (KMO = 0.67), with sufficient item correlations for factor analysis (χ2 = 449.74; p < 0.001).
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Cognitive training, whether combined with active or sham tDCS, led to significantly increased fractional anisotropy averaged across all brain regions, indicating an overall improvement in white matter integrity.
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42/100
Gender has an impact on CR, but not through socio‐economic variables.
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Consistent with previous research, transfer gains from the OMT condition to an untrained VM task suggest that olfaction may contribute to a‐modal representations of memory.
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The CITA GO-ON Study, as a part of the World-Wide FINGERS network, is designed to validate the efficacy of a multidomain lifestyle intervention for dementia prevention and contribute valuable data to inform public health strategies fostering healthy, active aging.
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Data collection commenced in November 2023 and finished in July 2024, with the enrollment of 49 older adults with MCI (n=40, 81.6%, assigned to the experimental group [EG] and n=9, 18.4%, to the control group [CG]) conducted from October 2023 to April 2024.
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Linear and logistic regression showed that childhood rural residence was associated with lower memory (standardized beta (β) = -1.68, 95% Confidence Interval (CI) [-2.39, -0.97]), executive function (β = -1.20, 95% CI [-1.84, -0.55]), and language fluency (β = -0.86, 95% CI [-1.64, -0.08]).
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35/100
Age-related cognitive decline, characterized by memory loss, attention deficits, and reduced executive function, remains a major public health challenge, with limited pharmaceutical interventions offering symptomatic relief.
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59/100
Aging is associated with physiological changes that increase the risk of falls, impacting functional independence and quality of life.
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The MI group significantly improved in attention-executive functioning (p = 0.003) compared to ACI (Cohen's d: 0.47, 95% CI 0.13-0.79).
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The trial occurred during the COVID-19 pandemic.
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The relation between vitamin A (VA) level and cognitive function and the underlying mechanisms have not been thoroughly investigated.
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Metabolic syndrome (MetS) is characterized by central obesity, insulin resistance, hypertension, dyslipidemia, and chronic inflammation, significantly increasing the risk of cardiovascular disease and type 2 diabetes.
From across this tag
10 of the 1,130 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Sleep Duration and White Matter Quality in Middle-Aged Adults
- Cognitive Flexibility Training: A Large-Scale Multimodal Adaptive Active-Control Intervention Study in Healthy Older Adults
- Mediterranean diet, healthy eating index 2005, and cognitive function in middle-aged and older Puerto Rican adults
- The Effects of Cognitive Training for Elderly: Results from My Mind Project
- The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years
- Brain plasticity and motor practice in cognitive aging
- What is the effectiveness of cognitive training in preventing cognitive decline in individuals at risk for Alzheimer's disease?
- Adoption of Medicare's Cognitive Assessment and Care Plan Services Benefit: People, Plans, Payment, and Providers
- Social interaction as a unique form of reward – Insights from healthy ageing and frontotemporal dementia
- The impact of inflammation on cognitive function in older adults: implications for healthcare practice and research