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Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program
Chukwuma Okoye, Luca Cuffaro, Federico Emanuele Pozzi, Maria Cristina Ferrara, Marianna Noale, Stefano Calciolari, Davide Chicco, Febo Cincotti et al.. The Journals of Gerontology Series B, 2025-09-28
Topic: Risk, prevention and care in population studies
The project is expected to generate evidence on the effectiveness, feasibility, and cost-effectiveness of multidomain interventions implemented across diverse real-world settings, including community, hospital, and long-term care. Technology-assisted strategies-such as wearable sensors and digital cognitive tools-may enhance adherence and enable remote monitoring, while also supporting more personalized care delivery. The integration of artificial intelligence will facilitate the interpretation of complex clinical and biological data, improving risk stratification and the early identification of individuals most likely to benefit from targeted interventions. Together, these approaches may help reduce hospitalizations, delay functional decline, and promote aging in place. This initiative supports the transition toward more integrated and equitable care models for older adults. Through the implementation of scalable, person-centered interventions within routine services, the project offers policy-relevant strategies to address frailty and functional decline-contributing to the redesign of aging care in Italy and providing insights applicable across diverse health systems facing the challenges of population aging countries.
Key findings
- The project is expected to generate evidence on the effectiveness, feasibility, and cost-effectiveness of multidomain interventions implemented across diverse real-world settings, including community, hospital, and long-term care.
- Technology-assisted strategies-such as wearable sensors and digital cognitive tools-may enhance adherence and enable remote monitoring, while also supporting more personalized care delivery.
- The integration of artificial intelligence will facilitate the interpretation of complex clinical and biological data, improving risk stratification and the early identification of individuals most likely to benefit from targeted interventions.
- Together, these approaches may help reduce hospitalizations, delay functional decline, and promote aging in place.
- This initiative supports the transition toward more integrated and equitable care models for older adults.
Why it matters
This describes a research program expected to generate evidence on multidomain interventions and technology-assisted strategies for frailty and cognitive decline. It reports no results yet and cannot show whether any approach prevents or treats Alzheimer's disease.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journals of Gerontology Series B) |
| Journal's citation record | 2 / 4 | The Journals of Gerontology Series B: journal h-index 225 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 5 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author C Zoia: h-index 24 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Toronto: institution h-index 1,923 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 10 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41442763) |
| Free to read | 2 / 2 | Free to read |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1093/geronb/gbaf186
- PubMed: 41442763
- Original source →
- Free full text: The Journals of Gerontology Series B →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Okoye, C., Cuffaro, L., Pozzi, F. E., Ferrara, M. C., Noale, M., Calciolari, S., et al. (2025). Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program. The Journals of Gerontology Series B. https://doi.org/10.1093/geronb/gbaf186
Vancouver
Okoye C, Cuffaro L, Pozzi FE, Ferrara MC, Noale M, Calciolari S, et al. Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program. The Journals of Gerontology Series B. 2025. doi:10.1093/geronb/gbaf186. PMID: 41442763.
BibTeX
@article{okoye2025-41442763,
author = {Okoye, Chukwuma and Cuffaro, Luca and Pozzi, Federico Emanuele and Ferrara, Maria Cristina and Noale, Marianna and Calciolari, Stefano and Chicco, Davide and Cincotti, Febo and others},
title = {{Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program}},
journal = {The Journals of Gerontology Series B},
year = {2025},
doi = {10.1093/geronb/gbaf186},
pmid = {41442763},
url = {https://doi.org/10.1093/geronb/gbaf186}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
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