This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

63/100

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Prevention trials

Topic: Amyloid, tau and blood-test diagnosis

Alzheimer's disease is a progressive neurodegenerative disorder with no cure, making preventive strategies crucial. Dietary interventions, particularly the Mediterranean (MeDi) and MIND diets, have been associated with reduced cognitive decline, but their long-term comparative effects remain underexplored. To compare the long-term neuroprotective effects of the Mediterranean and MIND diets in healthy individuals and AD patients, assess dietary adherence and cognitive function relationships, and investigate the impact of micronutrients on cognitive biomarkers. A 5-year prospective cohort study was conducted with 1500 participants (750 healthy controls, 750 AD patients). Dietary adherence was assessed using validated dietary screening tools. Cognitive function was evaluated via MMSE and MoCA scores, while biomarkers (amyloid-beta, tau, NfL, CRP, IL-6, TNF-α, polyphenols, omega-3, and B vitamins) were measured through blood and CSF samples. Machine learning techniques were utilized to analyze dietary patterns and predict cognitive trajectories. Higher adherence to both diets was associated with significantly better cognitive scores (p < 0.0001), lower amyloid-beta, tau, and NfL levels, and reduced inflammatory markers (CRP, IL-6, TNF-α). The MIND diet showed a slightly stronger association with cognitive protection than MeDi. Micronutrients such as polyphenols, omega-3, and B vitamins correlated with improved cognitive performance. Genetic analysis suggested that APOE-ε4 carriers may experience variable responses to dietary interventions. The Mediterranean and MIND diets provide significant neuroprotection against cognitive decline and AD progression. While both diets confer benefits, the MIND diet demonstrated a marginally greater impact on cognitive preservation. These findings underscore the importance of dietary interventions as non-pharmacological strategies for AD prevention and management. Further research is needed to optimize dietary recommendations based on genetic predisposition and metabolic factors.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Liu, X., Yang, B., Liu, Q., Gao, M., & Luo, M. (2025). The long-term neuroprotective effect of MIND and Mediterranean diet on patients with Alzheimer’s disease. Scientific Reports. https://doi.org/10.1038/s41598-025-17055-5

Vancouver

Liu X, Yang B, Liu Q, Gao M, Luo M. The long-term neuroprotective effect of MIND and Mediterranean diet on patients with Alzheimer’s disease. Scientific Reports. 2025. doi:10.1038/s41598-025-17055-5. PMID: 40993193.

BibTeX

@article{liu2025-40993193,
  author  = {Liu, Xiaofang and Yang, Bo and Liu, Qiong and Gao, Mengge and Luo, Miaoqing},
  title   = {{The long-term neuroprotective effect of MIND and Mediterranean diet on patients with Alzheimer’s disease}},
  journal = {Scientific Reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-17055-5},
  pmid    = {40993193},
  url     = {https://doi.org/10.1038/s41598-025-17055-5}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

Key findings

Dietary interventions, particularly the Mediterranean (MeDi) and MIND diets, have been associated with reduced cognitive decline, but their long-term comparative effects remain underexplored.
Higher adherence to both diets was associated with significantly better cognitive scores (p < 0.0001), lower amyloid-beta, tau, and NfL levels, and reduced inflammatory markers (CRP, IL-6, TNF-α).
Genetic analysis suggested that APOE-ε4 carriers may experience variable responses to dietary interventions.
The Mediterranean and MIND diets provide significant neuroprotection against cognitive decline and AD progression.
While both diets confer benefits, the MIND diet demonstrated a marginally greater impact on cognitive preservation.

Why it matters

In this five-year study of 1500 people, higher adherence to the Mediterranean or MIND diet was associated with better cognitive scores and lower amyloid-beta, tau, and inflammatory markers, with the MIND diet showing a slightly stronger link. It is an observational cohort study, so it cannot prove that diet prevents or treats Alzheimer's, and APOE-ε4 carriers may respond differently.

New to this subject? Start with our plain-English guide: Prevention →

Study details

Study designcohort study
Participants1,500
Evidence strengthModerate

How this study scored 63/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record and institution's track record, so those were left out: it earned 59 of the 93 points we could judge it on, which is 63 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Scientific Reports)
Journal's citation record	3 / 4	Scientific Reports: journal h-index 463 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	3 / 4	1,500 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	3 / 7	Cited 24 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	8.0 citations a year over 3 year(s) since 2025
Impact for its field and year	5 / 6	Cited 20.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	2 / 4	Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multi-centre collaboration	0 / 3	OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40993193)
Free to read	2 / 2	Free to read
Points	59 / 93	Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 59 of the 93 points we could judge it on is 63 out of 100.
Total	63 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies in the library that share something with this one. The line above each title says what.

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here.

Later studies that cite this one

4 studies in the alzhub library list this one in their references.

Related studies in Prevention trials

Also tagged “controlled”

1,116 studies in the library carry the topic tag “controlled”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,116 tagged studies.

Studies sharing this one's topic tags

Similar studies

More on Prevention trials

See all studies in Prevention trials →