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You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. The prevalence of peripheral and central hearing impairment and its relation to cognition in older adults

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Audiology & neuro-otology 2014-01-01 Risk factors

    Age-related hearing loss (ARHL) and dementia are two highly prevalent conditions in the adult population.

  2. Are Empirically-Derived Subtypes of Mild Cognitive Impairment Consistent with Conventional Subtypes?

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of the International Neuropsychological Society 2013-04-03 Prevention trials

    Given the importance of identifying dementia prodromes for future treatment efforts, we examined two methods of diagnosing mild cognitive impairment (MCI) and determined whether empirically-derived MCI subtypes of these diagnostic methods were consistent with one another as well as with conventional MCI subtypes (i.e., amnestic, non-amnestic, single-domain, multi-domain).

  3. Resting-state fMRI as a biomarker for Alzheimer's disease?

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Alzheimer's research & therapy 2012-03-15 Brain scans and imaging

    Previous work indicates that resting-state functional magnetic resonance imaging (fMRI) is sensitive to functional brain changes related to Alzheimer's disease (AD) pathology across the clinical spectrum.

  4. Cognitive activity, education and socioeconomic status as preventive factors for mild cognitive impairment and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Psychiatry research 2012-03-04 Disparities

    Growing epidemiological evidence suggests that premorbid participation in cognitive leisure activities (CLA) reduces the risk of dementia by increasing cognitive reserve.

  5. Early diagnosis of Alzheimer's disease using cortical thickness: impact of cognitive reserve

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain : a journal of neurology 2009-05-12 Getting a diagnosis

    Normalized thickness index at baseline differed significantly among all the four diagnosis groups (P < 0.001) and correctly distinguished Alzheimer's disease patients from healthy controls with an 85% cross-validated accuracy.

  6. Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain : a journal of neurology 2008-10-16 Biomarkers

    WMH are only weakly and inconsistently associated with cognitive decline, which may be explained by heterogeneity of the underlying neuropathological substrates.

  7. Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Archives of general psychiatry 2006-08-01 Mild cognitive impairment

    Mild cognitively impaired patients with memory plus other cognitive domain deficits, rather than those with pure amnestic MCI, constituted the high-risk group.

  8. A prospective longitudinal study of apathy in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of Neurology Neurosurgery & Psychiatry 2005-12-16 Clinical safety

    Apathy was significantly associated with older age (p = 0.009), and a higher frequency of minor and major depression (p < 0.0001).

  9. The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. BMC Neurology 2005-12-01 Brain scans and imaging

    Age and BMI were each associated with decreased brain volume.

  10. Neuroanatomical correlates of behavioural disorders in dementia

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain : a journal of neurology 2005-09-29 Clinical safety

    Neurodegenerative diseases are associated with profound changes in social and emotional function.

  11. Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. American journal of epidemiology 2004-01-01 Disparities

    In this study, the authors evaluated whether the association between low educational level and increased risk of Alzheimer's disease (AD) and dementia may be explained by occupation-based socioeconomic status (SES).

  12. A Collaborative Study of the Emergence and Clinical Features of the Major Depressive Syndrome of Alzheimer’s Disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. American Journal of Psychiatry 2003-05-01 Risk factors

    Despite the use of a common, reliable methodology for the assessment and diagnosis of major depressive episodes, the prevalence of major depression in Alzheimer's disease ranged widely from 22.5% to 54.4% across the recruitment sites.

  13. High occurrence rate of glaucoma among patients with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. European neurology 2002-01-01 Brain scans and imaging

    The purpose of the current study was to reveal the occurrence rate of glaucoma among patients with Alzheimer's disease (AD).

  14. Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Lancet (London, England) 2001-07-01 Getting a diagnosis

    Progressive atrophy was revealed in presymptomatic individuals, with posterior cingulate and neocortical temporoparietal cortical losses, and medial temporal-lobe atrophy.

  15. Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Neurology 1996-03-01 Brain scans and imaging

    Hippocampal atrophy detected by volumetric MRI is a sensitive feature of early Alzheimer's disease (AD), but there are no studies evaluating hippocampal atrophy by MR volumetry in other dementing diseases.

  16. The consortium to establish a registry for Alzheimer's disease (CERAD). Part IV. Rates of cognitive change in the longitudinal assessment of probable Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Neurology 1993-12-01 Health systems and care delivery

    Reliable information on rate of progression of cognitive impairment in probable Alzheimer's disease (AD) is important for evaluating possible beneficial effects of therapeutic agents and in planning long-term care for patients with this chronic illness.

  17. The functional role of the precuneus

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain 2023-05-31 Brain scans and imaging

    Recent advancements in computational approaches and neuroimaging techniques have refined our understanding of the precuneus.

  18. Multimodal deep learning for Alzheimer's disease dementia assessment

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature communications 2022-06-20 Digital health tools

    Worldwide, there are nearly 10 million new cases of dementia annually, of which Alzheimer's disease (AD) is the most common.

  19. Current advances in digital cognitive assessment for preclinical Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2021-07-20 Cognitive tests and assessment

    There is a pressing need to capture and track subtle cognitive change at the preclinical stage of Alzheimer's disease (AD) rapidly, cost-effectively, and with high sensitivity.

  20. Transformer-based deep neural network language models for Alzheimer's disease risk assessment from targeted speech

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. BMC medical informatics and decision making 2021-03-09 Digital health tools

    Using pre-trained language models can improve AD prediction.

  21. Hearing and dementia: from ears to brain

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain : a journal of neurology 2021-03-01 Risk factors

    The association between hearing impairment and dementia has emerged as a major public health challenge, with significant opportunities for earlier diagnosis, treatment and prevention.

  22. Functional ability is associated with higher adherence to behavioral interventions in mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Clinical neuropsychologist 2019-10-13 Cognitive tests and assessment

    Two-hundred and thirty-seven participants completed the 6-month post-intervention follow-up measures, 228 participants completed the 12-month measures, and 218 participants completed the 18-month measures.

  23. β-Amyloid accumulation in the human brain after one night of sleep deprivation

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2018-04-09 Genetics

    The effects of acute sleep deprivation on β-amyloid (Aβ) clearance in the human brain have not been documented.

  24. Music, memory and mechanisms in Alzheimer’s disease: Figure 1

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain 2015-07-23 Treatments

    These same brain areas were then assessed in a cohort of patients with Alzheimer’s disease versus a healthy older reference group, using a region of interest approach combined with standard structural (MRI), metabolic (fluorodeoxyglucose-PET) and amyloid ligand (florbetapir-PET) neuroimaging.

  25. Usability and Validity of a Battery of Computerised Cognitive Screening Tests for Detecting Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Gerontology 2015-06-24 Cognitive tests and assessment

    The participants had little difficulty self-administering the CCS, which is an oft-cited barrier to computerised testing in this population.

From across this topic

10 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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