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Are Empirically-Derived Subtypes of Mild Cognitive Impairment Consistent with Conventional Subtypes?
Lindsay R. Clark, Lisa Delano‐Wood, David J. Libon, Carrie R. McDonald, Daniel A. Nation, Katherine J. Bangen, Amy J. Jak, Rhoda Au et al.. Journal of the International Neuropsychological Society, 2013-04-03
Topic: Brain imaging, connectivity and assessment
Given the importance of identifying dementia prodromes for future treatment efforts, we examined two methods of diagnosing mild cognitive impairment (MCI) and determined whether empirically-derived MCI subtypes of these diagnostic methods were consistent with one another as well as with conventional MCI subtypes (i.e., amnestic, non-amnestic, single-domain, multi-domain). Participants were diagnosed with MCI using either conventional Petersen/Winblad criteria (n = 134; >1.5 SDs below normal on one test within a cognitive domain) or comprehensive neuropsychological criteria developed by Jak et al. (2009) (n = 80; >1 SD below normal on two tests within a domain), and the resulting samples were examined via hierarchical cluster and discriminant function analyses. Results showed that neuropsychological profiles varied depending on the criteria used to define MCI. Both criteria revealed an Amnestic subtype, consistent with prodromal Alzheimer's disease (AD), and a Mixed subtype that may capture individuals in advanced stages of MCI. The comprehensive criteria uniquely yielded Dysexecutive and Visuospatial subtypes, whereas the conventional criteria produced a subtype that performed within normal limits, suggesting its susceptibility to false positive diagnostic errors. Whether these empirically-derived MCI subtypes correspond to dissociable neuropathologic substrates and represent reliable prodromes of dementia will require additional follow-up.
Key findings
- Results showed that neuropsychological profiles varied depending on the criteria used to define MCI.
- Both criteria revealed an Amnestic subtype, consistent with prodromal Alzheimer's disease (AD), and a Mixed subtype that may capture individuals in advanced stages of MCI.
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Study details
- Participants134
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 28 of the 58 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the International Neuropsychological Society) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 134 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23552486) |
| Free to read | 2 / 2 | Free to read |
| Points | 28 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 28 of the 58 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
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APA 7th
Clark, L. R., Delano‐Wood, L., Libon, D. J., McDonald, C. R., Nation, D. A., Bangen, K. J., et al. (2013). Are Empirically-Derived Subtypes of Mild Cognitive Impairment Consistent with Conventional Subtypes? Journal of the International Neuropsychological Society. https://doi.org/10.1017/s1355617713000313
Vancouver
Clark LR, Delano‐Wood L, Libon DJ, McDonald CR, Nation DA, Bangen KJ, et al. Are Empirically-Derived Subtypes of Mild Cognitive Impairment Consistent with Conventional Subtypes? Journal of the International Neuropsychological Society. 2013. doi:10.1017/s1355617713000313. PMID: 23552486.
BibTeX
@article{clark2013-23552486,
author = {Clark, Lindsay R. and Delano‐Wood, Lisa and Libon, David J. and McDonald, Carrie R. and Nation, Daniel A. and Bangen, Katherine J. and Jak, Amy J. and Au, Rhoda and others},
title = {{Are Empirically-Derived Subtypes of Mild Cognitive Impairment Consistent with Conventional Subtypes?}},
journal = {Journal of the International Neuropsychological Society},
year = {2013},
doi = {10.1017/s1355617713000313},
pmid = {23552486},
url = {https://doi.org/10.1017/s1355617713000313}
}
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