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Associations Between Sleep‐Disordered Breathing, Nocturnal Hypoxemia, and Subsequent Cognitive Decline in Older Community‐Dwelling Men: The Osteoporotic Fractures in Men Sleep Study
Terri Blackwell, Kristine Yaffe, Alison Laffan, Susan Redline, Sonia Ancoli‐Israel, Kristine E. Ensrud, Yeonsu Song, Katie L. Stone et al.. Journal of the American Geriatrics Society, 2015-03
Topic: Brain imaging, connectivity and assessment
Nocturnal hypoxemia was related to greater decline on the 3 MS . Men with 1% or more of sleep time with SaO 2 less than 90% had an adjusted annualized decline of 0.43 points, compared with 0.25 for men in the reference group ( P = .003). For each 5‐point increase in ODI , there was an average annualized decline of 0.36 points ( P = .01). Results were robust to further adjustment for potential mediators. The association between AHI and cognitive decline did not reach significance. No associations were seen with SDB and decline on the Trails B. In older community‐dwelling men, there was a modest association between nocturnal hypoxemia and global cognitive decline, suggesting the importance of overnight oxygenation for cognitive function.
Key findings
- Nocturnal hypoxemia was related to greater decline on the 3 MS .
- Men with 1% or more of sleep time with SaO 2 less than 90% had an adjusted annualized decline of 0.43 points, compared with 0.25 for men in the reference group ( P = .003).
- For each 5‐point increase in ODI , there was an average annualized decline of 0.36 points ( P = .01).
- Results were robust to further adjustment for potential mediators.
- The association between AHI and cognitive decline did not reach significance.
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Study details
- Study designlongitudinal study
- Participants2,636
- Effect sizeor 3.4
- Evidence strengthModerate
How this study scored 66/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 37 of the 56 points we could judge it on, which is 66 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Geriatrics Society) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 2,636 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 37 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 37 of the 56 points we could judge it on is 66 out of 100. |
| Total | 66 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Blackwell, T., Yaffe, K., Laffan, A., Redline, S., Ancoli‐Israel, S., Ensrud, K. E., et al. (2015). Associations Between Sleep‐Disordered Breathing, Nocturnal Hypoxemia, and Subsequent Cognitive Decline in Older Community‐Dwelling Men: The Osteoporotic Fractures in Men Sleep Study. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.13321
Vancouver
Blackwell T, Yaffe K, Laffan A, Redline S, Ancoli‐Israel S, Ensrud KE, et al. Associations Between Sleep‐Disordered Breathing, Nocturnal Hypoxemia, and Subsequent Cognitive Decline in Older Community‐Dwelling Men: The Osteoporotic Fractures in Men Sleep Study. Journal of the American Geriatrics Society. 2015. doi:10.1111/jgs.13321.
BibTeX
@article{blackwell2015-5b882753,
author = {Blackwell, Terri and Yaffe, Kristine and Laffan, Alison and Redline, Susan and Ancoli‐Israel, Sonia and Ensrud, Kristine E. and Song, Yeonsu and Stone, Katie L. and others},
title = {{Associations Between Sleep‐Disordered Breathing, Nocturnal Hypoxemia, and Subsequent Cognitive Decline in Older Community‐Dwelling Men: The Osteoporotic Fractures in Men Sleep Study}},
journal = {Journal of the American Geriatrics Society},
year = {2015},
doi = {10.1111/jgs.13321},
url = {https://doi.org/10.1111/jgs.13321}
}
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