Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. JAMA neurology 2015-06-01 Digital health tools

    Under normal conditions, vivid dream mentation combined with skeletal muscle paralysis characterizes rapid eye movement sleep.

  2. Seizures and epileptiform activity in the early stages of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. JAMA neurology 2013-09-01 Risk genes beyond APOE

    Patients with aMCI who had epilepsy presented with symptoms of cognitive decline 6.8 years earlier than patients with aMCI who did not have epilepsy (64.3 vs 71.1 years; P = .02).

  3. Neuroimaging of cognitive dysfunction and depression in aging retired National Football League players: a cross-sectional study

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. JAMA neurology 2013-03-01 Biomarkers

    Cognitive deficits and depression appear to be more common in aging former NFL players compared with healthy controls.

  4. Disrupted functional brain connectome in individuals at risk for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Biological psychiatry 2012-04-25 Brain scans and imaging

    This study demonstrates a disruption of whole-brain topological organization of the functional connectome in aMCI.

  5. Associations between physical performance and executive function in older adults with mild cognitive impairment: gait speed and the timed "up & go" test

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Physical therapy 2011-05-26 Digital health tools

    Physical performance speed was associated with executive function after adjusting for age, sex, and age-related factors in sedentary older adults with aMCI.

  6. Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. BMC neuroscience 2009-08-21 Digital health tools

    With decreasing local and global connectivity parameters, the large-scale functional brain network organization in AD deviates from the optimal 'small-world' network structure towards a more 'random' type.

  7. The use of the Modified Telephone Interview for Cognitive Status (TICS-M) in the detection of amnestic mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of geriatric psychiatry and neurology 2009-06-01 Prevention trials

    Many screening tools for detecting cognitive decline require in-person assessment, which is often not cost-effective or feasible for those with physical limitations.

  8. BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurobiology of learning and memory 2008-09-06 Drug development

    Brain-derived neurotrophic factor (BDNF) is one of the key molecules modulating brain plasticity.

  9. Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain : a journal of neurology 2008-07-11 Clinical safety

    Alzheimer's disease research has largely concentrated on the study of cognitive decline, but the associated behavioural and neuropsychiatric symptoms are of equal importance in the clinical profile of the disease.

  10. Reliability and validity of a computerized neurocognitive test battery, CNS Vital Signs

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists 2006-10-02 Risk factors

    CNS Vital Signs (CNSVS) is a computerized neurocognitive test battery that was developed as a routine clinical screening instrument.

  11. The assessment of cognitive function in advanced HIV-1 infection and AIDS dementia complex using a new computerised cognitive test battery

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists 2005-12-15 Cognitive tests and assessment

    The validity of a new computerised battery called CogState was determined in 60 individuals with advanced human immunodeficiency virus-1 (HIV-1) infection from which eleven were assessed as AIDS dementia complex (ADC) stage 1 or 2.

  12. The epidemiology of the comorbidity of epilepsy in the general population

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Epilepsia 2004-12-01 Getting a diagnosis

    The prevalence ratio of many common psychiatric and somatic conditions is increased in adults with epilepsy who consult a primary care physician in the U.K. These findings may have implications in the diagnosis and management of epilepsy and coexisting conditions, as well as in health care provision.

  13. Progressive posterior cortical dysfunction

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurology 2004-10-12 Risk factors

    Neuropathologic etiologies of PPCD were Alzheimer disease (AD) (n = 13), AD plus Parkinson disease (n = 1), AD-Lewy body variant (n = 2), dementia with Lewy bodies plus progressive subcortical gliosis of Neumann (n = 1), corticobasal degeneration (n = 2), and prion-associated diseases: Creutzfeldt-Jakob disease (n = 1) and fatal familial insomnia (n = 1).

  14. What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain : a journal of neurology 2004-02-04 Digital health tools

    Confrontation naming is impaired in neurodegenerative conditions like Alzheimer's disease (AD), frontotemporal dementia (FTD) and corticobasal degeneration (CBD).

  15. Validity of a novel computerized cognitive battery for mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. BMC geriatrics 2003-11-02 Cognitive tests and assessment

    Mindstreams tests are effective in detecting MCI, providing a comprehensive profile of cognitive function.

  16. Autobiographical memory and autonoetic consciousness: triple dissociation in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain 2003-06-23 Lewy body dementia

    An alternative model, the multiple trace theory (MTT), suggests that the capacity of the MTL to recollect episodic memories is of a more permanent nature.

  17. The Effect of Education on Cognitive Performances and Its Implication for the Constitution of the Cognitive Reserve

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Developmental Neuropsychology 2003-06-01 Disparities

    Some studies have suggested that people with a high educational level have a lower risk of developing dementia compared to people with a low educational level.

  18. Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Annals of neurology 2001-04-01 Brain scans and imaging

    Volumetric magnetic resonance imaging analyses of 30 subjects were undertaken to quantify the global and temporal lobe atrophy in semantic dementia and Alzheimer's disease.

  19. Olfactory Deficits in Patients With Mild Cognitive Impairment Predict Alzheimer’s Disease at Follow-Up

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. American Journal of Psychiatry 2000-09-01 Risk factors

    Olfaction scores were lower in patients with mild cognitive impairment than in healthy comparison subjects.

  20. Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Annals of neurology 2000-01-01 Getting a diagnosis

    To evaluate the utility of arterial spin-labeled blood flow magnetic resonance imaging for the detection of cerebral blood flow abnormalities in Alzheimer's disease, arterial spin-labeled blood flow images in 16 contiguous 5-mm axial sections were acquired in 18 patients diagnosed with probable Alzheimer's disease and 11 age-matched controls.

  21. Evaluation of the NINCDS-ADRDA criteria in the differentiation of Alzheimer's disease and frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of Neurology Neurosurgery & Psychiatry 1999-02-01 Lewy body dementia

    (1) The overall sensitivity of the NINCDS-ADRDA criteria in diagnosing "probable" AD from 56 patients with cortical dementia (AD and FTD) was 0.93.

  22. REM sleep behavior disorder and degenerative dementia

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurology 1998-08-01 Risk factors

    Thirty-four of the 37 patients were male with mean age at onset of 61.5 years for RBD and 68.1 years for cognitive decline.

  23. Talking while walking: the effect of a dual task in aging and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurology 1997-04-01 Digital health tools

    We determined the effects of distraction on gait in healthy elderly subjects and Alzheimer's disease (AD) patients.

  24. The Evolution of Psychiatric Symptoms in Alzheimer's Disease: A Natural History Study

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of the American Geriatrics Society 1996-09-01 Clinical safety

    Irritability, agitation, and aggression were documented in 81 patients (81%) an average of 10 months after diagnosis.

  25. Predictors of cognitive and functional progression in patients with probable Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurology 1992-09-01 Risk factors

    We followed 65 patients with probable Alzheimer's disease, who were initially mildly to moderately impaired, with semiannual assessments of cognitive and functional performance for up to 4 years.

From across this topic

10 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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