Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Gait assessment in mild cognitive impairment and Alzheimer's disease: the effect of dual-task challenges across the cognitive spectrum

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Gait & posture 2011-09-22 Digital health tools

    Gait impairment is a prominent falls risk factor and a prevalent feature among older adults with cognitive impairment.

  2. BEaST: brain extraction based on nonlocal segmentation technique

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2011-09-16 Long-term cohort studies

    Brain extraction is an important step in the analysis of brain images.

  3. Large-scale brain networks and psychopathology: a unifying triple network model

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in cognitive sciences 2011-09-09 Risk factors

    The science of large-scale brain networks offers a powerful paradigm for investigating cognitive and affective dysfunction in psychiatric and neurological disorders.

  4. Functional connectivity tracks clinical deterioration in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2011-08-16 Brain scans and imaging

    While resting state functional connectivity has been shown to decrease in patients with mild and/or moderate Alzheimer's disease, it is not yet known how functional connectivity changes in patients as the disease progresses.

  5. Resting state fMRI in Alzheimer's disease: beyond the default mode network

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2011-08-03 Brain scans and imaging

    Using resting state (RS) functional magnetic resonance imaging (fMRI), the connectivity patterns of the default mode (DMN), frontoparietal, executive, and salience networks were explored in 13 Alzheimer's disease (AD) patients, 12 amnestic mild cognitive impairment (aMCI) patients, and 13 healthy controls.

  6. Resting-state brain networks: literature review and clinical applications

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2011-06-11 Brain scans and imaging

    This review focuses on resting-state functional connectivity, a functional MRI technique which allows the study of spontaneous brain activity generated under resting conditions.

  7. Cognitive reserve in aging

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current Alzheimer research 2011-06-01 Risk factors

    Cognitive reserve explains why those with higher IQ, education, occupational attainment, or participation in leisure activities evidence less severe clinical or cognitive changes in the presence of age-related or Alzheimer's disease pathology.

  8. Relationships between β-amyloid and functional connectivity in different components of the default mode network in aging

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cerebral cortex (New York, N.Y. : 1991) 2011-03-07 Brain scans and imaging

    Although beta-amyloid (Aβ) deposition is a characteristic feature of Alzheimer's disease (AD), this pathology is commonly found in elderly normal controls (NC).

  9. Microinfarct pathology, dementia, and cognitive systems

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Stroke 2011-01-06 Long-term cohort studies

    Microinfarcts are common, and persons with multiple cortical microinfarcts have higher odds of dementia.

  10. Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010-12-01 Brain scans and imaging

    Recent research on Alzheimer's disease (AD) has shown that the decline of cognitive and memory functions is accompanied by a disrupted neuronal connectivity characterized by white matter (WM) degeneration.

  11. How common are behavioural changes in amyotrophic lateral sclerosis?

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2010-09-19 Caregiving

    Our objectives were to assess the frequency of behavioural changes in patients with amyotrophic lateral sclerosis (ALS) and to compare the clinical profile of ALS patients with those with behavioural variant frontotemporal dementia (bvFTD).

  12. Diagnosis of Alzheimer's disease from EEG signals: where are we standing?

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current Alzheimer research 2010-09-01 Brain scans and imaging

    This paper reviews recent progress in the diagnosis of Alzheimer's disease (AD) from electroencephalograms (EEG).

  13. Graph theoretical modeling of brain connectivity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current opinion in neurology 2010-08-01 Brain scans and imaging

    In recent years, there has been an explosion of studies on network modeling of brain connectivity.

  14. Prediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2010-07-01 Tau biomarkers

    Magnetic resonance imaging (MRI) patterns were examined together with cerebrospinal fluid (CSF) biomarkers in serial scans of Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with mild cognitive impairment (MCI).

  15. Boosting power for clinical trials using classifiers based on multiple biomarkers

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2010-06-11 Digital health tools

    Machine learning methods pool diverse information to perform computer-assisted diagnosis and predict future clinical decline.

  16. Exploring the brain network: a review on resting-state fMRI functional connectivity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2010-05-14 Brain scans and imaging

    Our brain is a network. It consists of spatially distributed, but functionally linked regions that continuously share information with each other.

  17. High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2010-03-23 Mild cognitive impairment

    Functional magnetic resonance imaging (fMRI) studies have observed hyperactivity in the hippocampal region in individuals with Mild Cognitive Impairment (MCI).

  18. Functional alterations in memory networks in early Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuromolecular medicine 2010-03-01 Brain scans and imaging

    The hallmark clinical symptom of early Alzheimer's disease (AD) is episodic memory impairment.

  19. Estimating the age of healthy subjects from T1-weighted MRI scans using kernel methods: exploring the influence of various parameters

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2010-01-11 Brain scans and imaging

    The early identification of brain anatomy deviating from the normal pattern of growth and atrophy, such as in Alzheimer's disease (AD), has the potential to improve clinical outcomes through early intervention.

  20. Visual impairment in Alzheimer's disease: a critical review

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2010-01-01 Risk factors

    Visual impairment is a common symptom of Alzheimer's disease (AD).

  21. Risk factors for dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the Formosan Medical Association = Taiwan yi zhi 2009-10-01 Prevention trials

    Dementia is a complex human disease. The incidence of dementia among the elderly population is rising rapidly worldwide.

  22. Human brain networks in health and disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current opinion in neurology 2009-08-01 Brain scans and imaging

    Recent developments in the statistical physics of complex networks have been translated to neuroimaging data in an effort to enhance our understanding of human brain structural and functional networks.

  23. Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain structure & function 2009-06-30 Brain scans and imaging

    It is commonly assumed that functional brain connectivity reflects structural brain connectivity.

  24. Episodic simulation of future events is impaired in mild Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropsychologia 2009-06-02 Digital health tools

    Recent neuroimaging studies have demonstrated that both remembering the past and simulating the future activate a core neural network including the medial temporal lobes.

  25. Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participants

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2009-06-01 Brain scans and imaging

    The purpose of this paper is to establish single-participant white matter atlases based on diffusion tensor imaging.

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