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Home › Research › Brain scans and imaging

Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia

Mikko P. Laakso, Kaarina P. L. Partanen, Paavo Riekkinen, Maarit Lehtovirta, E.-L. Helkala, Merja Hallikainen, Tuomo Hänninen, Pauli A. Vainio et al.. Neurology, 1996-03-01

This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain scans and imaging

Topic: Brain imaging, connectivity and assessment

Hippocampal atrophy detected by volumetric MRI is a sensitive feature of early Alzheimer's disease (AD), but there are no studies evaluating hippocampal atrophy by MR volumetry in other dementing diseases. We therefore compared hippocampal volumes in a total of 113 subjects: 50 patients with mild to moderate AD, 9 patients with vascular dementia (VaD), 12 patients with idiopathic Parkinson's disease (PD) without dementia, 8 patients with PD and dementia (PDD), and 34 elderly control subjects. Thin, coronal, contiguous images were obtained by a 1.5-T MR imager. All patient groups had significantly smaller volumes of the hippocampus compared with the control group. In the PDD group, the absolute volumes were even smaller than in the AD group. In the PD group, the volumes were diminished to a lesser but significant extent. The volumes in the VaD group varied: of nine patients, two had no atrophy, three had unilateral, and four had bilateral atrophy. We postulate that hippocampal atrophy does not seem to be a specific phenomenon of dementia in AD but also occurs in VaD and PDD, and even in PD when no dementia is present. However, coexistence of AD pathology in our PD and VaD patients cannot be ruled out. Further studies with access to neuropathologic data are needed.

Key findings

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Study details

How this study scored 48/100
How this study's score is builtJournal tier 9 of 10; Journal's citation record left out, no data; Study design 0 of 12; Strength of evidence 1 of 5; Peer-review validation 10 of 10; How recent 1 of 5; Sample size 2 of 4; Effect reported 0 of 3; Studied in people 3 of 3; Randomised / blinded 0 of 2; Times cited left out, no data; Citations per year left out, no data; Impact for its field and year left out, no data; Cited by studies here left out, no data; Still being cited left out, no data; Senior author's track record left out, no data; Institution's track record left out, no data; Multi-centre collaboration left out, no data; Indexed in PubMed 2 of 2; Free to read 0 of 2. 28 of the 58 points it could be judged on, which is 48 of 100. Total 48 of 100.28 of the 58 points we could judge = 48 of 100

Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 28 of the 58 points we could judge it on, which is 48 out of 100.

ComponentPointsWhy
Journal tier 9 / 10 Tier 2 — leading specialty journal (Neurology)
Journal's citation record — / 4 No journal record from OpenAlex — left out of this score
Study design 0 / 12 No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence 1 / 5 Rated “low” in our summary
Peer-review validation 10 / 10 Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent 1 / 5 1996 — older than 20 years, still counted
Sample size 2 / 4 113 participants
Effect reported 0 / 3 No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people 3 / 3 Studied in people (participant count stated)
Randomised / blinded 0 / 2 No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited — / 7 No citation count (not found in OpenAlex) — left out of this score
Citations per year — / 5 No citation count or no year — left out of this score
Impact for its field and year — / 6 No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here — / 6 Not yet checked against this library's citation graph — left out of this score
Still being cited — / 4 No yearly citation counts — left out of this score
Senior author's track record — / 4 Senior author's record not available — left out of this score
Institution's track record — / 3 No institution listed in OpenAlex — left out of this score
Multi-centre collaboration — / 3 Institutions not listed — left out of this score
Indexed in PubMed 2 / 2 Indexed in PubMed (PMID 8618666)
Free to read 0 / 2 Behind a paywall — scores zero
Points 28 / 58 Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 28 of the 58 points we could judge it on is 48 out of 100.
Total 48 / 100 —

What each of these 20 components measures, and what this score is not →

Read the original

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Laakso, M. P., Partanen, K. P. L., Riekkinen, P., Lehtovirta, M., Helkala, E.-L., Hallikainen, M., et al. (1996). Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia. Neurology. https://doi.org/10.1212/wnl.46.3.678

Vancouver

Laakso MP, Partanen KPL, Riekkinen P, Lehtovirta M, Helkala E.-L, Hallikainen M, et al. Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia. Neurology. 1996. doi:10.1212/wnl.46.3.678. PMID: 8618666.

BibTeX

@article{laakso1996-8618666,
  author  = {Laakso, Mikko P. and Partanen, Kaarina P. L. and Riekkinen, Paavo and Lehtovirta, Maarit and Helkala, E.-L. and Hallikainen, Merja and Hänninen, Tuomo and Vainio, Pauli A. and others},
  title   = {{Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia}},
  journal = {Neurology},
  year    = {1996},
  doi     = {10.1212/wnl.46.3.678},
  pmid    = {8618666},
  url     = {https://doi.org/10.1212/wnl.46.3.678}
}

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