Home › Research › Cognitive tests and assessment
Real world clinical practice of lecanemab at PUMCH dementia cohort: focus on dynamic imaging and biomarker evolution
Chenhui Mao, Wenjun Wang, Xinying Huang, Meiqi Wu, Yifei Wang, Tianyi Wang, Yuyue Qiu, Shanshan Chu et al.. Alzheimer s Research & Therapy, 2026-01-10
Topic: Risk, prevention and care in population studies
A significant median Centiloid reduction of 30.9 was observed, with a 24.1% amyloid PET negativity rate after six months. While scores on cognitive and functional scales (CDR-SB, ADL) significantly worsened, indicating disease progression, the rate of progression was significantly slower compared to the control group. Structural MRI showed significant volume reduction in multiple brain regions and increased ventricular volume post-treatment, with no statistically significant change in the ALPS value.
Key findings
- A significant median Centiloid reduction of 30.9 was observed, with a 24.1% amyloid PET negativity rate after six months.
- While scores on cognitive and functional scales (CDR-SB, ADL) significantly worsened, indicating disease progression, the rate of progression was significantly slower compared to the control group.
- Structural MRI showed significant volume reduction in multiple brain regions and increased ventricular volume post-treatment, with no statistically significant change in the ALPS value.
Why it matters
In this real-world cohort, lecanemab reduced amyloid on PET scans, and although cognitive and functional scores still worsened, the rate of progression was slower than in a control group. Brain imaging also showed volume reduction in several regions and increased ventricular volume after treatment.
Study details
- Participants42
- Effect size24.1%; 7.1%
- Evidence strengthModerate
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 46 of the 96 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s Research & Therapy) |
| Journal's citation record | 1 / 4 | Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 1 / 4 | 42 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.5 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 4 / 6 | Cited 12.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author Jing Gao holds only 4 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 1 / 3 | Chinese Academy of Medical Sciences & Peking Union Medical College: institution h-index 950 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41520099) |
| Free to read | 2 / 2 | Free to read |
| Points | 46 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 46 of the 96 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s13195-025-01943-z
- PubMed: 41520099
- Original source →
- Free full text: Alzheimer s Research & Therapy →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Mao, C., Wang, W., Huang, X., Wu, M., Wang, Y., Wang, T., et al. (2026). Real world clinical practice of lecanemab at PUMCH dementia cohort: focus on dynamic imaging and biomarker evolution. Alzheimer s Research & Therapy. https://doi.org/10.1186/s13195-025-01943-z
Vancouver
Mao C, Wang W, Huang X, Wu M, Wang Y, Wang T, et al. Real world clinical practice of lecanemab at PUMCH dementia cohort: focus on dynamic imaging and biomarker evolution. Alzheimer s Research & Therapy. 2026. doi:10.1186/s13195-025-01943-z. PMID: 41520099.
BibTeX
@article{mao2026-41520099,
author = {Mao, Chenhui and Wang, Wenjun and Huang, Xinying and Wu, Meiqi and Wang, Yifei and Wang, Tianyi and Qiu, Yuyue and Chu, Shanshan and others},
title = {{Real world clinical practice of lecanemab at PUMCH dementia cohort: focus on dynamic imaging and biomarker evolution}},
journal = {Alzheimer s Research \& Therapy},
year = {2026},
doi = {10.1186/s13195-025-01943-z},
pmid = {41520099},
url = {https://doi.org/10.1186/s13195-025-01943-z}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
1 study in the alzhub library lists this one in its references.
Related studies in Cognitive tests and assessment
Also tagged “double-blind”
783 studies in the library carry the topic tag “double-blind”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 783 tagged studies.