Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Download bibliography of all 8,018 studies, highest score first: BibTeX (.bib) · RIS (.ris)
Highest usefulness score first. Studies without a score come last.
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Planning for the care of increasing numbers of elderly persons with dementia has become an urgent health services concern in Canada and elsewhere, yet little is known about the challenges of providing appropriate dementia care in rural areas.
Why it matters
This paper describes the development of a study of rural dementia care in Saskatchewan and reports findings from focus groups with home care staff and family members. It identifies barriers to family caregivers' use of formal services such as home care and support groups, but it does not test any treatment, cure, or prevention.
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The spectrum of mutations in this study can be used to plan appropriate screening protocols; a suggested protocol is to screen exon 4, and proceed to exons 3, 5, and 6 where indicated.
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25 of the patients needed a shunt operation.
Why it matters
In patients with normal pressure hydrocephalus, shunt placement relieved urinary incontinence and walking disability, and the positive effect remained over five years. The 16 patients who also had Alzheimer's disease did worse after one year, and the study concerns hydrocephalus rather than Alzheimer's treatment.
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Sixty-seven English language articles were obtained for the review, the majority of which (44, 65.7%) had US origins.
Why it matters
This review of 67 articles examined service needs, service provision, and models of good practice for minority ethnic groups in dementia care. It reports little consensus on whether services should be provided specifically for different ethnic groups and provides no evidence on treating, curing, or preventing Alzheimer's disease.
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Age, sex, functional and cognitive impairment and the diagnosis of pneumonia or congestive heart failure were the strongest predictors of death.
Why it matters
In nursing home residents with Parkinson's disease, half died within three years, and older age, male sex, severe functional or cognitive impairment, vision problems, pressure ulcers, congestive heart failure, diabetes, and pneumonia predicted death. This is about predicting mortality in long-term care, not about treating, curing, or preventing Alzheimer's disease.
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This simple cost-effective case-finding method can be of practical use in the development of community based dementia care services in India and other developing countries with similar health care systems.
Why it matters
This study trained community health workers in rural Kerala to identify possible dementia cases, and 33 of 51 suspected cases met DSM-IV criteria for dementia. It is about a community case-finding method, not about treating, curing, or preventing Alzheimer's disease.
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40/100
Neuropsychiatric features characterize frontotemporal dementia (FTD).
Why it matters
This review of 53 frontotemporal dementia patients found only one-third met consensus criteria at presentation, and it concludes the criteria need further refinement. It concerns diagnosis of frontotemporal dementia and does not address treating, curing, or preventing Alzheimer's disease.
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40/100
The psychosocial burden was recorded by the 15-item Relatives' Stress Scale (RSS).
Why it matters
This study measured the psychosocial burden on spouses of elderly people with stroke, mild dementia or Parkinson's disease using the Relatives' Stress Scale. It is about caregiver burden, not about treating, curing or preventing Alzheimer's disease.
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Cognitive function appears to be a marker of capacity for survival in the UK.
Why it matters
In this large multicentre UK study, each lower score on the Mini-Mental State Examination was linked to a strong and consistent reduction in survival, and adjustment for other factors did not change this pattern. It describes cognitive function as a marker of survival and does not test a treatment, cure or prevention.
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Stroke is highly prevalent in long-term care.
Why it matters
This study examined stroke survivors in nursing homes and found that most were not receiving drug therapy for stroke prevention. It does not address the treatment, cure, or prevention of Alzheimer's disease.
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Anticholinergic toxicity is a common problem in the elderly.
Why it matters
This review states that anticholinergic toxicity in the elderly ranges from dry mouth and constipation to confusion, delirium, and severe cognitive decline, and is often due to the cumulative burden of multiple medications rather than a single compound. It recommends that management of elderly patients, particularly those with dementia, aim to reduce the use of medications with anticholinergic effects.
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The National Institutes of Health is making efforts to increase the representation of minority elders in aging research.
Why it matters
This qualitative study identified sociocultural barriers to recruiting Chinese-American family caregivers for dementia research, including viewing dementia as normal aging, fear of harm from participation, and social stigma. It addresses research participation, not the treatment, cure, or prevention of Alzheimer's disease.
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40/100
These data indicate that the burden of illness among people with arthritis is higher than for nonarthritics and that this burden appears to be increasing over time, particularly in RA.
Why it matters
This study describes the frequency of other medical conditions in people with rheumatoid arthritis and osteoarthritis compared with controls. It does not concern Alzheimer's disease at all and has no implications for treating, curing, or preventing it.
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Elderly people are more likely than younger patients to develop cognitive impairment as a result of taking medications.
Why it matters
This review notes that elderly people are more likely than younger patients to develop cognitive impairment from medications, and that delirium is the cognitive disturbance most clearly linked to drug toxicity. It concerns drug side effects rather than treating, curing or preventing Alzheimer's disease.
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The frontotemporal dementias are a group of relatively new and evolving clinical and pathologic entities.
Why it matters
This case report describes a patient with clinical and neuroimaging characteristics of cortical-basal ganglionic degeneration who was found to have the typical histologic features of frontotemporal dementia of the motor neuron disease-inclusion dementia subtype. The study did not report any outcomes related to treating, curing, or preventing Alzheimer's disease.
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Delusional misidentification and hallucinations in the early stages of dementia may improve differentiation between patients with dementia with Lewy bodies and those with Alzheimer's disease and have important treatment implications.
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40/100
ACS occurs in one fourth of stroke patients older than 40 years.
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The main determinants of healthcare use in the Netherlands are old age and disabling conditions, particularly mental disability.
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Elevated glucocorticoid levels produce hippocampal dysfunction and correlate with individual deficits in spatial learning in aged rats.
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40/100
Circulating glucose concentrations regulate many brain functions, including learning and memory.
Why it matters
This review reports that raising blood glucose with glucose or epinephrine can enhance some cognitive functions in elderly people and in people with Alzheimer disease or Down syndrome. It concerns temporary cognitive effects, not treating, curing or preventing the underlying disease.
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Intracranial vasculitis, or primary angiitis of the central nervous system (PACNS), is an uncommon, often fatal disorder that frequently responds to aggressive immunosuppressive therapy.
Why it matters
This study of patients undergoing brain biopsy to rule out vasculitis found that MRI and angiography changes were nonspecific and overlapped with changes from chronic hypertension and amyloid deposition. It is about diagnosing intracranial vasculitis, not about treating, curing, or preventing Alzheimer's disease.
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The Bayer Activities of Daily Living Scale (B-ADL) has been developed on an international basis to assess deficits in the performance of everyday activities.
Why it matters
This 1998 paper describes the Bayer Activities of Daily Living Scale, a 25-item questionnaire that a caregiver or other informant completes about everyday tasks in people living at home with mild cognitive impairment or mild-to-moderate dementia. Its items were picked from questions piloted in the USA, Germany, UK, Russia and Greece for their sensitivity to cognitive impairment and their relevance to daily life. The authors suggest it is short enough for GP practices to use for screening and for tracking treatment effects and progression. The paper describes the scale and does not report how well it performs.
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40/100
This article identifies and discusses criteria that can be used by health professionals to critically appraise research articles that estimate the prevalence or incidence of a disease or health problem.
Why it matters
This article sets out criteria for judging the quality of studies that measure how common a disease is, using dementia in Canada as an example. It is a methods guide and does not test any treatment, cure, or prevention.
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Current characteristics and perspectives of Brazilian demographic and epidemiological transition processes are analyzed.
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Institutionalized patients with Down syndrome (n = 307) were monitored for 5 to 10 years prospectively to determine prevalence of Alzheimer-type dementia.
Why it matters
Among 307 people with Down syndrome living in institutions who were followed for 5 to 10 years, dementia became more common with age, rising from 11% at ages 40 to 49 to 77% at ages 60 to 69, with a mean age at onset of 56. A dementia checklist, cognitive skills inventory and EEG reliably detected dementia at an early stage in this group.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Neuropathological assessment of the lesions of significance in vascular dementia
- Effects of a virtual iSupport Program on carers and people with dementia
- Smaller hippocampal volume in Dutch police officers with posttraumatic stress disorder
- Dual-task performances can be improved in patients with dementia: a randomized controlled trial
- The joint association of obesity and physical activity on cognitive function in Down syndrome
- Investigating Modifiable Factors Associated with Cognitive Decline: Insights from the UK Biobank
- Examining multimorbidity contributors to dementia over time
- Nutrition in palliative care at the end of life: Bibliometric and network analysis until 2024
- Place of death for people with dementia: A scoping review
- Excessive daytime sleepiness and subsequent development of Parkinson disease