Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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47/100
Comparative effectiveness of behavioral interventions to mitigate the impacts of degeneration-based cognitive decline is not well understood.
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Even after accounting for established individual‐level demographic, socioeconomic, health, and genetic risk factors for cognitive decline, greater neighborhood disadvantage is associated with an accelerated rate of annualized decline in delayed recall performance across mid to late life in a community sample.
Why it matters
This study found that greater neighborhood disadvantage was linked to worse memory and faster memory decline in a community-based cohort. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Reproductive history events signaling more estrogen exposure such as premenopausal status, longer reproductive span, higher number of children, and use of HT and HC were associated with larger GMV in women in midlife.
Why it matters
In this study of midlife women and men, all menopausal groups had lower gray matter volume in Alzheimer-vulnerable brain regions than men, and several reproductive history factors were positively associated with gray matter volume. These indicators were not directly associated with cognitive measures, so the meaning for Alzheimer's risk is not yet clear.
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Aging is associated with chronic systemic inflammation, which contributes to the development of many age-related diseases, including vascular disease.
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A parallel mixed-methods study on 20 patient-caregiver dyads in an Asian population was conducted to explore the differential perceptions and barriers to ACP in dementia.
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We aimed to explore diagnoses associated with antipsychotic use, treatment patterns and characteristics of users without diagnoses relevant to antipsychotic treatment.
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Up to 7 August 2020, there were 29,542 (95% CI 25,176 to 33,908) excess deaths in all care homes.
Why it matters
This national cohort study found 29,542 excess deaths in English care homes during the first 23 weeks of the COVID-19 pandemic, with 64.7% of these confirmed or suspected COVID-19. The odds of COVID-19 attributable deaths were higher in homes providing nursing services and in homes for older people and/or people with dementia.
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Increased life expectancy combined with the aging baby boomer generation has resulted in an unprecedented global expansion of the elderly population.
Why it matters
This review describes how age-related hormonal decline is linked to chronic conditions including dementia, and states that hormone replacement therapy often causes adverse events that outweigh its benefits and is not recommended except in specific cases. It suggests positive lifestyle changes such as exercise and a healthy calorically restricted diet can favorably affect endocrine and body composition changes, but it does not show that any of these prevent Alzheimer's disease.
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Immersive VR was acceptable and enjoyable for older adults in both groups.
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This study reports findings from a series of focus groups with persons with dementia and family caregivers intended to explore: (1) perceptions of and experiences with advance care planning (ACP); (2) concerns related to future care including, but not limited to, end-of-life care; and (3) practices that may support positive engagement with ACP.
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In this exploratory sequential mixed-methods study, interviews with 125 adults aged 55-92 (mean age 71) living in the Minneapolis (Minnesota) metropolitan area suggested that eateries, including coffee shops and fast-food restaurants, represent popular neighborhood destinations for older adults and sources of wellbeing.
Why it matters
This study found that older adults often visit local eateries for social contact and wellbeing, and that more eateries in a neighborhood was linked to better cognitive functioning. It is an exploratory study and does not show that eateries cause better cognition or prevent dementia.
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Age-related hearing loss (ARHL) is a common problem for older adults, leading to communication difficulties, isolation, and cognitive decline.
Why it matters
This review states that hearing loss has recently been identified as potentially the most modifiable risk factor for dementia. It explores possible causal relationships between hearing loss, neural reorganisation, and cognitive impairment, aiming to inspire research and novel interventions.
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47/100
We hypothesize the population without dementia can be subdivided into participants with and without biological Alzheimer disease (AD) based on the combination of CSF Aβ42 and p-tau/t-tau (represented also by the p-tau/t-tau/Aβ42 ratio).
Why it matters
In 774 participants, relationships between cerebrospinal fluid amyloid and tau markers fell into two subgroups, with one subgroup linked to older age, APOE ε4, mild cognitive impairment and elevated amyloid PET. This is an observational biomarker study and does not test any treatment, cure or prevention.
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Approximately 2% of those aged ≥60 years had dementia, lower than published estimates.
Why it matters
This study estimated that about 2% of people aged 60 and over in New Zealand had dementia, which is lower than previous estimates. It highlights the need for further work to improve future estimates, but it does not provide information on treating, curing, or preventing Alzheimer's disease.
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Aging induces cellular and molecular changes including modification of stem cell pools.
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As the population ages, the number of people with dementia is expected to increase in the coming decades, with consequences at the societal and individual levels.
Why it matters
This narrative review summarizes evidence on dementia prevention strategies such as treating cardiovascular disease, staying mentally and socially active, and healthy lifestyle habits like physical activity, not smoking and a balanced diet. It discusses possible biological reasons these strategies may work but reports no new treatment or cure.
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Sepsis is a major cause of death in intensive care units worldwide.
Why it matters
This review describes how sepsis can cause acute brain dysfunction and long-term cognitive deficits in survivors, with no specific therapeutic options yet available. It concerns cognitive impairment after sepsis rather than Alzheimer's disease, and it does not provide a treatment or cure.
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Fusing multi-modality data is crucial for accurate identification of brain disorder as different modalities can provide complementary perspectives of complex neurodegenerative disease.
Why it matters
This paper describes a multi-modal latent space ensemble SVM classifier for early dementia diagnosis using neuroimaging data. It is a methods development study, so it cannot show that any treatment would prevent or cure Alzheimer's disease.
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Our findings indicate a general agreement among professional stakeholders on the ethical promises and challenges raised by the use of IATs among older and disabled users.
Why it matters
Interviews with professional stakeholders identified patient autonomy and informed consent, data management quality, distributive justice, and human contact as ethical priorities for intelligent assistive technology in dementia care. The study concerns ethical issues in technology development and use, not treating, curing, or preventing Alzheimer's disease.
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Electroencephalographic (EEG) recordings generate an electrical map of the human brain that are useful for clinical inspection of patients and in biomedical smart Internet-of-Things (IoT) and Brain-Computer Interface (BCI) applications.
Why it matters
A machine learning approach using EEG features classified healthy controls versus patients with mild cognitive impairment or Alzheimer's disease, with one classifier performing best. This is a diagnostic classification study and does not test any treatment, cure, or prevention.
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Providing peer-support groups using telehealth may have the potential to develop self-sustaining peer networks for isolated caregivers of people with dementia.
Why it matters
A peer-support programme delivered by group videoconferencing reached 69 isolated carers of people with dementia across Australia, with few technical issues. This is about supporting carers, not about treating, curing or preventing Alzheimer's disease.
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Higher adherence to the MedDiet is associated with better cognitive function and lower risk of poor cognition in older UK adults.
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There were 75 subjects in the pilot. The patients were aged 65 (56-73.5) years, and 39% (29/75) resided in rural areas.
Why it matters
This small pilot study tested home video visits for follow-up care after stroke and found they saved patients time and money and were well received. It does not test any treatment, cure, or prevention of Alzheimer's disease.
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Caregiving intensity is related to health for non-Latino White CGs and African American dementia CGs.
Why it matters
This study looked at how stress and support relate to health and distress among caregivers from three racial and ethnic groups. It found that caregiving intensity was related to health for some groups, which may help guide support for caregivers but does not treat or prevent Alzheimer's disease itself.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- How effective are interventions with caregivers? An updated meta-analysis
- Exercise programs for people with dementia
- Cardiovascular risk factors and dementia
- AI-powered model for accurate prediction of MCI-to-AD progression
- Social determinants of brain structure and cognition
- Cerebrospinal fluid abnormalities and rate of decline in everyday function across the dementia spectrum: normal aging, mild cognitive impairment, and Alzheimer disease
- Public health strategies for hepatocellular carcinoma: from risk factors to prevention and control
- Addressing healthy aging in China: Practices and prospects
- Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly
- Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial