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Trajectory of Cardiogenic Dementia: A New Perspective
Nawaf Farhan Alrawili, Hayder Mutter Al-Kuraishy, Ali Ismail Al-Gareeb, Maha M. Abdel‐Fattah, Nasser A. Al‐Harchan, Mubarak Alruwaili, Marios Papadakis, Athanasios T. Alexiou et al.. Journal of Cellular and Molecular Medicine, 2025-01-01
Topic: Risk, prevention and care in population studies
The functions of the heart and brain are closely linked and essential to support human life by the heart-brain axis, which is a complex interconnection between the heart and brain. Also, cardiac function and cerebral blood flow regulate the brain's metabolism and function. Therefore, deterioration of cardiac function may affect cognitive function and may increase the risk of dementia. Cardiogenic dementia is defined as a cognitive deterioration due to heart diseases such as heart failure, myocardial infarction, and atrial fibrillation. The prevalence of cognitive impairment in patients with heart failure was 29%. In addition, coronary artery disease (CAD) is also associated with the development of cognitive impairment. CAD and reduction of myocardial contractility reduced cerebral blood flow and increased the risk of dementia in CAD patients. Furthermore, myocardial infarction and subsequent systemic haemodynamic instability promote the development and progression of cardiogenic dementia. These findings indicated that many cardiac diseases are implicated in the development and progression of cognitive impairment. Nevertheless, the underlying mechanism for the development of cardiogenic dementia was not fully elucidated. Consequently, this review aims to discuss the potential mechanisms involved in the pathogenesis of cardiogenic dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Alrawili, N. F., Al-Kuraishy, H. M., Al-Gareeb, A. I., Abdel‐Fattah, M. M., Al‐Harchan, N. A., Alruwaili, M., et al. (2025). Trajectory of Cardiogenic Dementia: A New Perspective. Journal of Cellular and Molecular Medicine. https://doi.org/10.1111/jcmm.70345
Vancouver
Alrawili NF, Al-Kuraishy HM, Al-Gareeb AI, Abdel‐Fattah MM, Al‐Harchan NA, Alruwaili M, et al. Trajectory of Cardiogenic Dementia: A New Perspective. Journal of Cellular and Molecular Medicine. 2025. doi:10.1111/jcmm.70345. PMID: 39828641.
BibTeX
@article{alrawili2025-39828641,
author = {Alrawili, Nawaf Farhan and Al-Kuraishy, Hayder Mutter and Al-Gareeb, Ali Ismail and Abdel‐Fattah, Maha M. and Al‐Harchan, Nasser A. and Alruwaili, Mubarak and Papadakis, Marios and Alexiou, Athanasios T. and others},
title = {{Trajectory of Cardiogenic Dementia: A New Perspective}},
journal = {Journal of Cellular and Molecular Medicine},
year = {2025},
doi = {10.1111/jcmm.70345},
pmid = {39828641},
url = {https://doi.org/10.1111/jcmm.70345}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- In addition, coronary artery disease (CAD) is also associated with the development of cognitive impairment.
- These findings indicated that many cardiac diseases are implicated in the development and progression of cognitive impairment.
Why it matters
This review discusses how heart diseases such as heart failure, myocardial infarction, and atrial fibrillation may affect cognitive function and increase dementia risk through the heart-brain axis. It notes that the underlying mechanism for cardiogenic dementia is not fully elucidated.
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Study details
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Cellular and Molecular Medicine) |
| Journal's citation record | 2 / 4 | Journal of Cellular and Molecular Medicine: journal h-index 187 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 17 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 4 / 6 | Cited 10.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Gaber El‐Saber Batiha: h-index 72 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Witten/Herdecke University: institution h-index 335 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 9 institution(s) in 5 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39828641) |
| Free to read | 2 / 2 | Free to read |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1111/jcmm.70345
- PubMed: 39828641
- Original source →
- Free full text: Journal of Cellular and Molecular Medicine →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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