Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Spatial version of multivariate Fay–Herriot model is introduced and small area predictor under this model is proposed.
Why it matters
This study is about a statistical model for small area estimation, not Alzheimer's disease, so it does not provide information on treating, curing or preventing Alzheimer's. It found that the proposed predictor performed better than existing predictors in simulations.
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Spatial version of multivariate Fay–Herriot model is introduced and small area predictor under this model is proposed.
Why it matters
This study is about a statistical model for small area estimation, not Alzheimer's disease, so it does not provide information on treating, curing or preventing Alzheimer's. It found that the proposed predictor performed better than existing predictors in simulations.
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Controlling for beneficiary, local, and state characteristics, we found the following factors to be associated with beneficiaries spending less time in nursing homes: fewer nursing home beds in the county, higher state Medicaid long-term care spending for home and community-based services (HCBS), and state use of Certificate of Need laws.
Why it matters
This national study of Medicare beneficiaries with Alzheimer's disease and related dementias found regional variation in where people spent time after diagnosis, with beneficiaries in Midwestern states spending the most time in nursing homes. Fewer nursing home beds in the county and higher state Medicaid spending on home and community-based services were associated with less time in nursing homes.
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There are few published data available about simultaneous bilateral hip fractures.
Why it matters
This is a single case report of a man with Down syndrome and Alzheimer-like dementia who had one-stage surgery for bilateral hip fractures and walked unaided afterward. It offers no information about treating, curing, or preventing Alzheimer's disease itself.
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The primary pharmacy system and health support pharmacy system were established in 2016.
Why it matters
This paper describes pharmacies in Japan that combine convenience store features with care consulting services, where care workers hold monthly events including on dementia prevention. It is a description of a service model and does not report evidence that this model prevents or treats dementia.
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The mechanism of action of benzodiazepines is through the modulation of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that suppresses the central nervous system (CNS); the drugs have efficacy for short-term use (less than 1 month), but patients can develop a tolerance and dependence with long-term use.2 The benefits of benzodiazepines decrease over time and there are increased associated risks such as cognitive decline, accidental injuries, falls, and increased rates of hospital admissions and ED visits.2 Patients can also have paradoxical anxiety while on benzodiazepines.3 Studies have shown that long-term use of benzodiazepines increases the risk of dementia.4,5 Recent clinical practice guidelines recommend deprescribing benzodiazepines for older adults (age 65 years or older) for use in insomnia, and the American Geriatric Society (AGS) BEERs Criteria recommend avoidance of benzodiazepines in older adults because of the increased risk of adverse reactions such as falls and fractures.1,6 The AGS does say that benzodiazepines may be appropriate for use in older adults in certain circumstances such as ethanol withdrawal, and periprocedural anesthesia.6 The FDA has cautioned providers about prescribing benzodiazepines in patients using opioids but does not recommend withholding medications used for opioid use disorder in patients taking benzodiazepines.7,8 NPs can be instrumental in adequately treating anxiety and insomnia disorders with nonpharmacologic interventions (such as yoga and sleep hygiene) as well as with other medication classes that are not benzodiazepines.
Why it matters
This article discusses deprescribing benzodiazepines in older adults, noting that long-term use increases the risk of dementia and that guidelines recommend avoidance in older adults. It suggests that reducing benzodiazepine use may lower a risk factor associated with dementia, but does not test a treatment or cure.
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As has been noted, Alzheimer’s and related dementias are underdiagnosed and when diagnoses are made, they are too often undisclosed by clinicians: studies suggest that fewer than half of individuals report being told of their diagnoses (Alzheimer’s Association, 2015).
Why it matters
This article discusses public policy changes aimed at improving detection, diagnosis, and care planning for Alzheimer's and related dementias. It does not test any treatment, cure, or prevention.
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Self-reported changes in physical and mental health by members are an important dimension by which the quality of a Medicare Advantage (MA) plan is rated by the Centers for Medicare & Medicaid Services.
Why it matters
This study found that dementia was associated with self-reported worsening of both overall physical health and overall mental health in a Medicare Advantage plan population. It suggests that Medicare Advantage plans could use chronic condition information to target interventions for members.
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Health concerns seem to influence consumers’ decisions for purchasing local foods.
Why it matters
This study examined how health concerns, including family history of Alzheimer's or dementia, affect consumers' decisions to buy local foods. It is about food purchasing behavior and does not test any treatment, cure, or prevention for Alzheimer's disease.
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28/100
Life experience, poetry, fiction, and neuroscience have all demonstrated the incomplete fragmentary nature of memory.
Why it matters
This memoir fragment notes that memory is incomplete and fragmentary, drawing on life experience, poetry, fiction, and neuroscience. It contains no findings on treating, curing, or preventing Alzheimer's disease.
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A fifteen-year follow up of the linguistic and cognitive profile of a woman, named Françoise, with standard trisomy 21.
Why it matters
This fifteen-year follow-up of one woman with trisomy 21 documents declining language abilities that resemble early Alzheimer's disease. As a single-person descriptive report, it offers no information on treating, curing or preventing Alzheimer's disease.
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Symptoms of mania have been given inadequate attention as a source of agitated behavior in the dementia patient.
Why it matters
In a case series of three elderly patients with dementia and mania refractory to psychotropic medications, right-unilateral electroconvulsive therapy improved signs of mania and agitation as well as mental status scores. The authors conclude that a short course of ECT followed by maintenance treatments every two weeks can contribute significantly to managing dementia patients whose behavioral agitation is associated with signs of mania.
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Its collective ethos and measurable outputs provide a working model for advancing an Asian approach to mental health transformation, one that is equitable, culturally grounded, and globally relevant.
Why it matters
This article describes a collective effort toward an Asian approach to mental health transformation and reports no datasets were generated or analyzed. It contains no information on treating, curing, or preventing Alzheimer's disease.
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It is thought that every elderly has at least one dermatological problem.
Why it matters
This section discusses dermatological problems and treatment in long-term and nursing-home care, focusing on pressure injuries. It provides no information on treating, curing or preventing Alzheimer's disease.
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These findings highlight the variability in the cumulative patterning of racial discrimination and stress among midlife and older Black adults, providing insights into how these factors impact health outcomes in middle to late life.
Why it matters
This symposium summary reports that living in neighborhoods with low income, low vehicle access, and higher low-fat milk prices was linked to a greater risk of incident dementia. It describes associations only and does not test any treatment, cure, or prevention.
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27/100
Puerto Rico is experiencing a rapidly aging population due to outmigration and other demographic changes.
Why it matters
This symposium describes that older adults in Puerto Rico have higher rates of dementia and depressive symptoms than those on the US mainland while receiving less federal funding for Medicare and Medicaid. It is a description of care dynamics and funding gaps, not a study of any treatment, cure or prevention.
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Riverside Health has developed a new palliative care pathway to serve as an innovative standard of person-centered care for persons living with dementia (PLWD) and their care partners.
Why it matters
This abstract describes a new palliative care pathway at Riverside Health that added a social worker, geriatric pharmacist, and spiritual care advisor to an existing team, plus dementia-specific training and microlearning lessons. The enhanced team served more than 175 people with dementia and their family caregivers, with reported increases in quality of life and well-being.
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Advance care planning aims to allow individuals to discuss their goals and preferences for future medical and nursing care with family members and medical personnel in advance when they still have decision-making ability, so that individuals can receive medical care that meets their preferences when they lose their decision-making ability.
Why it matters
This review summarises intervention strategies for advance care planning in dementia patients, mostly face-to-face structured discussions about disease understanding, future care goals and preferences. It is about care planning, not treating, curing or preventing Alzheimer's disease.
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Introdução: Com o aumento da expectativa de vida e do percentual de idosos no país, também está crescendo a taxa de doenças neurodegenerativas.
Why it matters
This literature review reports that combining measurements of Aβ42, Tau and p-Tau with newer plasma biomarkers such as p-Tau181 and NfL offers potential for earlier and more accurate diagnosis of Alzheimer's disease. It also notes promising markers for Parkinson's disease and multiple sclerosis, but this is a review of diagnostic markers and does not report a treatment, prevention or cure for Alzheimer's disease.
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Eligible studies used many study designs with different sample sizes.
Why it matters
This scoping review found great variation in dementia rehabilitation services, with some showing promising but no longer-term effects. It addresses rehabilitation for people living with early stage dementia, not curing or preventing Alzheimer's disease.
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Cognitive impairment in the elderly causes a decrease in the ability to do various things related to thinking and remembering.
Why it matters
In this study of 62 elderly people with dementia, nine sessions of Scrabble game therapy significantly improved cognitive capacity as measured by the MMSE. The eighth session showed a significant improvement.
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The components of the MIND diet should be evaluated in relation to the dietary habits and cultural background of the population being studied.
Why it matters
This study assessed how well healthcare workers followed the MIND diet and found their adherence was unexpectedly low. It reports on dietary habits only and does not test whether the MIND diet treats, cures, or prevents Alzheimer's disease.
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Introducción: la enfermedad de Alzheimer (EA) se define como un trastorno neurodegenerativo caracterizado por acumulación de placas beta amiloide a nivel cerebral, lo cual ocasiona alteraciones histopatológicas y se manifiesta, principalmente, en el deterioro cognitivo (DC).Objetivo: evaluar el efecto de lecanemab sobre el DC en pacientes con EA.Material y métodos: metaanálisis de artículos originales que evaluaron el DC durante los periodos de intervención con placebo y lecanemab.
Why it matters
This meta-analysis of 5,069 subjects found that lecanemab 10 mg/kg every two weeks significantly reduced cognitive decline in patients with Alzheimer disease, with more favourable results at 18 months than at 12 months. It supports lecanemab as a treatment for cognitive decline in these patients.
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27/100
Dementia encompasses a group of progressive neurodegenerative disorders marked by cognitive, behavioural, and functional decline, underpinned by complex neurobiological processes.
Why it matters
This chapter describes dementia as a multifactorial disorder involving neuroinflammation, mitochondrial dysfunction, oxidative stress, impaired protein clearance and synaptic loss, alongside proteinopathies and vascular contributions. It states that these insights are driving development of biomarkers and disease-modifying therapies, but reports no treatment results.
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Dementia is a progressive condition that gradually impairs cognitive function, memory, and daily living skills.
Why it matters
This overview says dementia is progressive and affects not only the individual but also families and caregivers, and that about 1.2 million people in Indonesia currently live with dementia. It argues that palliative care, by prioritizing symptom management, psychological support, and respect for patient autonomy, can help alleviate suffering and promote well-being.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- AAC for adults with acquired neurological conditions: a review
- Classification criteria for mild cognitive impairment: a population-based validation study
- Marked gender differences in progression of mild cognitive impairment over 8 years
- Development of a new measure of health-related quality of life for people with dementia: DEMQOL
- Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study
- Increased Precision in County-Level Volume Estimates in the United States National Forest Inventory With Area-Level Small Area Estimation
- Resource-stratified machine learning framework for cognitive status classification and mild cognitive impairment to dementia progression prediction
- MRI markers of cerebrospinal fluid dynamics predict dementia and mediate the impact of cardiovascular risk
- Risk factors for falls in HIV-infected persons
- Association between chronic pain and risk of incident dementia: findings from a prospective cohort