Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Dogs develop cognitive decline and a progressive accumulation of oxidative damage.
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The speech of patients with progressive non-fluent aphasia (PNFA) has often been described clinically, but these descriptions lack support from quantitative data.
Why it matters
This analysis of conversational speech in 15 patients with progressive aphasia found consistent increases in grammatical and speech sound errors and simplified syntax, with slow speech common but not universal. It suggests progressive non-fluent aphasia is a coherent syndrome with continuous variation among subtypes, and reports nothing about treating, curing, or preventing Alzheimer's disease.
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The effects of early life experience on later brain structure and function have been studied extensively in animals, yet the relationship between childhood experience and normal brain development in humans remains largely unknown.
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Further investments to facilitate dying at home are desirable.
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In patients who were delirious at the time of PAC admission, persistent delirium was a significant independent predictor of 1-year mortality.
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We used Cox proportional hazard analyses to examine prospective predictors of driving cessation over a 3-year period.
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Immobility-related complications are very common in the first year after a severely disabling stroke.
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Overall, our results suggest that a relatively small hippocampal volume may be a vulnerability factor for a bad treatment response in major depression.
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Serious events, as indicated by a hospital admission or death, are frequent following the short-term use of antipsychotic drugs in older adults with dementia.
Why it matters
This large cohort study found that older adults with dementia who were newly given antipsychotic therapy were more likely to have a serious event such as hospital admission or death within 30 days than those who received no antipsychotic therapy. It is about the short-term risks of these medications, not a treatment or cure for dementia.
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Hippocampal volumes were reduced in PT infants exposed to several perinatal events but were preserved in PT infants without these exposures.
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Dementia is an important and increasingly recognized problem in Parkinson's disease (PD).
Why it matters
This study compared scores on the Mini-Mental State Examination and the Montreal Cognitive Assessment in 88 patients with Parkinson's disease, finding a pronounced ceiling effect with the MMSE but not the MoCA. It is about detecting cognitive deficits, not about treating, curing or preventing Alzheimer's disease.
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Mr M, a patient with semantic dementia--a neurodegenerative disease that is characterized by the gradual deterioration of semantic memory--was being driven through the countryside to visit a friend and was able to remind his wife where to turn along the not-recently-travelled route.
Why it matters
This paper discusses the representation of semantic knowledge in the human brain, illustrated by a patient with semantic dementia. It explores what goes wrong in the brain to cause a selective loss of conceptual knowledge.
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Rates of atrophy accelerate as individuals progress from amnestic mild cognitive impairment (aMCI) to typical late onset Alzheimer disease (AD).
Why it matters
In people with amnestic mild cognitive impairment who progressed to Alzheimer disease, the rate of brain shrinkage and ventricle enlargement sped up around the time of diagnosis. This describes how atrophy changes over the course of illness and does not test any treatment.
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Spatial patterns of brain atrophy in mild cognitive impairment (MCI) and Alzheimer's disease (AD) were measured via methods of computational neuroanatomy.
Why it matters
Using a computer-based analysis of brain scans, about two-thirds of people with mild cognitive impairment had atrophy patterns resembling Alzheimer's disease, and those people showed a higher rate of cognitive decline. This pattern classification could potentially help predict who will decline faster, but it does not provide a treatment or cure.
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Our results suggest that genes associated with clinical neurological disease also have detectable effects on subclinical phenotypes.
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This paper describes DARTEL, an algorithm for diffeomorphic image registration implemented for both 2D and 3D images with an option for estimating inverse consistent deformations.
Why it matters
Describes a fast diffeomorphic image registration algorithm, a computer method for aligning images.
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Tests of both episodic memory and executive function are predictors of time to progression from mild impairment to a clinical diagnosis of Alzheimer disease.
Why it matters
Among cognitively normal individuals, lower scores on tests of episodic memory predicted progression to mild impairment, and apolipoprotein E epsilon2 status was associated with lower risk of cognitive decline. These findings concern prediction of cognitive decline, not treatment or prevention.
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Structural brain changes in anatomic areas involved in higher cognitive processes precede clinical signs and symptoms in longitudinally followed normal subjects destined to develop mild cognitive impairment.
Why it matters
In this study, initially normal older adults who later developed mild cognitive impairment already showed decreased gray matter volumes in the anteromedial temporal lobes and left angular gyrus while still cognitively normal. This suggests structural brain changes can precede clinical symptoms, but it does not show how to prevent them.
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The life expectancy of patients who have dementia and are initiated on dialysis in the United States has not been described in the medical literature.
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Despite the growing number of persons with advanced dementia, and the need to improve their end-of-life care, few studies have addressed this important topic.
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Although the clinical course of Alzheimer disease (AD) is gradual, it is useful for a number of reasons to distinguish between different levels of severity.
Why it matters
This study mapped Mini-Mental State Examination scores onto Clinical Dementia Rating categories to see how well the MMSE works as a timesaving way of staging dementia. It concerns staging and assessment, not treating, curing, or preventing Alzheimer's disease.
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The correct diagnosis of Parkinson's disease is important for prognostic and therapeutic reasons and is essential for clinical research.
Why it matters
This paper reports that clinicians misdiagnose Parkinson's disease in about 25% of patients in brain bank studies, with essential tremor, vascular parkinsonism and atypical parkinsonian syndromes as common reasons. It concerns diagnosis of Parkinson's disease and offers nothing on treating, curing or preventing Alzheimer's disease.
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The gender-specific results for obesity, but not for diabetes, suggests that the underlying mechanisms linking them to cognition may be different.
Why it matters
In this prospective study, adverse effects of obesity on cognitive performance were observed for men only, and diabetes-years related to poorer cognitive performance only when men and women were combined. The gender-specific results for obesity, but not for diabetes, suggest that the mechanisms linking them to cognition may be different.
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52/100
There is considerable variation in the phenotypic appearance of individuals with idiopathic Parkinson's disease (PD), which may translate into differences in disease progression in addition to underlying disease etiology.
Why it matters
This study followed 162 people newly diagnosed with Parkinson's disease in mostly rural central California (1998–2003) and found that within 3 years, 17% met criteria for mild dementia and 13% showed some signs of depression. Most had stiffness (92.0%), slowness (95.7%) and walking problems (87.0%), but fewer than half (43.3%) had a tremor, so a missing tremor did not rule out Parkinson's in this group. It describes one regional group of patients without a comparison group, so it shows what early Parkinson's looked like there, not anyone's personal risk, and it is not a study of Alzheimer's disease.
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None of the clinical criteria for VaD identified the same group of subjects.
Why it matters
This study describes how cases of vascular dementia were classified in a large community cohort, showing that different diagnostic criteria produce different numbers of cases. It is about diagnosis and classification, not about treating, curing, or preventing Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Sleep disturbances as risk factors for neurodegeneration later in life
- Hearing Loss and Falls
- The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial
- The role of cognitive impairment in fall risk among older adults: a systematic review and meta-analysis
- Use of Artificial Intelligence, Internet of Things, and Edge Intelligence in Long-Term Care for Older People: Comprehensive Analysis Through Bibliometric, Google Trends, and Content Analysis
- Association of multimorbidity and disease clusters with neuroimaging and cognitive outcomes in UK Biobank
- Incidence and Risk of Stroke following Dementia: A Nationwide Cohort Study in South Korea
- Care Dynamics of Puerto Rico’s Older Adults: Dementia, Caregiving, Mental Health, and Outmigration
- The Impact of Self-Store Image Congruency on Consumer Engagement and Store Attachment in the Grocery Retail Sector in Kuwait
- Extension and external validation of mapping between the Mini‐Mental State Examination and the Clinical Dementia Rating scale in patients with Alzheimer's disease