Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Download bibliography of all 8,018 studies, highest score first: BibTeX (.bib) · RIS (.ris)
Highest usefulness score first. Studies without a score come last.
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Higher offspring education (> 12 years) was associated with higher baseline cognitive scores and faster cognitive decline.
Why it matters
This study found that higher offspring education was associated with higher baseline cognitive scores and a reduced risk of cognitive impairment or probable dementia, particularly among Hispanic participants. It does not test any treatment or cure, but suggests that offspring education may be linked to cognitive health in older adults.
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We observed no mediation of individual risk factors in the effect of the interventions on dementia incidence.
Why it matters
In these two large prevention trials, the interventions did not lower dementia incidence, and changes in individual risk factors did not explain the results. The interventions slightly lowered only blood pressure, but this did not translate into less dementia.
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=0.002). Early-onset CHD and genetic susceptibility are associated with a higher risk of incident dementia and a larger WMH volume.
Why it matters
This prospective cohort study found that early-onset coronary heart disease and genetic susceptibility were associated with higher risk of incident dementia and larger white matter hyperintensity volume. It suggests paying attention to the cognitive status of people with early-onset coronary heart disease, but does not test a treatment or prevention.
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47/100
China accounts for 1/5 of the global population and China faces a particularly heavy dementia burden due to its rapidly ageing population.
Why it matters
This review summarises community-based cohort studies of dementia in the Chinese population and identifies research gaps and future directions. It is about improving research methodology and evidence, not treating, curing, or preventing Alzheimer's disease.
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All concurrent validity correlations followed the expected directionality, with 19/21 inter-scale correlations in the total sample reaching statistical significance (p<0.05), and 17/21 reaching at least a low correlation (0.3).
Why it matters
This study validated English and Spanish caregiver-administered wellbeing scales among Latinos, finding good psychometric properties. The scales are now available for use among US Latinos in research and clinical contexts.
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These findings suggest that HB-CCT via Neurotablet can effectively enhance specific cognitive abilities in PD, supporting the role of digital, home-based interventions as feasible strategies to mitigate cognitive decline.
Why it matters
In this small pilot study of 25 people with Parkinson's disease and mild cognitive impairment, a home-based computerized cognitive training program was linked to improved scores on some memory and attention tests. As a preliminary pilot trial, it does not show whether this training prevents or treats Alzheimer's disease.
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In long-term care residents, ADL scores worsened by a mean of 0.29 points (95%CI = 0.27, 0.31) per 3 months and antihypertensive deprescribing did not impact this worsening (difference between groups -0.04 points every 3 months, 95%CI = -0.15, 0.06).
Why it matters
In long-term care residents, antihypertensive deprescribing did not worsen functional status in those with or without dementia, and in the non-dementia subgroup deprescribed residents showed slightly improved scores. This concerns medication reduction and function, not treating, curing or preventing Alzheimer's disease.
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Fifty-three experts participated (eight completed all rounds).
Why it matters
This modified e-Delphi study established a multicomponent protocol for interprofessional formulation of point-of-care Behaviour Support Plans for hospital patients with dementia and/or delirium. The protocol is ready for feasibility testing in hospitals but has not yet been tested for effectiveness.
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Using three decades of global health data, this study tracked how young-onset dementia (before age 65) has changed since 1990.
Why it matters
Using three decades of global health data, this study found that the raw number of young-onset dementia cases more than tripled, mostly because there are simply more people in the 55-64 age range worldwide, while a person's underlying risk at a given age rose only slightly. Women carried a higher absolute burden than men, though men's rates were rising somewhat faster.
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• SCD patients showed attenuation of sensory (P1, N1, P2) and cognitive (P300, P600, P900) components, with performance-related gains. • MCI patients exhibited neural compensations, reversing the downward trend observed in SCD, which resulted in a non-monotonic pattern of ERPs. • The progression of cognitive decline was linked to electrophysiological discontinuity, suggesting resilience mechanisms in both low and higher order cognitive regions.
Why it matters
In 178 individuals, subjective cognitive decline showed attenuation of sensory and cognitive event-related potential components, while mild cognitive impairment showed compensatory enhancements. These are electrophysiological findings about cognitive decline, not a treatment, cure or prevention.
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Our analysis revealed that 26.40% of the participants had mild cognitive impairment, whereas 48.50% demonstrated low adherence to the MIND diet.
Why it matters
In this cross-sectional study of adults aged 65 or older in Pakistan, lower physical activity was linked to more cognitive impairment and higher MIND diet adherence was linked to less cognitive impairment. Because the study is cross-sectional, it cannot show whether diet or activity causes these differences.
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Despite the differences in partner's dementia status, we found no significant difference in the 5-year cumulative Medicare expenditures between SPWD and SPWND.
Why it matters
This study found no significant difference in 5-year cumulative Medicare expenditures between spouses of people with dementia and spouses of people without dementia. There was a significant difference in the 5th year's total expenditures, driven by inpatient costs, but the overall cumulative difference was not significant.
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ADI was significantly higher in this cohort ( M = 3.84, SD = 2.58) than in the surrounding county ( M = 2.79, SD = 1.88, p = .000).
Why it matters
In this cohort of inpatients with dementia, area deprivation index was higher than in the surrounding county, but there was no significant difference in utilization of swallowing services across deprivation decile groups. The study is about swallowing care and postdischarge support, not about treating, curing, or preventing Alzheimer's disease.
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This global study estimated how much dementia costs the world, combining formal healthcare spending with the value of unpaid family caregiving across 204 countries.
Why it matters
This global study estimated that in 2019, direct healthcare spending on dementia was about $261 billion, but unpaid informal caregiving added even more, about $354 billion, making up more than half of the total cost. By 2050, direct dementia healthcare spending alone is projected to reach $1.6 trillion, nearly one-tenth of all projected global health spending.
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MAs were younger, more likely to be female, less educated, had higher ADI scores, performed worse on trails B (all p < 0.05), and had lower prevalence of APOE4 + when compared to NHWs (p < 0.0001).
Why it matters
In this longitudinal study, living in a more deprived neighborhood was linked to lower cognitive function in Mexican American elders but not in non-Hispanic White elders. It is about social factors and cognition, not about treating, curing or preventing Alzheimer's disease.
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The cluster analysis identified 3 distinct groups: Group 1 was low resource/high distress (n = 215); Group 2 was high resource/low distress (n = 248); and Group 3 was low resource/low distress (n = 353; Figure 1).
Why it matters
Black and Hispanic/Latino older adults fell into three psychosocial groups, and the group with low resources and high distress had poorer cognitive outcomes and more severe Alzheimer's blood biomarker patterns than the other two groups. There were no outcome differences between the high-resource/low-distress and low-resource/low-distress groups.
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A total of 145 342 adults met inclusion criteria; 10.5% had ADRD and were likely to be older, female, and have more comorbid conditions.
Why it matters
This study found that intensive care patients with Alzheimer's disease and related dementias had lower home discharge rates and greater mortality after an ICU stay than patients without these conditions. It does not test any treatment, cure, or prevention, and it highlights the need for care planning for these patients after intensive care.
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The most important predictors of having a diagnosis of ADRD by the start of care OASIS assessment were a prior discharge diagnosis of ADRD among those admitted from an inpatient setting, and frequently exhibiting symptoms of confusion.
Why it matters
This study developed an algorithm using home health assessment data to identify Medicare beneficiaries with Alzheimer's disease and related dementias, with high specificity but poor sensitivity. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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The possible mediating role of cardiovascular disease (CVD) in the relationship between alcohol use disorders (AUD) and the risk of early-onset (<age 65) and late-onset (≥age 65) dementia lacks formal investigation.
Why it matters
This Finnish cohort study found that alcohol use disorders were associated with a substantially increased risk of early-onset dementia and a smaller increased risk of late-onset dementia, with no mediation by cardiovascular disease in men. It identifies alcohol use disorders as a risk factor but does not test any treatment, cure, or prevention for Alzheimer's disease.
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We hypothesize that the experimental group will be more effective in managing caregiver burden and coping strategies and that this will improve the perception of well-being, anxiety, and depression among caregivers.
Why it matters
This is a protocol for a trial of a psychosocial intervention for informal caregivers of people with Alzheimer's disease. No results on whether the intervention helps caregivers are available yet.
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Area deprivation index (ADI), a tool used to capture the multidimensional neighborhood socioeconomic disadvantage across populations, is highly relevant to the field of aging and Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD).
Why it matters
This mini-review describes the Area Deprivation Index as a proxy of resilience that captures multifactorial contributors to dementia risk. It suggests that neighborhood disadvantage can adversely impact cognitive impairment risk but may be a modifiable risk factor.
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After adjusting for multi-morbidity and relocation-related selection bias, we saw that people living in regions with the highest tertile of income (HR = 0.87, p < 0.001), and who had the highest tertile of remaining life expectancy at age 60 (HR = 0.93, p = 0.012) had lower dementia risks.
Why it matters
In Germany, people living in regions with the highest income levels and the highest remaining life expectancy at age 60 had lower dementia risks, with education significant only for men and remaining life expectancy significant only for women. These are regional associations, so the study cannot show that raising income or life expectancy would prevent dementia.
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Older adults living in rural counties had lower cognitive functioning than urban adults.
Why it matters
Older adults in rural counties had lower cognitive functioning than urban adults, and this gap was 40% larger in counties that lost population between 1980 and 2010. These findings point to rural depopulating areas as a target for interventions, but the study did not test any treatment, cure, or prevention.
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Seventy percent of cases are due to Alzheimer's disease (AD) pathology and there is a 10-20 year 'pre-clinical' period before significant cognitive decline occurs.
Why it matters
This scoping review found that AI-based computerized cognitive tests improved discrimination sensitivity by around 4% and specificity by around 3% compared with traditional cognitive tests, and that combining acoustic and linguistic features achieved around 94% accuracy. It is about early detection and does not test any treatment, cure or prevention.
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Individuals living with dementia often have limited capacity to express their care preferences at the final stage of life, and therefore, are at risk of receiving end-of-life care that may not align with their preferences.1 While most people prefer to be at home in their final days of life,2 research has shown that individuals with dementia are less likely to die in a home or community setting compared to those without dementia.3, 4 Studies also suggest that the percentage of individuals with dementia who died in a home or community setting has been increasing over time.5, 6 This study sought to update the literature by examining the association between dementia status and site of death, and by comparing the trends in site of death between decedents with and without dementia using recent national data.
Why it matters
This study found that people with dementia were less likely to die at home or in a community setting and less likely to die in acute care hospitals compared to those without dementia. It does not test any treatment, cure, or prevention for Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Natural history of feeding-tube use in nursing home residents with advanced dementia
- Strategies for the use of Ginkgo biloba extract, EGb 761® , in the treatment and management of mild cognitive impairment in Asia: Expert consensus
- Initiation and persistence of warfarin or aspirin in patients with chronic atrial fibrillation in general practice: do the appropriate patients receive stroke prophylaxis?
- Effects of cognitive training interventions with older adults: a randomized controlled trial
- Association of Prenatal Maternal Psychological Distress With Fetal Brain Growth, Metabolism, and Cortical Maturation
- Hippocampal volume in normal aging and traumatic brain injury
- Psychometric properties of instruments to measure the quality of end-of-life care and dying for long-term care residents with dementia
- Intersectional research on dementia care for post-migrants and ethnic minority groups: a scoping review
- Prevalence and pattern of major neurological disorders in rural Kashmir (India) in 1986
- Factors associated with dementia risk reduction lifestyle in mild cognitive impairment: a cross-sectional study of individuals and their family caregivers