Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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We investigated trends in the incidence of parkinsonism and Parkinson disease (PD) by comparing data from the first 2 subcohorts of the Rotterdam Study, a prospective, population-based cohort study (first subcohort: baseline 1990 with 10 years of follow-up; second subcohort, baseline 2000 with 10 years of follow-up).
Why it matters
This population study compared Parkinson disease incidence between two groups of Rotterdam Study participants followed for up to 10 years. It concerns Parkinson disease trends and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Hypertensive pregnancy disorders are associated with worse performance on tests of processing speed and smaller brain volumes decades later.
Why it matters
This study of 1279 women found that those with a history of hypertensive pregnancy disorders performed worse on measures of processing speed and had signs of brain atrophy decades later. It identifies an association with cardiovascular history but does not test any treatment, cure, or prevention for Alzheimer's disease.
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MCI and dementia were common among survivors from the original ARIC cohort.
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The past century was a period of increasing life expectancy throughout the age range.
Why it matters
This paper notes that recent decades have seen some reductions in dementia prevalence, but that substantially compressing illness would likely require delaying the aging process itself. It describes population trends and does not test any treatment or cure.
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Among older adults, MeDi adherence was associated with less brain atrophy, with an effect similar to 5 years of aging.
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The objective of this study is to examine the discrepancy between single versus age and education corrected cutoff scores in classifying performance on the Montreal Cognitive Assessment (MoCA) in patients with stroke or transient ischemic attack.
Why it matters
This study examined whether using age- and education-adjusted cutoff scores changes how the Montreal Cognitive Assessment classifies stroke patients. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Specialist palliative care is not initiated in almost half of the people for whom it could be beneficial, most frequently because physicians deem regular caregivers to be sufficiently skilled in addressing palliative care needs.
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Sleep quality decreases with aging and thus sleep complaints are prevalent in older adults, particularly for those with cognitive impairment and dementia.
Why it matters
This study of 78 community-dwelling adults aged 55 and over found that perceived sleep quality differed quite a bit from objective sleep measured by actigraphy. It concluded that for older adults the Pittsburgh Sleep Quality Index should not be used as a substitute for actigraphy.
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Pilot studies applying a humanoid robot (NAO), a pet robot (PARO) and a real animal (DOG) in therapy sessions of patients with dementia in a nursing home and a day care center.
Why it matters
This was a pilot study comparing a humanoid robot, a pet robot and a real animal in therapy sessions for patients with advanced dementia. The available text does not report whether these sessions improved cognition or any other outcome.
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The Delphi method has a wide range of potential uses in mental health research.
Why it matters
This article describes the Delphi method, a way of determining expert consensus, and notes it has been used for questions such as the global prevalence of dementia. It is about a research method and does not test any treatment, cure or prevention.
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The preferences of end-of-life issues differed greatly between dementia patients and their caregivers.
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Optimal timing of ACP discussions should be determined by the readiness of the patient and family carer to face end of life.
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The incidence of dementia and cardiovascular disease (CVD) increases with age.
Why it matters
This review argues that cardiovascular burden, including atherosclerosis and arteriosclerosis and risk factors such as smoking, hypertension and diabetes, contributes to cognitive decline and dementia, and that an accumulation of multiple vascular risk factors especially in middle age can substantially increase dementia risk. It suggests that strategies to promote cardiovascular health, especially from early life, might help delay the onset of dementia, but this is a suggested strategy rather than a proven prevention.
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Dementia is a major global health challenge, as its burden on society will increase with population aging.
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These research priorities identify crucial gaps in the existing evidence to address everyday practicalities in the management of the complexities of PD.
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Of 5406 nursing home residents with advanced dementia, 2911 (53.9%) received at least 1 medication with questionable benefit (range, 44.7% in the Mid-Atlantic census region to 65.0% in the West South Central census region).
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50/100
We found that longitudinal measures of cortical atrophy were widely correlated with sleep quality.
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The fall detection system detected 12 out of 15 real-life falls, having a sensitivity of 80.0%, with a false alarm rate of 0.049 alarms per usage hour with the implemented real-time system.
Why it matters
The fall detection system detected 12 out of 15 real-life falls, giving a sensitivity of 80.0%, with a false alarm rate of 0.049 alarms per usage hour that was reduced to 0.025 with minor modification of data analysis. The authors suggest that automatic accelerometric fall detection systems might offer a tool for improving safety among older people.
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Mild cognitive impairment (MCI) as a precursor of dementia with Lewy bodies (DLB) is the focus of recent research, trying to explore the early mechanisms and possible biomarkers of DLB.
Why it matters
In 47 people with mild cognitive impairment followed for three years, all who developed dementia with Lewy bodies showed EEG abnormalities at the start, while most who developed Alzheimer's disease had normal EEGs. This suggests EEG may help predict which type of dementia a person will develop, but it does not address treatment or prevention.
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Women may expect to spend more than a third of their lives after menopause.
Why it matters
This review discusses prevention strategies after menopause, including lifestyle measures, but it does not report a proven way to prevent Alzheimer's disease. It notes that recent Women's Health Initiative publications do not recommend menopause hormonal therapy as a prevention strategy.
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The mindfulness based neuropsychological program showed better cognitive and functional stability, as well as significant improvement in the psychopathological condition of mild to moderate Alzheimer' patients.
Why it matters
In this two-year trial of 127 patients with probable Alzheimer's disease, those receiving a mindfulness-based program remained stable on cognition, function, and behavior, while the control and other experimental groups worsened mildly. The authors conclude the program supported cognitive and functional stability in mild to moderate disease.
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We identified 101 deaths of residents with dementia in 69 nursing homes (58% response rate).
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50/100
Mild cognitive impairment (MCI) marks a transitional stage between healthy aging and dementia, but the understanding of MCI in the general population remains limited.
Why it matters
This study looked at factors linked to mild cognitive impairment, its MRI features, and what happened to people over time in the Rotterdam Study. It describes risk factors and prognosis but does not test any treatment or prevention for dementia.
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Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements.
Why it matters
This review states that type 2 diabetes is associated with dementia and with more slight cognitive decrements, and that vascular damage is a key underlying process in both. It notes no treatment has been established, but that management of vascular risk factors and optimisation of glycaemic control could have therapeutic benefit.
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This study aimed to evaluate the efficacy of a multifactorial 'healthy brain ageing cognitive training program' for Parkinson's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Diabetes mellitus and cognitive impairments
- Interventions to Improve Gait in Older Adults with Cognitive Impairment: A Systematic Review
- Practical Considerations in the Administration of Aducanumab for the Neurologist
- The meaning of cognitive impairment in the elderly
- The relationship between brain structure and neurocognition in schizophrenia: a selective review
- Cognitive assessment across normal aging and subjective cognitive decline using PGIMS and Stroop color-word test: A cross-sectional study
- Assessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties
- Computerized cognitive training for Chinese mild cognitive impairment patients: A neuropsychological and fMRI study
- Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons
- Criteria for enrolling dementia patients in hospice: a replication