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Computerized cognitive training for Chinese mild cognitive impairment patients: A neuropsychological and fMRI study
Li BY, He NY, Qiao Y, Xu HM, Lu YZ, Cui PJ, Ling HW, Yan FH et al.. NeuroImage. Clinical, 2019-01-26
Topic: Risk, prevention and care in population studies
Background Computerized multi-model training has been widely studied for its effect on delaying cognitive decline. In this study, we designed the first Chinese-version computer-based multi-model cognitive training for mild cognitive impairment (MCI) patients. Neuropsychological effects and neural activity changes assessed by functional MRI were both evaluated. Method MCI patients in the training group were asked to take training 3-4 times per week for 6 months. Neuropsychological and resting-state fMRI assessment were performed at baseline and at 6 months. Patients in both groups were continuously followed up for another 12 months and assessed by neuropsychological tests again. Results 78 patients in the training group and 63 patients in the control group accomplished 6-month follow-up. Training group improved 0.23 standard deviation (SD) of mini-mental state examination, while control group had 0.5 SD decline. Addenbrooke's cognitive examination-revised scores in attention (p = 0.002) and memory (p = 0.006), as well as stroop color-word test interference index (p = 0.038) and complex figure test-copy score (p = 0.035) were also in favor of the training effect. Difference between the changes of two groups after training was not statistically significant. The fMRI showed increased regional activity at bilateral temporal poles, insular cortices and hippocampus. However, difference between the changes of two groups after another 12 months was not statistically significant. Conclusions Multi-model cognitive training help MCI patients to gained cognition benefit, especially in memory, attention and executive function. Functional neuroimaging provided consistent neural activation evidence. Nevertheless, after one-year follow up after last training, training effects were not significant. The study provided new evidence of beneficial effect of multi-model cognitive training.
Key findings
- Results 78 patients in the training group and 63 patients in the control group accomplished 6-month follow-up.
- Difference between the changes of two groups after training was not statistically significant.
- However, difference between the changes of two groups after another 12 months was not statistically significant.
- Nevertheless, after one-year follow up after last training, training effects were not significant.
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Study details
- Participants78
- Evidence strengthLow
How this study scored 69/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 40 of the 58 points we could judge it on, which is 69 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (NeuroImage. Clinical) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 11 / 12 | A randomised controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 78 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30708349) |
| Free to read | 2 / 2 | Free to read |
| Points | 40 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 40 of the 58 points we could judge it on is 69 out of 100. |
| Total | 69 / 100 | — |
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APA 7th
Li, B. Y., He, N. Y., Qiao, Y., Xu, H. M., Lu, Y. Z., Cui, P. J., et al. (2019). Computerized cognitive training for Chinese mild cognitive impairment patients: A neuropsychological and fMRI study. NeuroImage. Clinical. https://doi.org/10.1016/j.nicl.2019.101691
Vancouver
Li BY, He NY, Qiao Y, Xu HM, Lu YZ, Cui PJ, et al. Computerized cognitive training for Chinese mild cognitive impairment patients: A neuropsychological and fMRI study. NeuroImage. Clinical. 2019. doi:10.1016/j.nicl.2019.101691. PMID: 30708349.
BibTeX
@article{li2019-30708349,
author = {Li, B. Y. and He, N. Y. and Qiao, Y. and Xu, H. M. and Lu, Y. Z. and Cui, P. J. and Ling, H. W. and Yan, F. H. and others},
title = {{Computerized cognitive training for Chinese mild cognitive impairment patients: A neuropsychological and fMRI study}},
journal = {NeuroImage. Clinical},
year = {2019},
doi = {10.1016/j.nicl.2019.101691},
pmid = {30708349},
url = {https://doi.org/10.1016/j.nicl.2019.101691}
}