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Diabetes mellitus and cognitive impairments
Saedi E, Gheini MR, Faiz F, Arami MA.. World journal of diabetes, 2016-09-01
Topic: Risk, prevention and care in population studies
There is strong evidence that diabetes mellitus increases the risk of cognitive impairment and dementia. Insulin signaling dysregulation and small vessel disease in the base of diabetes may be important contributing factors in Alzheimer's disease and vascular dementia pathogenesis, respectively. Optimal glycemic control in type 1 diabetes and identification of diabetic risk factors and prophylactic approach in type 2 diabetes are very important in the prevention of cognitive complications. In addition, hypoglycemic attacks in children and elderly should be avoided. Anti-diabetic medications especially Insulin may have a role in the management of cognitive dysfunction and dementia but further investigation is needed to validate these findings.
Key findings
- Anti-diabetic medications especially Insulin may have a role in the management of cognitive dysfunction and dementia but further investigation is needed to validate these findings.
Why it matters
This review reports strong evidence that diabetes raises the risk of cognitive impairment and dementia, and that good blood sugar control may help prevent cognitive complications. It notes that anti-diabetic medications, especially insulin, may play a role in managing cognitive dysfunction, but says further investigation is needed to confirm this.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (World journal of diabetes) |
| Journal's citation record | 1 / 4 | World Journal of Diabetes: journal h-index 116 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 269 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 22.4 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 4 / 6 | Cited 16.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 55 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 0 / 4 | Last-listed author Mohammad Ali Arami: h-index 4 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Tehran University of Medical Sciences: institution h-index 810 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27660698) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.4239/wjd.v7.i17.412
- PubMed: 27660698
- Original source →
- Free full text: World Journal of Diabetes →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Saedi, E., Gheini, M. R., Faiz, F., & Arami, M. A. (2016). Diabetes mellitus and cognitive impairments. World journal of diabetes. https://doi.org/10.4239/wjd.v7.i17.412
Vancouver
Saedi E, Gheini MR, Faiz F, Arami MA. Diabetes mellitus and cognitive impairments. World journal of diabetes. 2016. doi:10.4239/wjd.v7.i17.412. PMID: 27660698.
BibTeX
@article{saedi2016-27660698,
author = {Saedi, E. and Gheini, M. R. and Faiz, F. and Arami, M. A.},
title = {{Diabetes mellitus and cognitive impairments}},
journal = {World journal of diabetes},
year = {2016},
doi = {10.4239/wjd.v7.i17.412},
pmid = {27660698},
url = {https://doi.org/10.4239/wjd.v7.i17.412}
}
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