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Trends in the Incidence of Parkinson Disease in the General Population: The Rotterdam Study
Darweesh SK, Koudstaal PJ, Stricker BH, Hofman A, Ikram MA.. American journal of epidemiology, 2016-04-29
Topic: Risk, prevention and care in population studies
We investigated trends in the incidence of parkinsonism and Parkinson disease (PD) by comparing data from the first 2 subcohorts of the Rotterdam Study, a prospective, population-based cohort study (first subcohort: baseline 1990 with 10 years of follow-up; second subcohort, baseline 2000 with 10 years of follow-up). From the baseline years, we observed differences in the second subcohort that were associated with a lower risk of PD for some but not all baseline risk factors. Participants in both subcohorts were followed for a maximum of 10 years and monitored for the onset of parkinsonism, the onset of dementia, or death, until January 1, 2011.
Key findings
- From the baseline years, we observed differences in the second subcohort that were associated with a lower risk of PD for some but not all baseline risk factors.
- Participants in both subcohorts were followed for a maximum of 10 years and monitored for the onset of parkinsonism, the onset of dementia, or death, until January 1, 2011.
- We used Poisson regression models to compare the incidences of parkinsonism, both overall and by cause (PD and secondary causes), and competitive events (incident dementia and death) as well as the mortality of parkinsonism patients in the 2 subcohorts.
- In the 1990 subcohort, there were 182 cases of parkinsonism (84 of which were PD) during 57,052 person-years.
Why it matters
This population study compared Parkinson disease incidence between two groups of Rotterdam Study participants followed for up to 10 years. It concerns Parkinson disease trends and does not test any treatment, cure, or prevention for Alzheimer's disease.
Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 50/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (American journal of epidemiology) |
| Journal's citation record | 3 / 4 | American Journal of Epidemiology: journal h-index 416 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 69 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.8 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 3 / 6 | Cited 5.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 2 / 4 | Cited 22 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27188952) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Darweesh, S. K., Koudstaal, P. J., Stricker, B. H., Hofman, A., & Ikram, M. A. (2016). Trends in the Incidence of Parkinson Disease in the General Population: The Rotterdam Study. American journal of epidemiology. https://doi.org/10.1093/aje/kwv271
Vancouver
Darweesh SK, Koudstaal PJ, Stricker BH, Hofman A, Ikram MA. Trends in the Incidence of Parkinson Disease in the General Population: The Rotterdam Study. American journal of epidemiology. 2016. doi:10.1093/aje/kwv271. PMID: 27188952.
BibTeX
@article{darweesh2016-27188952,
author = {Darweesh, S. K. and Koudstaal, P. J. and Stricker, B. H. and Hofman, A. and Ikram, M. A.},
title = {{Trends in the Incidence of Parkinson Disease in the General Population: The Rotterdam Study}},
journal = {American journal of epidemiology},
year = {2016},
doi = {10.1093/aje/kwv271},
pmid = {27188952},
url = {https://doi.org/10.1093/aje/kwv271}
}
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