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Determinants, MRI correlates, and prognosis of mild cognitive impairment: the Rotterdam Study
de Bruijn RF, Akoudad S, Cremers LG, Hofman A, Niessen WJ, van der Lugt A, Koudstaal PJ, Vernooij MW et al.. Journal of Alzheimer's disease : JAD, 2014-01-01
Topic: Risk, prevention and care in population studies
Mild cognitive impairment (MCI) marks a transitional stage between healthy aging and dementia, but the understanding of MCI in the general population remains limited. We investigated determinants, MRI-correlates, and prognosis of MCI within the population-based Rotterdam Study. Firstly, we studied age, APOE-ε4 carriership, waist circumference, hypertension, diabetes mellitus, total and HDL-cholesterol levels, smoking, and stroke as potential determinants of MCI.
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APA 7th
de Bruijn, R. F., Akoudad, S., Cremers, L. G., Hofman, A., Niessen, W. J., van der Lugt, A., et al. (2014). Determinants, MRI correlates, and prognosis of mild cognitive impairment: the Rotterdam Study. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-132558
Vancouver
de Bruijn RF, Akoudad S, Cremers LG, Hofman A, Niessen WJ, van der Lugt A, et al. Determinants, MRI correlates, and prognosis of mild cognitive impairment: the Rotterdam Study. Journal of Alzheimer's disease : JAD. 2014. doi:10.3233/jad-132558. PMID: 24825566.
BibTeX
@article{debruijn2014-24825566,
author = {de Bruijn, R. F. and Akoudad, S. and Cremers, L. G. and Hofman, A. and Niessen, W. J. and van der Lugt, A. and Koudstaal, P. J. and Vernooij, M. W. and others},
title = {{Determinants, MRI correlates, and prognosis of mild cognitive impairment: the Rotterdam Study}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2014},
doi = {10.3233/jad-132558},
pmid = {24825566},
url = {https://doi.org/10.3233/jad-132558}
}
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Key findings
- We investigated determinants, MRI-correlates, and prognosis of MCI within the population-based Rotterdam Study.
- Firstly, we studied age, APOE-ε4 carriership, waist circumference, hypertension, diabetes mellitus, total and HDL-cholesterol levels, smoking, and stroke as potential determinants of MCI.
- Determinants were assessed cross-sectionally at baseline (2002-2005) and up to 7 years prior to baseline (1997-2001).
- Secondly, we compared volumetric, microstructural, and focal MRI-correlates in persons with and without MCI.
Why it matters
This study looked at factors linked to mild cognitive impairment, its MRI features, and what happened to people over time in the Rotterdam Study. It describes risk factors and prognosis but does not test any treatment or prevention for dementia.
Study details
- Participants4,198
- Effect sizeHR 4.03; HR 1.54
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | 2 / 4 | Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 4,198 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 78 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.6 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 3 / 6 | Cited 4.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 1 / 4 | Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24825566) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
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