Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Atrial cardiomyopathy, characterized by abnormalities in atrial structure and function, is associated with increased risk of adverse cardiovascular and neurocognitive outcomes, independent of atrial fibrillation.
Why it matters
Abnormal P wave parameters on a standard ECG have been linked in population studies to higher risks of dementia, along with atrial fibrillation, ischemic stroke, and sudden cardiac death. More work is needed to standardize their measurement before they can be used in routine clinical practice.
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Validation of the safety and efficacy of ECT in patients with advanced AD with refractory agitation and aggression is necessary.
Why it matters
This paper describes the methods for a trial testing electroconvulsive therapy for agitation and aggression in people with moderate to severe Alzheimer's disease, using a simulated control group. It reports no results, so it does not yet show an effect on treating, curing or preventing the disease.
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Air pollution may cause inflammatory and oxidative stress damage to the brain, leading to neurodegenerative disease.
Why it matters
This study examined associations between air pollution and three types of incident dementia, and whether APOE-ε4 genotype modifies these associations. It looks at a possible risk factor but does not test any treatment, cure, or prevention.
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Stroke is a leading cause of disability, dementia and death worldwide.
Why it matters
This review describes the high and growing burden of stroke in Africa, including its role as a cause of dementia, with strokes often occurring in younger adults. It is about stroke epidemiology and prevention on the continent, not about treating, curing or preventing Alzheimer's disease.
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SiN hearing impairment is independently associated with incident dementia, providing further evidence for hearing impairment as a potential modifiable dementia risk factor.
Why it matters
This large study found that people aged 60 and over with poor speech-in-noise hearing had a higher risk of developing dementia over about 11 years. It suggests hearing impairment may be a modifiable risk factor for dementia, though it does not show that treating hearing loss prevents dementia.
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Traumatic brain injury (TBI), particularly of greater severity (i.e., moderate to severe), has been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for specific dementia subtypes being more variable.
Why it matters
This review describes traumatic brain injury, especially moderate to severe, as a risk factor for all-cause dementia and Parkinson's disease, and discusses processes that may contribute to neurodegeneration. It does not provide a treatment, cure or prevention for Alzheimer's disease.
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The multi-sectoral collaborative care model proposed in this study integrated resources from several departments, effectively improved the quality of life of patients and their caregivers, and provided a way of care services for patients with Alzheimer Disease.
Why it matters
In this 6-month randomized trial of 150 Alzheimer's disease patients in a nursing home, a multi-sectoral comprehensive intervention improved patients' communication, housework handling, self-care, and quality of life, as well as caregivers' quality of life and caring ability. The intervention addresses care and quality of life rather than curing or preventing the disease.
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MRI studies have provided valuable insights into the structure and function of neural networks, particularly in health and in classical neurodegenerative conditions such as Alzheimer disease.
Why it matters
This review discusses how multiple sclerosis pathology affects brain networks as seen on MRI and how these changes relate to clinical impairment. It is about multiple sclerosis, not Alzheimer's disease, so it does not directly inform Alzheimer's treatment, cure, or prevention.
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56/100
Individuals with neuropsychiatric, cardiovascular, and sensory impairment/cancer patterns are at increased risk for dementia and APOE ε4, and inflammation may further increase the risk.
Why it matters
This study found that older adults with certain patterns of multiple chronic diseases had higher dementia risk, and that inflammation and the APOE ε4 gene may further increase risk. It suggests identifying high-risk groups might allow tailored prevention, but it does not show that any intervention prevents dementia.
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Alzheimer's Disease is a complex, multifactorial, and comorbid condition.
Why it matters
Using machine learning on self-reported information from a large Spanish aging study, subjective cognitive decline stood out as the most important feature for future conversion to mild cognitive impairment. This identifies risk factors for prediction and does not treat, cure or prevent Alzheimer's disease.
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Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities.
Why it matters
Researchers from the Latin American and Caribbean Consortium on Dementia argue that the region's dementia work is held back by "heterogeneity, diversity, political instability, and socioeconomic disparities," and propose a shared "Knowledge to Action Framework" to tackle them together. The paper reviews strategies across epidemiology, genetics, biomarkers, clinical trials and non-drug interventions, and names regional complications such as "genetic isolates" and "admixture in populations." It is an agenda, not a study: it reports no new data and does not show that any treatment or plan prevents or slows dementia.
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56/100
Relative to white caregivers, blacks more often provided in excess of 40 hr of care per week (54.3% vs 38.6%) and more often cared for an older adult with dementia (27.1% vs 20.7%) who was living below the federal poverty line (31.7% vs 11.9%) or was Medicaid-eligible (42.2% vs 11.8%).
Why it matters
This study found differences in caregiving experiences between Black and white caregivers of older Americans, including that Black caregivers more often cared for someone with dementia. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Epidemiological studies identify midlife hearing loss as an independent risk factor for dementia, estimated to account for 9% of cases.
Why it matters
This paper evaluates several possible brain mechanisms that could explain why midlife hearing loss is linked to dementia, including effects on the auditory pathway, cognitive reserve, and the medial temporal lobe. It suggests that whether hearing interventions reduce dementia risk depends on which mechanism is at work, and calls for further research to clarify this.
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56/100
Our recruitment rate demonstrates the feasibility of cohort participants to wear two devices that measure sedentary time and physical activity.
Why it matters
This study describes physical activity and sitting patterns in older adults using wearable devices. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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We categorized CVH on the basis of the American Heart Association Ideal CVH Index and genetic risk through a genetic risk score (GRS) of common genetic variants and the APOE ε4 genotype in 1,211 Framingham Heart Study (FHS) offspring cohort participants.
Why it matters
In 1,211 Framingham Heart Study offspring cohort participants, this study examined how ideal cardiovascular health and genetic risk jointly relate to incident all-cause dementia over up to 10 years. Genetic risk was assessed using a genetic risk score and APOE ε4 genotype, and the analysis adjusted for age, sex, and education.
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Type 2 diabetes and cognitive dysfunction are highly prevalent disorders worldwide.
Why it matters
This paper states that type 2 diabetes is associated with an increased risk of dementia but that awareness of this link among clinicians is poor and few guidelines exist. It calls for better screening and management rather than reporting a proven way to prevent or treat dementia.
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Prior studies have analyzed the burden of cognitive impairment, but often use potentially biased prevalence-based methods or measure only years lived with impairment, without estimating other relevant metrics.
Why it matters
This analysis estimated that about two out of three Americans age 50 and older experience some cognitive impairment, with lifetime dementia risk of 37% for women and 24% for men. It describes the burden and timing of cognitive impairment, including differences by race, ethnicity and education, but does not test any treatment or prevention.
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56/100
Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of clinical features commonly known as Down syndrome (DS).
Why it matters
This review describes Down syndrome as caused by an extra copy of chromosome 21 and discusses how mouse models are used to study which triplicated genes contribute to its features. It does not report any treatment, cure, or prevention for Alzheimer's disease.
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The CDR® plus NACC FTLD was able to detect early symptoms in the mildly impaired participants who were rated as CDR® sum of boxes (CDR®-SB) = 0.
Why it matters
This study tested a revised clinical rating scale for detecting early symptoms in mild frontotemporal lobar degeneration. It concerns a different disease and a diagnostic tool, not treating, curing, or preventing Alzheimer's disease.
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Alzheimer's disease (AD) and dementia are a global public health priority, and prevention has been highlighted as a pivotal component in managing the dementia epidemic.
Why it matters
The FINGER trial showed that a multidomain lifestyle-based intervention targeting vascular and lifestyle-related risk factors can preserve cognitive functioning and reduce the risk of cognitive decline in older adults at increased risk of dementia. The World-Wide FINGERS network is now testing similar interventions in other populations.
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56/100
Baseline NPS, categorized for MBI domain and duration, have prognostic utility in addition to brain morphology measures for predicting diagnosis change using ML.
Why it matters
In 102 people with normal cognition and 239 with mild cognitive impairment, a machine learning model using mild behavioral impairment score and left hippocampal volume classified participants as remaining normal or developing cognitive impairment with 84.4% accuracy, while a three-class model achieved 58.8% accuracy. The study concerns prediction of follow-up diagnosis, not treating, curing, or preventing Alzheimer's disease.
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Cerebrovascular diseases are well established causes of cognitive impairment.
Why it matters
This systematic review covers how brain imaging is used to define and diagnose vascular cognitive impairment and dementia, thinking problems caused by disease of the brain's blood vessels. It presents MRI as the leading technique, especially with standardised protocols, and notes that functional MRI and PET may help tell different forms of dementia apart.
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Across all domains, 14 constructs influenced development and implementation.
Why it matters
This process evaluation reports that 14 constructs influenced development and implementation of a rural primary health care intervention for dementia. It is about implementing a care intervention, not about treating, curing, or preventing Alzheimer's disease.
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In each cohort, achieving just 10-21.4 min/day moderate-to-vigorous PA related to better executive function ( P P = .02).
Why it matters
This cross-sectional study found that moderate-to-vigorous physical activity was associated with better executive function in middle-aged and older adults. It does not prove that physical activity prevents or treats Alzheimer's disease, only that an association was found.
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In older adults, hearing loss is independently associated with an increased rate of cognitive decline, and has been identified to be a modifiable risk factor for dementia.
Why it matters
This ongoing longitudinal study is testing whether cochlear implants affect cognitive function in older adults with severe hearing loss, since hearing loss is a modifiable risk factor for dementia. It reports baseline and 18-month results and does not yet show whether treating hearing loss prevents or cures Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Dementia Prevalence in a Rural Region of South Africa: A Cross-Sectional Community Study
- Comparing phenotypic features between Parkinson’s disease dementia and dementia with Lewy bodies
- Interactions Between Age, Sex, Menopause, and Brain Structure at Midlife: A UK Biobank Study
- Individualized clinical management of patients at risk for Alzheimer's dementia
- MoCA, ACE-R, and MMSE versus the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards Neuropsychological Battery after TIA and stroke
- Post-stroke cognitive impairment and dementia research in Southeast Asia: A scoping review
- Cognitive interventions for healthy older adults: A systematic meta-review
- Key informants’ perceptions of telehealth palliative care for people living with dementia in nursing homes
- Understanding emergency department staff needs and perceptions in the provision of palliative care
- Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011-2013