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Interactions Between Age, Sex, Menopause, and Brain Structure at Midlife: A UK Biobank Study
Than S, Moran C, Beare R, Vincent AJ, Collyer TA, Wang W, Callisaya ML, Thomson R et al.. The Journal of clinical endocrinology and metabolism, 2021-01-01
Topic: Risk, prevention and care in population studies
Objectives Age and female sex are risk factors for dementia, and menopause is associated with cognitive dysfunction. Previous work largely considered the effects of sex and menopause as being independent of age. We studied whether age interacts with sex or menopause in explaining imaging biomarkers of dementia during midlife.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Than, S., Moran, C., Beare, R., Vincent, A. J., Collyer, T. A., Wang, W., et al. (2021). Interactions Between Age, Sex, Menopause, and Brain Structure at Midlife: A UK Biobank Study. The Journal of clinical endocrinology and metabolism. https://doi.org/10.1210/clinem/dgaa847
Vancouver
Than S, Moran C, Beare R, Vincent AJ, Collyer TA, Wang W, et al. Interactions Between Age, Sex, Menopause, and Brain Structure at Midlife: A UK Biobank Study. The Journal of clinical endocrinology and metabolism. 2021. doi:10.1210/clinem/dgaa847. PMID: 33205159.
BibTeX
@article{than2021-33205159,
author = {Than, S. and Moran, C. and Beare, R. and Vincent, A. J. and Collyer, T. A. and Wang, W. and Callisaya, M. L. and Thomson, R. and others},
title = {{Interactions Between Age, Sex, Menopause, and Brain Structure at Midlife: A UK Biobank Study}},
journal = {The Journal of clinical endocrinology and metabolism},
year = {2021},
doi = {10.1210/clinem/dgaa847},
pmid = {33205159},
url = {https://doi.org/10.1210/clinem/dgaa847}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Previous work largely considered the effects of sex and menopause as being independent of age.
- We studied whether age interacts with sex or menopause in explaining imaging biomarkers of dementia during midlife.
- Methods In this cross-sectional study of UK Biobank participants with brain magnetic resonance imaging (MRI), we explored the interaction of age with sex or menopausal status in explaining total brain volume (TBV), gray matter volume (GMV), white matter volume (WMV), white matter hyperintensity volume (WMHV), regional cortical volume , and subcortical volume.
- Results Data were available for 1827 postmenopausal women, 230 pre/perimenopausal women and 2165 men (median age 63.3 years).
Why it matters
This cross-sectional UK Biobank study examined whether age interacts with sex or menopause in explaining imaging biomarkers of dementia during midlife. It is cross-sectional, so it cannot show that any treatment or intervention would prevent dementia.
Study details
- Study designcross-sectional
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journal of clinical endocrinology and metabolism) |
| Journal's citation record | 3 / 4 | The Journal of Clinical Endocrinology & Metabolism: journal h-index 490 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 63 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.0 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 3 / 6 | Cited 3.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 2 / 4 | Cited 40 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Velandai K. Srikanth: h-index 72 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Monash University: institution h-index 1,146 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33205159) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
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