Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
-
Survival analyses indicated that subjects with the lowest EF scores were more likely to fall sooner and more likely to experience multiple falls during the 66 months of follow-up (p Conclusions/significance These findings demonstrate that among community-living older adults, the risk of future falls was predicted by performance on EF and attention tests conducted 5 years earlier.
Why it matters
In this five-year study of older adults without dementia, lower executive function and attention scores and greater dual-task gait variability were associated with higher future fall risk. It links cognition to falls but does not test any treatment, cure or prevention for Alzheimer's disease.
-
The evidence is not conclusive as to whether some symptoms are more important than others.
Why it matters
This systematic review of 35 studies found no consistent system for categorizing behavioural and psychological symptoms of dementia, though depression, aggression, and sleep disturbances were the most frequently identified patient symptoms affecting caregiver burden or depression. The authors suggest that identifying specific symptoms may help develop effective interventions for caregivers.
-
We conclude that smaller PFAv may contribute to slower gait through slower information processing.
-
Trajectories of Aβ42 level in CSF, FDG uptake, and hippocampal volume vary across different cognitive stages.
-
60/100
These findings underscore the complexity of the hospice patient population and highlight a potential need to risk adjust the per diem hospice reimbursement rates to account for increased resource requirements for hospices serving patients with higher comorbidity burden.
-
60/100
The hippocampus is involved at the onset of the neuropathological pathways leading to Alzheimer's disease (AD).
Why it matters
An automated analysis of hippocampus shape predicted which people with mild cognitive impairment would develop dementia within a year, with about 80% accuracy. This is a prediction tool for identifying who may convert, not a treatment or cure.
-
Having multiple CMBs or concomitant CMBs and retinopathy is associated with a profile of vascular cognitive impairment.
Why it matters
This cross-sectional study found that multiple cerebral microbleeds and retinopathy were associated with lower cognitive scores and higher odds of vascular dementia in older people. It is about associations with vascular damage, not about treating, curing or preventing Alzheimer's disease.
-
When prospectively validated at the bedside and used as a continuous measure, the ability of the ADEPT score to identify nursing home residents with advanced dementia at high risk of death within 6 months was modest, albeit better than hospice eligibility guidelines.
-
60/100
Sensitivity to psychotropic medications presents a therapeutic challenge when treating neuropsychiatric symptoms in patients with dementia with Lewy bodies (DLB).
Why it matters
In this trial of patients with dementia with Lewy bodies and Alzheimer's disease, most patients with DLB tolerated citalopram or risperidone poorly and did not seem to benefit from either medication. It offers no treatment advance for the underlying disease.
-
When planning liaison services, the setting and demographic features of the population need to be taken into account.
-
Longitudinal changes in motor function may be useful in the early detection of dementia during preclinical stages, when the utility of disease-modifying therapies would be greatest.
Why it matters
In this cohort, motor decline as indexed by gait speed accelerated up to 12 years before mild cognitive impairment. Longitudinal changes in motor function may be useful in the early detection of dementia during preclinical stages, when the utility of disease-modifying therapies would be greatest.
-
60/100
Limiting the clinical use of definite anticholinergics may reduce the incidence of cognitive impairment among African Americans.
Why it matters
In a 6-year observational study of 1,652 African American adults over 70 who started with normal cognition, each additional *definite* anticholinergic medicine taken at baseline was linked to higher odds of developing cognitive impairment (OR 1.46, 95% CI 1.07–1.99), after adjusting for age, gender, education and baseline cognition. Medicines with only *possible* anticholinergic activity, used by 53% of participants, showed no such link (OR 0.96). This shows an association, not proof of cause. The study did not test stopping any drug, so medication changes should be discussed with a prescriber.
-
60/100
Dementia, depression and anxiety disorders are the most common psychiatric disorders among older adults in LTC.
Why it matters
This review found that dementia and other psychiatric disorders are common among older adults in long-term care homes, with dementia having a median prevalence of 58%. It describes how common these conditions are but does not test any treatment, cure, or prevention.
-
Study objective Delirium's adverse effect on long-term mortality in older hospitalized patients is well documented, whereas its effect in older emergency department (ED) patients remains unclear.
Why it matters
This prospective cohort study examined whether delirium in the emergency department independently predicted death within 6 months in patients aged 65 and older. It is an observational study of prognosis, not a test of any treatment or prevention for Alzheimer's disease.
-
Different biomarkers for Alzheimer disease provide different information from one another that is likely to be complementary.
Why it matters
This study found that PET and cerebrospinal fluid measures of amyloid beta agreed with each other but were not related to cognitive impairment, while FDG-PET was modestly related to other biomarkers and better related to cognition. It shows that different Alzheimer's biomarkers provide different information, but does not offer a treatment or cure.
-
We found no significant correlation between CSF biomarkers and cognitive scores in any of the 3 clinical groups individually.
Why it matters
In 399 subjects, CSF biomarkers showed no significant correlation with cognitive scores in any clinical group, while MRI scores correlated with cognition in mild cognitive impairment and Alzheimer disease. The authors conclude MRI reflects clinically defined disease stage better than the CSF biomarkers tested, so this is about diagnosis, not treatment.
-
The association between the pathological features of Alzheimer's disease and dementia is stronger in younger old persons than in older old persons.
Why it matters
This brain study found that the link between Alzheimer's-type pathological changes and dementia weakened with increasing age. It does not test any treatment, cure, or prevention.
-
Higher adherence to the MeDi is associated with a trend for reduced risk of developing MCI and with reduced risk of MCI conversion to AD.
Why it matters
In this community study, higher adherence to a Mediterranean diet was associated with lower risk of developing mild cognitive impairment, with the highest adherence group showing 28% less risk. This is an observational study and cannot prove that the diet prevents cognitive decline.
-
The presence of burst suppression, which was unexpectedly high in this medical intensive care unit population, was an independent predictor of increased risk of death at 6 months.
-
When assessed by simple questions, SMC appear to be present in the minority of those with mild cognitive impairment and dementia.
Why it matters
This meta-analysis found that subjective memory complaints were present in 42.8% of those with dementia and 38.2% of those with mild cognitive impairment, compared with 17.4% in healthy elderly controls. It concluded that subjective memory complaints have poor value for ruling in a diagnosis of dementia but good value for ruling out a diagnosis.
-
Odor identification deficits occur in Alzheimer's disease (AD) and mild cognitive impairment (MCI), and predict clinical conversion from MCI to AD.
-
We investigated in a population-based cohort study the association of global and lobar brain tissue volumes with specific cognitive domains and risk of dementia.
-
60/100
Participants were most likely to develop depression, apathy, or anxiety, and least likely to develop elation or disinhibition.
Why it matters
This study found that neuropsychiatric symptoms were nearly universal in people with dementia, with depression, apathy, and anxiety most common over five years. It describes the course of these symptoms but does not test any treatment, cure, or prevention.
-
In this study, Triflusal therapy was associated with a significant lower rate of conversion to dementia that is likely to be clinically relevant.
Why it matters
In this trial of 257 patients with amnestic mild cognitive impairment, triflusal did not reach significance on the primary cognitive outcome, though there was a lower risk of progression to Alzheimer's dementia. Recruitment stopped early, so the results are limited and do not establish triflusal as a treatment or prevention.
-
60/100
Psychosocial intervention makes a vital contribution to dementia care.
Why it matters
This European consensus recommended 22 measures across nine domains to make psychosocial intervention studies in dementia care more comparable. It is about how to measure the effects of care and support, not about treating, curing or preventing the disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Doing as much as I can do: the meaning of activity for people with dementia
- Caregivers' reasons for nursing home placement: clues for improving discussions with families prior to the transition
- The effect of integrated emotion-oriented care versus usual care on elderly persons with dementia in the nursing home and on nursing assistants: a randomized clinical trial
- Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial
- Prevalence of dementia in adults with and without Down syndrome
- Quantum AI for psychiatric diagnosis: enhancing dementia classification with quantum machine learning
- Palliative care documentation in gastrointestinal bleeding hospitalizations: national trends and associated care patterns
- Cerebral small vessel disease: A review
- Hippocampal and Amygdala Gray Matter Loss in Elderly Controls with Subtle Cognitive Decline
- Mapping racial and ethnic healthcare disparities for persons living with dementia: A scoping review