Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Late-life heart diseases increase the subsequent risk of dementia and AD.
Why it matters
In this population-based study with over 25 years of follow-up, atrial fibrillation in late life was an independent risk factor for dementia and Alzheimer's disease, while heart diseases diagnosed at midlife did not increase the risk. It identifies a risk factor and does not report a treatment, cure, or prevention.
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Compared with non-dementia patients, hospitalised dementia patients have higher rates of potentially preventable complications that might be responsive to nursing interventions.
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Diabetes was associated with an increased risk of MCI in elderly persons.
Why it matters
This study found that people with type 2 diabetes were more likely to develop mild cognitive impairment, including the amnestic subtype most linked to Alzheimer's disease. It does not show that treating diabetes prevents dementia, only that diabetes is associated with higher risk.
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Age and higher baseline BMI, independent of gender, and other confounding factors, are risk factors for cognitive decline.
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Preliminary results suggest that hospice enrolment might be influenced by the facility or region of this particular country.
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The purpose of this study was to examine the beneficial effects of a new cognitive intervention program designed for the care and prevention of dementia, namely Learning Therapy.
Why it matters
Cognitive training using reading and arithmetic tasks was reported to maintain and improve cognitive function in people with Alzheimer-type dementia and in healthy seniors. The paper describes this as a transfer effect, but it is a cognitive intervention, not a cure or prevention.
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Residents dying with advanced dementia who received SNF care in the last 90 days of life had fewer aggressive treatments and lower odds of hospital death if they also received hospice care at any point during that time.
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Despite a similar level of dementia severity, patterns of DTI changes in AD and DLB differed significantly.
Why it matters
This imaging study found that patterns of white matter tract changes differed between people with dementia with Lewy bodies and those with Alzheimer's disease. It is a comparison of brain scan patterns between two types of dementia and does not test any treatment, cure, or prevention.
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Hippocampal sclerosis (HS) is a common and often asymmetric neuropathological finding among elderly persons who experience progressive memory loss, but its cause is unknown and it is rarely diagnosed during life.
Why it matters
In an autopsy sample, hippocampal sclerosis was found in about a quarter of cases and was often accompanied by other pathologies, with most cases showing TDP-43 inclusions. Because it can occur unilaterally, its prevalence may be underestimated, but this is a descriptive autopsy study with no treatment implications.
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Demographic and clinical factors impact PD survival.
Why it matters
This study looked at survival in people with Parkinson disease and found that dementia was linked to a greater likelihood of death. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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We believe this information important when counseling elderly patients regarding the risks of mortality and PJI after TKA and risk-adjusting publicly reported TKA patient outcomes.
Why it matters
This study of Medicare patients having knee replacement found that dementia was among the conditions linked to higher risk of death within 90 days after surgery. It is about surgical risk in people who already have dementia, not about treating, curing or preventing Alzheimer's disease.
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The NutriAlz program had no effect on functional decline in Alzheimer disease patients living at home over one year, but reduced the risk for malnutrition, as recommendations concerning diet and exercise were provided.
Why it matters
This cluster randomized trial of 946 home-living Alzheimer patients tested a health and nutrition program against usual care, with the one-year assessment completed for 65.4% of the intervention group and 72.9% of the control group. It addresses nutrition and functional level in dementia care, not treating, curing, or preventing Alzheimer's disease.
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It is recommended that the IOH definition be applied when taking continuous noninvasive orthostatic BP measurements in older people.
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55/100
The ongoing development of robotics on the one hand and, on the other hand, the foreseen relative growth in number of elderly individuals suffering from dementia, raises the question of which contribution robotics could have to rationalize and maintain, or even improve the quality of care.
Why it matters
This systematic review assessed published effects of socially assistive robots in elderly care, including people with dementia. It found mostly positive effects but calls for further effectiveness research, and it is about care assistance, not treating, curing or preventing Alzheimer's disease.
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MCI diagnosis frequencies are substantively affected by the stringency of the criteria, but the relative rankings of MCI subtype diagnoses are fairly consistent regardless of the stringency of the criteria.
Why it matters
This study showed that how strictly mild cognitive impairment is defined changes how many people are diagnosed and which factors, including APOE genotype, relate to the diagnosis. It highlights that diagnostic criteria matter for research and clinical practice, but it does not test any treatment or prevention.
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A CDR rating of 0.5 (uncertain/very mild dementia) was obtained by 27.6% of participants, whereas 1.2% had CDR ≥ 1 (mild or moderate dementia).
Why it matters
In this population-based study of 1,982 participants, 27.6% received a Clinical Dementia Rating of 0.5 and 1.2% had a rating of 1 or higher, showing that how mild cognitive impairment criteria are operationalized determines how many people are classified. The authors note that prospective follow-up is needed to determine progression to dementia, so no treatment or prevention is addressed.
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Our data suggest that cardiovascular risk factors may modulate the clinical expression of CADASIL.
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We examined the association of type 2 diabetes mellitus to function in different cognitive systems in older black and white persons.
Why it matters
In this cohort, type 2 diabetes was associated with impairment in semantic memory in both black and white older adults. Because diabetes was twice as common in black participants, the burden of diabetes on cognition was higher in black than white persons.
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In the past 10 years, there has been a virtual explosion in the literature concerning the construct of mild cognitive impairment.
Why it matters
A review of research progress on mild cognitive impairment, described as the earliest clinical features of disorders such as Alzheimer disease and other dementias. It also notes challenges that remain.
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In recent years, a series of publications have demonstrated a potentially important role for magnetic resonance imaging in the pre-mortem diagnosis of sporadic Creutzfeldt-Jakob disease.
Why it matters
This paper concerns updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease and the role of magnetic resonance imaging in diagnosing it before death. It provides no information on treating, curing or preventing Alzheimer's disease.
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Rivastigmine therapy for PDD is associated with significant tradeoffs in efficacy and adverse effects.
Why it matters
This review of a 541-person randomized trial found that rivastigmine improved scores on two cognitive scales in people with Parkinson disease dementia, but the difference was not significant when judged by clinically meaningful benefit. The authors also note that boosting cholinergic function could plausibly worsen parkinsonism.
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Greater fish and omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake may reduce dementia risk; however, previous studies have reported conflicting results, which were largely based on short-term follow-up.
Why it matters
This study examined whether dietary intake of fish and omega-3 fatty acids is related to long-term dementia risk in a population-based cohort. It is an observational study of a possible dietary factor and does not test any treatment, cure, or prevention.
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HCPs of NH patients with advanced dementia can most commonly expect to encounter medical decisions relating to feeding problems, infections, and pain.
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Future research should examine both current and pre-caregiving relationship quality.
Why it matters
This review found that caregiving can affect the quality of the relationship between the caregiver and the person with dementia. It also found that the quality of that relationship appears to affect the caregiver's well-being.
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Our study estimates the sensitivity and specificity of Medicare claims to identify clinically-diagnosed dementia, and documents how errors in dementia assessment affect dementia cost estimates.
Why it matters
This study found that Medicare claims had 0.85 sensitivity and 0.89 specificity for dementia compared with clinical assessments, and using claims overestimated the increase in Medicare costs due to dementia. It is about using claims data for research and cost estimates, not about treating, curing, or preventing Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia
- Discovering Hidden Links: Harnessing Similarity Network Fusion to Reveal Common Clusters in Healthy Aging, Mild Cognitive Impairment, and Dementia
- Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial
- Street Network Models and Measures for Every U.S. City, County, Urbanized Area, Census Tract, and Zillow-Defined Neighborhood
- Visual rating and volumetry of the medial temporal lobe on magnetic resonance imaging in dementia: a comparative study
- Taking Care of the Dyad: Frequency of Caregiver Assessment Among Veterans with Dementia
- What do relatives value most in end-of-life care for people with dementia?
- Health of Bi+ Dementia Caregivers: Moderation Effects of Minority and Caregiving Stress
- Home Health Quality among Hospitalized Older Adults with Alzheimer's Disease and Related Dementia: Association with Race/Ethnicity and Dual Eligibility before and during the COVID Pandemic
- Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI