Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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These findings are consistent with reports that care homes can provide care akin to hospice for the very old and support an approach of supporting residents to stay in their care home or own home if possible.
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Prevalence estimates across MBI domains were affective dysregulation (77.8%); impulse control (64.4%); decreased motivation (51.7%); social inappropriateness (27.8%); and abnormal perception or thought content (8.7%).
Why it matters
This study found that mild behavioral impairment was common in memory clinic patients without dementia and was linked to greater caregiver burden. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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53/100
BPSD are universally present, bear correlates with dementia type and severity, and cause significant caregiver distress.
Why it matters
Nearly all 107 dementia patients in this clinic sample had at least one behavioral or psychological symptom, and these symptoms were linked to more caregiver distress. This describes the burden of dementia symptoms and caregiving, not any treatment, cure, or prevention.
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Goal To examine dementia characteristics, age at onset and associated co-morbidities in persons with Down syndrome.
Why it matters
This 20-year follow-up of 77 people with Down syndrome aged 35 and older examined dementia characteristics, age at onset and associated co-morbidities. It describes dementia in this group and offers no treatment, cure or prevention.
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Approximately one-third of the Medicare beneficiaries who died in 2011 had four or more transitions within their last 6 months of life.
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The past 3 decades have been characterized by an exponential growth in knowledge and advances in the clinical treatment of atrial fibrillation (AF).
Why it matters
This review discusses atrial fibrillation and its link to stroke and thromboembolism, but notes that the role of anticoagulation for preventing dementia attributed to AF is less established. It does not provide evidence that treating AF prevents dementia.
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Hypertension is a highly prevalent condition which has been established as a risk factor for cardiovascular and cerebrovascular disease.
Why it matters
This review concludes it is still unclear whether high blood pressure is a treatable risk factor for cognitive decline and dementia, though high midlife blood pressure is consistently linked to later decline. It describes possible mechanisms such as blood vessel remodeling and reduced clearance of proteins like beta-amyloid, but reports no proven treatment or cure.
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The independent and combined effects of physical and cognitive domains of frailty in predicting the development of mild cognitive impairment (MCI) or dementia are not firmly established.
Why it matters
This study examined whether physical frailty and cognitive impairment together predict later neurocognitive disorder in older Chinese adults. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Whilst nursing home managers recognise the potential benefits of advance care planning, barriers and challenges create a reluctance to facilitate.
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We conclude that eight-week MBI for older adults are feasible, but results on cognitive improvement are inconclusive due a limited number of studies, small sample sizes, and a high risk of bias.
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The Petersen/Winblad criteria classified 34% of participants as having MCI while the Jak/Bondi criteria classified 24% as MCI.
Why it matters
In 1,203 Framingham Heart Study participants, a stricter way of diagnosing mild cognitive impairment (Jak/Bondi: two low test scores in a thinking domain instead of one) labelled 24% of people with MCI, compared with 34% under the usual Petersen/Winblad rules. Even so, the authors found a "similar" link to later dementia (hazard ratio 3.30 vs 2.64). Over about 9.7 years only 5% of all participants developed dementia, and the authors call for more work on alternatives to conventional MCI criteria rather than declaring a new standard.
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53/100
Total burden of comorbid neuropathologic abnormalities, rather than any single lesion type, was the most relevant determinant of cognitive impairment in both cohorts, often despite clinical diagnosis of only AD.
Why it matters
This autopsy study found that having more than one type of brain abnormality at once was common and was strongly linked to cognitive impairment. It suggests that the total burden of these combined abnormalities, rather than any single one, matters most for thinking problems in late life.
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53/100
This review provides the reader with the up-to-date evidence-based basis for prescribing exercise as medicine in the treatment of 26 different diseases: psychiatric diseases (depression, anxiety, stress, schizophrenia); neurological diseases (dementia, Parkinson's disease, multiple sclerosis); metabolic diseases (obesity, hyperlipidemia, metabolic syndrome, polycystic ovarian syndrome, type 2 diabetes, type 1 diabetes); cardiovascular diseases (hypertension, coronary heart disease, heart failure, cerebral apoplexy, and claudication intermittent); pulmonary diseases (chronic obstructive pulmonary disease, asthma, cystic fibrosis); musculo-skeletal disorders (osteoarthritis, osteoporosis, back pain, rheumatoid arthritis); and cancer.
Why it matters
This review provides evidence-based guidance for prescribing exercise as therapy across 26 chronic diseases including dementia. It discusses exercise as a therapy, not a cure or proven prevention for Alzheimer's disease.
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Delirium affected a fifth of acute medical admissions and a third of those aged ≥75 years, and was associated with increased mortality, institutionalisation and dependency, but not with increased risk of re-admission on follow-up.
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People continue to receive disease-focused therapies at the end of life rather than therapies exclusively for palliation of symptoms, suggesting that treatments may vary according to the person's primary diagnosis.
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The brain is an inherently dynamic system, and executive cognition requires dynamically reconfiguring, highly evolving networks of brain regions that interact in complex and transient communication patterns.
Why it matters
This brain imaging study in healthy people found that a working-memory task causes frontal brain networks to reconfigure, and this flexibility predicted performance on memory and thinking tests. It helps understand how these networks work but does not test any treatment, cure, or prevention for Alzheimer's disease.
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An estimated 47 million people worldwide are living with dementia in 2015, and this number is projected to triple by 2050.
Why it matters
In a 2015 summary prepared at the World Dementia Council's request, the Alzheimer's Association concluded that regular physical activity and managing diabetes, obesity, smoking and high blood pressure reduce the risk of cognitive decline and may reduce the risk of dementia. It judged that a healthy diet and lifelong learning or cognitive training may also reduce the risk of cognitive decline, but made no dementia claim for those two. These are the Association's population-level judgements with no risk estimates attached, not results of a new trial, and they do not single out Alzheimer's disease.
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A cross-sectional study of geriatric patients was performed to provide a comprehensive description of the prevalence and clinical characteristics of chronic itch affecting Hispanic geriatric subjects in Mexico.
Why it matters
This study described the prevalence and characteristics of chronic itch in a Hispanic geriatric population in Mexico. It does not address Alzheimer's disease treatment, cure or prevention.
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Baseline data of 423 PD patients and 196 HCs yielded no between-group differences in demographic characteristics.
Why it matters
In early, untreated Parkinson's disease, about 10% of patients met criteria for cognitive impairment, and some neuropsychiatric symptoms were more common than in healthy controls. This describes the frequency of these problems but does not address treating or preventing Alzheimer's disease.
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Caregivers play a major role in the care of patients with dementia and are themselves at higher risk of disease.
Why it matters
This cross-sectional study looked at which factors are linked to caregiver burden among people with Alzheimer's disease or related disorders attending a memory clinic. It focuses on caregivers and functional autonomy and behavioural symptoms, not on treating, curing or preventing Alzheimer's disease itself.
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The purpose of this retrospective, cross-sectional study was to determine the prevalence of advance care planning (ACP) among older people presenting to an Emergency Department (ED) from the community or a residential aged care facility.
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Most NH residents who use statins at the time of progression to advanced dementia continue use in follow-up.
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The rigorous methodology of the study will hopefully move forward the scientific evaluation of traditional Chinese medicine in treatment of VaD.
Why it matters
This is a design paper for a trial testing a traditional Chinese medicine in vascular dementia, a different condition from Alzheimer's disease. No results are reported, so it shows nothing about treating, curing or preventing Alzheimer's disease.
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Our objective was to determine whether the consumption of green tea, coffee, or black tea influences the incidence of dementia and mild cognitive impairment (MCI) in older people.
Why it matters
This study found that daily green tea consumption was associated with reduced risk of cognitive decline, but no association was found for coffee or black tea. It is observational and does not show that green tea prevents or treats Alzheimer's disease.
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Data were used from the first wave of The Irish Longitudinal Study on Ageing (TILDA), a prospective cohort study that includes a comprehensive health assessment.
Why it matters
This study provided normative values for cognitive and physical function tests from a large representative sample of people in Ireland aged 50 and older. It establishes reference values for testing, not a treatment, cure or prevention for Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Essential oils and functional herbs for healthy aging
- Assessment scales in dementia
- Dementia care and COVID-19 pandemic: a necessary digital revolution
- The impact of moxibustion on brain function in vascular dementia: a neuroimaging study involving amplitude of low-frequency fluctuations and functional connectivity
- Can multidisciplinary guidelines improve the palliation of symptoms in the terminal phase of dementia?
- Naming in semantic dementia--what matters?
- Catastrophic health expenditure among Chinese adults living alone with cognitive impairment: findings from the CHARLS
- Deficits of knowledge versus executive control in semantic cognition: insights from cued naming
- Supporting Individuals With Cognitive Impairment and Family Members in Rural Communities: Protocol for a Mixed Methods Digital Health Study
- A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia