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58/100

✓ Peer-reviewed alzhub usefulness score 58 out of 100. Mild cognitive impairment

Topic: Brain proteins, microglia and lab models

Background The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia. Methods Three multicenter cohorts of cognitively healthy elderly, mild cognitive impairment (MCI), and AD participants with standardized clinical assessments and structural neuroimaging measures were used. Twenty-six candidate proteins were quantified in 1148 subjects using multiplex (xMAP) assays. Results Sixteen proteins correlated with disease severity and cognitive decline. Strongest associations were in the MCI group with a panel of 10 proteins predicting progression to AD (accuracy 87%, sensitivity 85%, and specificity 88%). Conclusions We have identified 10 plasma proteins strongly associated with disease severity and disease progression. Such markers may be useful for patient selection for clinical trials and assessment of patients with predisease subjective memory complaints.

Key findings

Background The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia.
Results Sixteen proteins correlated with disease severity and cognitive decline.
Conclusions We have identified 10 plasma proteins strongly associated with disease severity and disease progression.

Why it matters

In this study of 1,148 subjects, a panel of 10 plasma proteins predicted progression from mild cognitive impairment to Alzheimer's disease with 87% accuracy. The authors say such markers may be useful for patient selection for clinical trials and assessment of patients with predisease subjective memory complaints.

Study details

Participants1,148
Evidence strengthLow

How this study scored 58/100

Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2014 — within 20 year(s) of the newest study here
Sample size	3 / 4	1,148 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 198 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	14.1 citations a year over 14 year(s) since 2014
Impact for its field and year	5 / 6	Cited 21.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 9 other studies in this library
Still being cited	1 / 4	Cited 12 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Simon Lovestone: h-index 118 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Oxford: institution h-index 2,205 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 16 institution(s) in 10 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 25012867)
Free to read	2 / 2	Free to read
Total	58 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Hye, A., Riddoch-Contreras, J., Baird, A. L., Ashton, N. J., Bazenet, C., Leung, R., et al. (2014). Plasma proteins predict conversion to dementia from prodromal disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1016/j.jalz.2014.05.1749

Vancouver

Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, et al. Plasma proteins predict conversion to dementia from prodromal disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2014. doi:10.1016/j.jalz.2014.05.1749. PMID: 25012867.

BibTeX

@article{hye2014-25012867,
  author  = {Hye, A. and Riddoch-Contreras, J. and Baird, A. L. and Ashton, N. J. and Bazenet, C. and Leung, R. and Westman, E. and others},
  title   = {{Plasma proteins predict conversion to dementia from prodromal disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2014},
  doi     = {10.1016/j.jalz.2014.05.1749},
  pmid    = {25012867},
  url     = {https://doi.org/10.1016/j.jalz.2014.05.1749}
}

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