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Evidence that aging and amyloid promote microglial cell senescence
Flanary BE, Sammons NW, Nguyen C, Walker D, Streit WJ.. Rejuvenation research, 2007-03-01
Topic: Brain proteins, microglia and lab models
Advanced age and presence of intracerebral amyloid deposits are known to be major risk factors for development of neurodegeneration in Alzheimer's disease (AD), and both have been associated with microglial activation. However, the specific role of activated microglia in AD pathogenesis remains unresolved. Here we report that microglial cells exhibit significant telomere shortening and reduction of telomerase activity with normal aging in rats, and that in humans there is a tendency toward telomere shortening with presence of dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Flanary, B. E., Sammons, N. W., Nguyen, C., Walker, D., & Streit, W. J. (2007). Evidence that aging and amyloid promote microglial cell senescence. Rejuvenation research. https://doi.org/10.1089/rej.2006.9096
Vancouver
Flanary BE, Sammons NW, Nguyen C, Walker D, Streit WJ. Evidence that aging and amyloid promote microglial cell senescence. Rejuvenation research. 2007. doi:10.1089/rej.2006.9096. PMID: 17378753.
BibTeX
@article{flanary2007-17378753,
author = {Flanary, B. E. and Sammons, N. W. and Nguyen, C. and Walker, D. and Streit, W. J.},
title = {{Evidence that aging and amyloid promote microglial cell senescence}},
journal = {Rejuvenation research},
year = {2007},
doi = {10.1089/rej.2006.9096},
pmid = {17378753},
url = {https://doi.org/10.1089/rej.2006.9096}
}
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Key findings
- However, the specific role of activated microglia in AD pathogenesis remains unresolved.
- Here we report that microglial cells exhibit significant telomere shortening and reduction of telomerase activity with normal aging in rats, and that in humans there is a tendency toward telomere shortening with presence of dementia.
- Human brains containing high amyloid loads demonstrate a significantly higher degree of microglial dystrophy than nondemented, amyloid-free control subjects.
- Collectively, these findings show that microglial cell senescence associated with telomere shortening and normal aging is exacerbated by the presence of amyloid.
Why it matters
This study reports telomere shortening and reduced telomerase activity in microglia with normal aging in rats, and a tendency toward telomere shortening with dementia in humans, along with more microglial dystrophy in brains with high amyloid loads. It states that the specific role of activated microglia in Alzheimer's disease remains unresolved and offers no treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 42/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Rejuvenation research) |
| Journal's citation record | 1 / 4 | Rejuvenation Research: journal h-index 85 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 273 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 13.0 citations a year over 21 year(s) since 2007 |
| Impact for its field and year | 3 / 6 | Cited 4.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 9 other studies in this library |
| Still being cited | 2 / 4 | Cited 43 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Wolfgang J. Streit: h-index 68 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Florida: institution h-index 1,303 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17378753) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 42 / 100 | — |
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