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Biomarkers for early detection of Alzheimer pathology
Clark CM, Davatzikos C, Borthakur A, Newberg A, Leight S, Lee VM, Trojanowski JQ.. Neuro-Signals, 2007-12-05
Topic: Amyloid, tau and blood-test diagnosis
The increasing prevalence of Alzheimer's disease and the devastating consequences of late-life dementia motivates the drive to develop diagnostic biomarkers to reliably identify the pathology associated with this disorder. Strategies to accomplish this include the detection of altered levels of tau and amyloid in cerebrospinal fluid, the use of structural MRI to identify disease-specific patterns of regional atrophy and MRI T(1)rho to detect disease-related macromolecular protein aggregation, and the direct imaging of amyloid deposits using positron emission tomography and single photon emission computerized tomography. Success will facilitate the ability to reliably diagnose Alzheimer's disease while the symptoms of brain failure are mild and may provide objective measures of disease-modifying treatment efficacy.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Clark, C. M., Davatzikos, C., Borthakur, A., Newberg, A., Leight, S., Lee, V. M., et al. (2008). Biomarkers for early detection of Alzheimer pathology. Neuro-Signals. https://doi.org/10.1159/000109754
Vancouver
Clark CM, Davatzikos C, Borthakur A, Newberg A, Leight S, Lee VM, et al. Biomarkers for early detection of Alzheimer pathology. Neuro-Signals. 2008. doi:10.1159/000109754. PMID: 18097155.
BibTeX
@article{clark2008-18097155,
author = {Clark, C. M. and Davatzikos, C. and Borthakur, A. and Newberg, A. and Leight, S. and Lee, V. M. and Trojanowski, J. Q.},
title = {{Biomarkers for early detection of Alzheimer pathology}},
journal = {Neuro-Signals},
year = {2008},
doi = {10.1159/000109754},
pmid = {18097155},
url = {https://doi.org/10.1159/000109754}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- The increasing prevalence of Alzheimer's disease and the devastating consequences of late-life dementia motivates the drive to develop diagnostic biomarkers to reliably identify the pathology associated with this disorder.
Why it matters
This paper reviews strategies for developing biomarkers to detect Alzheimer's pathology early, including cerebrospinal fluid tau and amyloid, structural MRI, MRI T(1)rho, and amyloid PET or SPECT imaging. It discusses diagnosis and possible measures of treatment efficacy, but it does not itself test a treatment, cure, or prevention.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuro-Signals) |
| Journal's citation record | 1 / 4 | Neurosignals: journal h-index 83 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 94 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.7 citations a year over 20 year(s) since 2008 |
| Impact for its field and year | 3 / 6 | Cited 5.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 12 other studies in this library |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author John Q. Trojanowski: h-index 255 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Pennsylvania: institution h-index 1,859 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18097155) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 41 / 100 | — |
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