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Effect of deep brain stimulation on patients with Parkinson’s disease with mild cognitive impairment
Sunny H Vansdadia, Pooja Dhupati, Priya Ramaiah, Sara S. Dhanani, Robert Wagner Bina. BMJ Neurology Open, 2026-01-01
Topic: Risk, prevention and care in population studies
Eight studies comprising 984 patients met inclusion criteria. Six studies identified PD-MCI as a potential risk factor for developing PDD post-DBS, though only two demonstrated statistically significant cognitive decline post-DBS. Five studies found no differences in outcomes post-DBS, between patients with PD-MCI and PD without cognitive impairment. DBS does not appear to significantly worsen cognitive decline in patients with PD-MCI beyond the expected disease progression. However, certain cognitive domains, particularly visuospatial impairments, may increase the risk of adverse outcomes. Standardised cognitive screening is necessary for optimal patient selection for future research to refine clinical guidelines for DBS eligibility.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Vansdadia, S. H., Dhupati, P., Ramaiah, P., Dhanani, S. S., & Bina, R. W. (2026). Effect of deep brain stimulation on patients with Parkinson’s disease with mild cognitive impairment. BMJ Neurology Open. https://doi.org/10.1136/bmjno-2025-001442
Vancouver
Vansdadia SH, Dhupati P, Ramaiah P, Dhanani SS, Bina RW. Effect of deep brain stimulation on patients with Parkinson’s disease with mild cognitive impairment. BMJ Neurology Open. 2026. doi:10.1136/bmjno-2025-001442. PMID: 41877733.
BibTeX
@article{vansdadia2026-41877733,
author = {Vansdadia, Sunny H and Dhupati, Pooja and Ramaiah, Priya and Dhanani, Sara S. and Bina, Robert Wagner},
title = {{Effect of deep brain stimulation on patients with Parkinson’s disease with mild cognitive impairment}},
journal = {BMJ Neurology Open},
year = {2026},
doi = {10.1136/bmjno-2025-001442},
pmid = {41877733},
url = {https://doi.org/10.1136/bmjno-2025-001442}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Eight studies comprising 984 patients met inclusion criteria.
- Six studies identified PD-MCI as a potential risk factor for developing PDD post-DBS, though only two demonstrated statistically significant cognitive decline post-DBS.
- Five studies found no differences in outcomes post-DBS, between patients with PD-MCI and PD without cognitive impairment.
- DBS does not appear to significantly worsen cognitive decline in patients with PD-MCI beyond the expected disease progression.
- However, certain cognitive domains, particularly visuospatial impairments, may increase the risk of adverse outcomes.
Why it matters
This review of eight studies with 984 patients found that deep brain stimulation does not appear to significantly worsen cognitive decline in Parkinson's disease patients with mild cognitive impairment beyond expected disease progression. It concerns a Parkinson's treatment and cognitive outcomes, not treating, curing or preventing Alzheimer's disease.
Study details
- Study designsystematic review
- Participants984
- Evidence strengthHigh
How this study scored 54/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (BMJ Neurology Open) |
| Journal's citation record | 0 / 4 | BMJ Neurology Open: journal h-index 23 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 2 / 4 | 984 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | A review of other studies — randomization is not credited here |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.5 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 3 / 6 | Cited 4.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Robert Wagner Bina: h-index 12 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Banner Sun Health Research Institute: institution h-index 285 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41877733) |
| Free to read | 2 / 2 | Free to read |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1136/bmjno-2025-001442
- PubMed: 41877733
- Original source →
- Free full text: BMJ Neurology Open →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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