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Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome
Jason K Russell, Zinayida Schlachetzki, Beau M. Ances, Michael S. Rafii, Beau M. Ances, Howard F Andrews, Karen L. Bell, Rasmus M. Birn et al.. JAMA Neurology, 2026-01-12
Topic: Amyloid, tau and blood-test diagnosis
This cross-sectional study examines data for participants in the Alzheimer Biomarker Consortium–Down Syndrome study to gauge the concordance of clinical and biological Alzheimer disease staging.
Key findings
- This cross-sectional study examines data for participants in the Alzheimer Biomarker Consortium–Down Syndrome study to gauge the concordance of clinical and biological Alzheimer disease staging.
Why it matters
This study examines how well clinical staging matches biological staging of Alzheimer's disease in people with Down syndrome. It does not test a treatment or prevention, but aims to improve how the disease is classified in this high-risk group.
Study details
- Study designcross-sectional
- Evidence strengthLow
How this study scored 46/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 44 of the 96 points we could judge it on, which is 46 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA Neurology) |
| Journal's citation record | 2 / 4 | JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 4 / 6 | Cited 9.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author Fan Zhang holds only 1 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41525055) |
| Free to read | 2 / 2 | Free to read |
| Points | 44 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 44 of the 96 points we could judge it on is 46 out of 100. |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamaneurol.2025.5261
- PubMed: 41525055
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Russell, J. K., Schlachetzki, Z., Ances, B. M., Rafii, M. S., Andrews, H. F., Bell, K. L., et al. (2026). Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2025.5261
Vancouver
Russell JK, Schlachetzki Z, Ances BM, Rafii MS, Andrews HF, Bell KL, et al. Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome. JAMA Neurology. 2026. doi:10.1001/jamaneurol.2025.5261. PMID: 41525055.
BibTeX
@article{russell2026-41525055,
author = {Russell, Jason K and Schlachetzki, Zinayida and Ances, Beau M. and Rafii, Michael S. and Andrews, Howard F and Bell, Karen L. and Birn, Rasmus M. and others},
title = {{Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome}},
journal = {JAMA Neurology},
year = {2026},
doi = {10.1001/jamaneurol.2025.5261},
pmid = {41525055},
url = {https://doi.org/10.1001/jamaneurol.2025.5261}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
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