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Motoric cognitive risk syndrome: Multicenter incidence study
Verghese J, Ayers E, Barzilai N, Bennett DA, Buchman AS, Holtzer R, Katz MJ, Lipton RB et al.. Neurology, 2014-10-31
Topic: Brain imaging, connectivity and assessment
Objective To report incidence and risk factors for motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints. Methods We examined incidence rates of MCR in 3,128 adults aged 60 years and older, MCR- and dementia-free at baseline, participating in 4 US-based cohort studies. Hazard ratios (HRs) with 95% confidence intervals (CIs) for the association of modifiable risk factors with risk of MCR were computed using Cox models. Results Over a median follow-up time of 3.2 years, 823 of the 3,128 participants met MCR criteria. The overall age- and sex-adjusted incidence of MCR was 65.2/1,000 person-years (95% CI: 53.3-77.1), and ranged from 50.8/1,000 person-years to 79.6/1,000 person-years in the individual cohorts. MCR incidence was higher with older age but there were no sex differences. In the pooled sample adjusted for age, sex, education, and cohort source, strokes (HR 1.42, 95% CI: 1.14-1.77), Parkinson disease (HR 2.52, 95% CI: 1.68-3.76), depressive symptoms (HR 1.65, 95% CI: 1.28-2.13), sedentariness (HR 1.76, 95% CI: 1.44-2.17), and obesity (HR 1.39, 95% CI: 1.17-1.65) predicted risk of incident MCR. Conclusions The incidence of MCR is high in older adults. Identification of modifiable risk factors for MCR will improve identification of high-risk individuals and help develop interventions to prevent cognitive decline in aging.
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APA 7th
Verghese, J., Ayers, E., Barzilai, N., Bennett, D. A., Buchman, A. S., Holtzer, R., et al. (2014). Motoric cognitive risk syndrome: Multicenter incidence study. Neurology. https://doi.org/10.1212/wnl.0000000000001084
Vancouver
Verghese J, Ayers E, Barzilai N, Bennett DA, Buchman AS, Holtzer R, et al. Motoric cognitive risk syndrome: Multicenter incidence study. Neurology. 2014. doi:10.1212/wnl.0000000000001084. PMID: 25361778.
BibTeX
@article{verghese2014-25361778,
author = {Verghese, J. and Ayers, E. and Barzilai, N. and Bennett, D. A. and Buchman, A. S. and Holtzer, R. and Katz, M. J. and Lipton, R. B. and others},
title = {{Motoric cognitive risk syndrome: Multicenter incidence study}},
journal = {Neurology},
year = {2014},
doi = {10.1212/wnl.0000000000001084},
pmid = {25361778},
url = {https://doi.org/10.1212/wnl.0000000000001084}
}
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Key findings
- Results Over a median follow-up time of 3.2 years, 823 of the 3,128 participants met MCR criteria.
- The overall age- and sex-adjusted incidence of MCR was 65.2/1,000 person-years (95% CI: 53.3-77.1), and ranged from 50.8/1,000 person-years to 79.6/1,000 person-years in the individual cohorts.
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Study details
- Study designcohort study
- Participants3,128
- Effect sizeHR 1.42; HR 2.52; HR 1.65
- Evidence strengthModerate
How this study scored 70/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record and institution's track record, so those were left out: it earned 43 of the 61 points we could judge it on, which is 70 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 3,128 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 2 / 3 | PubMed indexes it as a multicentre study |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25361778) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 43 / 61 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 43 of the 61 points we could judge it on is 70 out of 100. |
| Total | 70 / 100 | — |
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