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49/100

✓ Peer-reviewed alzhub usefulness score 49 out of 100. Cognitive tests and assessment

Topic: Risk, prevention and care in population studies

After adjusting for potential confounders, multivariable logistic regression models revealed that the prevalence of dementia was significantly higher in individuals with chronic pain than in those without. Furthermore, a longer pain duration (>24 months) was associated with a significantly increased risk of dementia compared to a shorter duration (3-24 months) (OR = 2.60, p 24 months group. Chronic pain duration is significantly associated with dementia, with depression playing a differential mediating role across chronic pain durations.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Tan, Y., Chen, S., Tian, Q., Duan, J., Liu, X., Yu, W., et al. (2026). A dual-pathway model of depression's mediation between chronic pain and dementia. Experimental Gerontology. https://doi.org/10.1016/j.exger.2026.113068

Vancouver

Tan Y, Chen S, Tian Q, Duan J, Liu X, Yu W, et al. A dual-pathway model of depression's mediation between chronic pain and dementia. Experimental Gerontology. 2026. doi:10.1016/j.exger.2026.113068. PMID: 41679614.

BibTeX

@article{tan2026-41679614,
  author  = {Tan, Ying and Chen, Shiyu and Tian, Qi and Duan, Jingxi and Liu, Xintong and Yu, Weihua and Lu, Yang},
  title   = {{A dual-pathway model of depression's mediation between chronic pain and dementia}},
  journal = {Experimental Gerontology},
  year    = {2026},
  doi     = {10.1016/j.exger.2026.113068},
  pmid    = {41679614},
  url     = {https://doi.org/10.1016/j.exger.2026.113068}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

After adjusting for potential confounders, multivariable logistic regression models revealed that the prevalence of dementia was significantly higher in individuals with chronic pain than in those without.
Furthermore, a longer pain duration (>24 months) was associated with a significantly increased risk of dementia compared to a shorter duration (3-24 months) (OR = 2.60, p 24 months group.
Chronic pain duration is significantly associated with dementia, with depression playing a differential mediating role across chronic pain durations.

Why it matters

This study found that dementia prevalence was significantly higher in people with chronic pain than in those without, and longer pain duration was associated with increased dementia risk. Depression played a differential mediating role across chronic pain durations.

Study details

Study designcross-sectional
Participants1,096
Effect sizeOR = 2.60
Evidence strengthLow

How this study scored 49/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 47 of the 96 points we could judge it on, which is 49 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Experimental Gerontology)
Journal's citation record	2 / 4	Experimental Gerontology: journal h-index 195 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	3 / 4	1,096 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.5 citations a year over 2 year(s) since 2026
Impact for its field and year	3 / 6	Cited 4.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	OpenAlex's profile for last-listed author Yang Lu holds only 6 work(s), too few to judge a track record — left out of this score
Institution's track record	0 / 3	Chongqing Medical University: institution h-index 359 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41679614)
Free to read	2 / 2	Free to read
Points	47 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 47 of the 96 points we could judge it on is 49 out of 100.
Total	49 / 100	—

What each of these 20 components measures, and what this score is not →

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