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Dementia Burden and Modifiable Risk Factors in Type 2 Diabetes: Population Based, Prospective Cohort Study
Chuanrui Sun, Tianyu Wu, Congcong Yu, Sijue Yang, Huijie Yang, Zhou Zhang, Yan Bi. Diabetes Obesity and Metabolism, 2026-03-26
Topic: Risk, prevention and care in population studies
T2D was associated with a higher risk and earlier onset of dementia, especially in cases with T2D diagnosed at ages 30-54 years. Globally, an estimated 9.57 million (95% CI, 5.59-10.39) dementia cases in 2021 were attributable to T2D, accounting for 16.85% (9.64%-18.33%) of the global dementia burden, and this proportion is expected to exceed 25% by 2050. This increasing risk of dementia in T2D was significantly associated with multidomain modifiable risk factors, and optimizing all these factors to favourable levels could potentially prevent 47.1% of dementia cases in T2D. To facilitate the clinical practice of risk prevention, a concise set of T2D Cognitive Health Essential 10 with evidence-based intervention targets was further developed, which was associated with no significant excess dementia risk in T2D. T2D-attributable dementia is a time-evolving, escalating, and highly modifiable global health challenge. Integrating multidomain interventions into standard diabetes care, particularly for individuals with younger-onset T2D, and adapting strategies to local contexts may substantially reduce the dementia burden.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Sun, C., Wu, T., Yu, C., Yang, S., Yang, H., Zhang, Z., et al. (2026). Dementia Burden and Modifiable Risk Factors in Type 2 Diabetes: Population Based, Prospective Cohort Study. Diabetes Obesity and Metabolism. https://doi.org/10.1111/dom.70712
Vancouver
Sun C, Wu T, Yu C, Yang S, Yang H, Zhang Z, et al. Dementia Burden and Modifiable Risk Factors in Type 2 Diabetes: Population Based, Prospective Cohort Study. Diabetes Obesity and Metabolism. 2026. doi:10.1111/dom.70712. PMID: 41889158.
BibTeX
@article{sun2026-41889158,
author = {Sun, Chuanrui and Wu, Tianyu and Yu, Congcong and Yang, Sijue and Yang, Huijie and Zhang, Zhou and Bi, Yan},
title = {{Dementia Burden and Modifiable Risk Factors in Type 2 Diabetes: Population Based, Prospective Cohort Study}},
journal = {Diabetes Obesity and Metabolism},
year = {2026},
doi = {10.1111/dom.70712},
pmid = {41889158},
url = {https://doi.org/10.1111/dom.70712}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- T2D was associated with a higher risk and earlier onset of dementia, especially in cases with T2D diagnosed at ages 30-54 years.
- Globally, an estimated 9.57 million (95% CI, 5.59-10.39) dementia cases in 2021 were attributable to T2D, accounting for 16.85% (9.64%-18.33%) of the global dementia burden, and this proportion is expected to exceed 25% by 2050.
- This increasing risk of dementia in T2D was significantly associated with multidomain modifiable risk factors, and optimizing all these factors to favourable levels could potentially prevent 47.1% of dementia cases in T2D.
- To facilitate the clinical practice of risk prevention, a concise set of T2D Cognitive Health Essential 10 with evidence-based intervention targets was further developed, which was associated with no significant excess dementia risk in T2D.
- T2D-attributable dementia is a time-evolving, escalating, and highly modifiable global health challenge.
Why it matters
This prospective cohort study found that type 2 diabetes was linked to higher and earlier dementia risk, especially when diagnosed at ages 30-54, and estimated that optimizing modifiable risk factors could potentially prevent many cases. It supports integrating multidomain interventions into diabetes care, but the prevention estimate is modelled rather than proven in a trial.
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Study details
- Effect sizeor 16.85; 9.64%; 18.33%
- Evidence strengthModerate
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Diabetes Obesity and Metabolism) |
| Journal's citation record | 2 / 4 | Diabetes Obesity and Metabolism: journal h-index 186 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.5 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 3 / 6 | Cited 4.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Yan Bi: h-index 33 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Nanjing University: institution h-index 850 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41889158) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 39 / 100 | — |
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