Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,901–26,925 of 27,380 studies, newest first · page 1077 of 1096.
January 1992 7
-
1992-01-01
Speech monitoring skills in Alzheimer's disease, Parkinson's disease, and normal aging
40/100 ✓ Peer-reviewed Digital health tools Brain and language
Key finding: We examined the abilities of 15 patients with dementia of the Alzheimer type (DAT), 22 patients with Parkinson's Disease (PD), and 141 healthy subjects (ranging in age from 30 to 79 years) to detect and correct their own speech errors.
Full summary, score breakdown and related studies → Original source
-
1992-01-01
Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study
55/100 ✓ Peer-reviewed How common it is Neurology
Key finding: The prevalence of dementia was 30.5/1,000 for men and 48.2/1,000 for women and increased with advancing age. +4 more findings
Full summary, score breakdown and related studies → Original source
-
1992-01-01
Incontinence and troublesome behaviors predict institutionalization in dementia
46/100 ✓ Peer-reviewed Caregiving Journal of geriatric psychiatry and neurology
Key finding: After follow-up of 19 +/- 12 months, 51 patients had been institutionalized. +4 more findings
Full summary, score breakdown and related studies → Original source
-
1992-01-01
Melas: an original case and clinical criteria for diagnosis
47/100 ✓ Peer-reviewed Getting a diagnosis Neuromuscular disorders : NMD
Key finding: The syndrome should be suspected by the following three invariant criteria: (1) stroke-like episode before age 40 yr; (2) encephalopathy characterized by seizures, dementia, or both; and (3) lactic acidosis, ragged-red fibers (RRF), or both. +4 more findings
Full summary, score breakdown and related studies → Original source
-
1992-01-01
MR-based hippocampal volumetry in the diagnosis of Alzheimer's disease
58/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: The volumetric measurements of both the normalized ATL and HF were significantly smaller (p less than 0.001) in DAT patients (N = 20) than in controls (N = 22), but the HF volumes provided much better separation between the two groups. +2 more findings
Full summary, score breakdown and related studies → Original source
-
1992-01-01
Aluminium and the pathogenesis of Alzheimer's disease: a summary of evidence
69/100 ✓ Peer-reviewed Treatments Ciba Foundation symposium
Key finding: The principal outcome was that the mean slope for performance of the skills of daily living for the group without treatment was -1.72% maximum score/month, compared to -0.87% maximum score/month for the group treated with desferrioxamine (P = 0.038).
Full summary, score breakdown and related studies → Original source
-
1992-01-01
Clinical studies with oxiracetam in patients with dementia of Alzheimer type and multi-infarct dementia of mild to moderate degree
67/100 ✓ Peer-reviewed Treatments Neuropsychobiology
Key finding: At the end of therapy, statistical analysis evidenced significant improvements in the group receiving oxiracetam in respect to the placebo group on Mini Mental State Examination, Auditory Continuous Performance Test, Rey's 15 Words Test, Block Tapping Test, Mattis Word Fluency, Luria Alternating Series and Instrumental Activities of Daily Living. +2 more findings
Full summary, score breakdown and related studies → Original source
December 1991 4
-
1991-12-01
Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Microglial cells and astrocytes are closely associated with nearly all compact deposits of the amyloid beta-protein found in the senile plaques characteristic of Alzheimer's disease and trisomy 21. +3 more findings
Full summary, score breakdown and related studies → Original source
-
1991-12-01
Circadian rhythm disorders in sleep-waking and body temperature in elderly patients with dementia and their treatment
47/100 ✓ Peer-reviewed Clinical safety Sleep
Key finding: These observations indicate that behavioral disorders such as delirium, agitation or wandering in patients with severe dementia might be closely related to disrupted biological rhythms of sleep-waking and the autonomic system (body temperature).
Full summary, score breakdown and related studies → Original source
-
1991-12-01
Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease
43/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: Lysosomes, which contain a wide variety of proteases (cathepsins) and other acid hydrolases, are major sites for the turnover of membrane proteins and other cell constituents. +3 more findings
Full summary, score breakdown and related studies → Original source
-
1991-12-01
Prevalence of Alzheimer's disease and other dementias in an elderly urban population: relationship with age, sex, and education
50/100 ✓ Peer-reviewed How common it is Neurology
Key finding: In contrast to previously reported data, we found the same proportion of AD and vascular dementia in the different age strata, and no sex differences regarding the prevalence of different dementia types.
Full summary, score breakdown and related studies → Original source
November 1991 6
-
1991-11-01
The Neuropathologic Basis of Different Clinical Subgroups of Parkinson's Disease
43/100 ✓ Peer-reviewed Risk factors Journal of Neuropathology & Experimental Neurology
Key finding: The AR-type (compared with the T-type) showed higher neuronal loss of LC, SNL, SNM, and more severe gliosis, extraneuronal melanin deposits, and neuroaxonal dystrophy in substantia nigra. +2 more findings
Full summary, score breakdown and related studies → Original source
-
1991-11-01
A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities
36/100 ✓ Peer-reviewed Drug development The Biochemical journal
Key finding: Our results further support the notion that PHF contain abnormally phosphorylated tau in an aggregated state, and indicate that these abnormally phosphorylated tau forms are composed of several tau isoforms and that the full length of the tau molecule is present in these polypeptides.
Full summary, score breakdown and related studies → Original source
-
1991-11-01
Hippocampal neuron number in schizophrenia. A stereological study
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry
Key finding: Total hippocampal volume was reduced in the schizophrenic sample, more pronounced on the left side, but mean differences were not significant. +1 more finding
Full summary, score breakdown and related studies → Original source
-
1991-11-01
Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites
44/100 ✓ Peer-reviewed Risk genes beyond APOE Brain research
Key finding: Using immunofluorescence, laser confocal microscopy and immunoelectron microscopy with simultaneous detection of APP and synaptophysin, we now report a preferential localization of APP at synaptic sites of human and rat brain and at neuromuscular junctions. +2 more findings
Full summary, score breakdown and related studies → Original source
-
1991-11-01
The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2
39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America
Key finding: These findings indicate that although KPI- APP mRNA is abundant in brain, little corresponding protein is present.
Full summary, score breakdown and related studies → Original source
-
1991-11-01
Development and validation of a model for estimating premorbid verbal intelligence in the elderly
48/100 ✓ Peer-reviewed Getting a diagnosis Journal of clinical and experimental neuropsychology
Key finding: Double cross validation showed that the model had high accuracy and stability in estimating current VIQ in nondemented subjects.
Full summary, score breakdown and related studies → Original source
October 1991 6
-
1991-10-01
Psychiatric disorders in persons with Down syndrome
48/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of nervous and mental disease
Key finding: The overall frequency of psychiatric disorders in our study population was 22.1%.
Full summary, score breakdown and related studies → Original source
-
1991-10-01
Autosomal dominant syndrome with strokelike episodes and leukoencephalopathy
41/100 ✓ Peer-reviewed Risk factors Stroke
Key finding: There appears to be a new syndrome in this family that is characterized by recurrent subcortical strokelike episodes, leukoencephalopathy, immunologic anomalies, muscular lipidosis, and an autosomal dominant pattern of transmission.
Full summary, score breakdown and related studies → Original source
-
1991-10-01
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
41/100 ✓ Peer-reviewed Risk genes beyond APOE Science (New York, N.Y.)
Key finding: Although most cases of Alzheimer's disease are sporadic, kindreds with autosomal-dominant inheritance of the syndrome suggest that a single mutation may be important in pathogenesis. +1 more finding
Full summary, score breakdown and related studies → Original source
-
1991-10-01
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
47/100 ✓ Peer-reviewed Risk genes beyond APOE Nature
Key finding: Direct sequencing of exon 17 in affected individuals from this family has revealed a base change producing a Val----Gly substitution, also at codon 717.
Full summary, score breakdown and related studies → Original source
-
1991-10-01
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
62/100 ✓ Peer-reviewed Brain tissue and pathology Annals of Neurology
Key finding: We present here both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural and neurochemical measurements performed on a prospective series of 15 patients with Alzheimer's disease and 9 neuropathologically normal subjects. +3 more findings
Full summary, score breakdown and related studies → Original source
-
1991-10-01
Ageing and Parkinson's disease: substantia nigra regional selectivity
56/100 ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology
Key finding: Regionally, the lateral ventral tier was relatively spared (2.1% loss per decade) compared with the medial ventral tier (5.4%) and the dorsal tier (6.9%). +1 more finding
Full summary, score breakdown and related studies → Original source
September 1991 2
-
1991-09-15
Postmenopausal Estrogen and Prevention Bias
67/100 ✓ Peer-reviewed Clinical trials Annals of Internal Medicine
Key finding: Brief Report15 September 1991Postmenopausal Estrogen and Prevention BiasElizabeth Barrett-Connor, MDElizabeth Barrett-Connor, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-6-455 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the last decade many investigators reported that postmenopausal women taking estrogen were at reduced risk for cardiovascular disease compared with women not taking estrogen (1). +2 more findings
Full summary, score breakdown and related studies → Original source
-
1991-09-01
Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine
36/100 ✓ Peer-reviewed Drug development Archives of internal medicine
Key finding: We used a two-round survey, based on Delphi methods, with 13 nationally recognized experts to reach consensus on explicit criteria defining the inappropriate use of medications in a nursing home population. +4 more findings
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →