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Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers
Xiaqing Jiang, Sid E O'Bryant, Robert A Rissman, Leigh A Johnson, Meredith N Braskie, Kristine Yaffe, HABS‐HD Study Team. Annals of neurology, 2026-05-04
Topic: Plasma and spinal-fluid biomarkers
Greater multimorbidity burden was associated with worse cognition and biomarkers of AD (PET amyloid standardized uptake value ratios and positivity, p-tau181, and p-tau217), neurodegeneration (neurofilament light, total tau, cortical thickness, and hippocampal volume), and SVD (white matter hyperintensity volume and presence of lacune and cerebral microbleeds). Among dementia-free individuals, higher multimorbidity burden was associated with biomarkers for greater AD pathology, neurodegeneration, and SVD. These findings support a more holistic approach to managing chronic disease burden, which has the potential to reduce overall pathophysiological burden and delay cognitive decline. ANN NEUROL 2026;100:370-379.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Jiang, X., O'Bryant, S. E., Rissman, R. A., Johnson, L. A., Braskie, M. N., Yaffe, K., et al. (2026). Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers. Annals of neurology. https://doi.org/10.1002/ana.78238
Vancouver
Jiang X, O'Bryant SE, Rissman RA, Johnson LA, Braskie MN, Yaffe K, et al. Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers. Annals of neurology. 2026. doi:10.1002/ana.78238. PMID: 42083115.
BibTeX
@article{jiang2026-42083115,
author = {Jiang, Xiaqing and O'Bryant, Sid E and Rissman, Robert A and Johnson, Leigh A and Braskie, Meredith N and Yaffe, Kristine and {HABS‐HD Study Team}},
title = {{Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers}},
journal = {Annals of neurology},
year = {2026},
doi = {10.1002/ana.78238},
pmid = {42083115},
url = {https://doi.org/10.1002/ana.78238}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Greater multimorbidity burden was associated with worse cognition and biomarkers of AD (PET amyloid standardized uptake value ratios and positivity, p-tau181, and p-tau217), neurodegeneration (neurofilament light, total tau, cortical thickness, and hippocampal volume), and SVD (white matter hyperintensity volume and presence of lacune and cerebral microbleeds).
- Among dementia-free individuals, higher multimorbidity burden was associated with biomarkers for greater AD pathology, neurodegeneration, and SVD.
- These findings support a more holistic approach to managing chronic disease burden, which has the potential to reduce overall pathophysiological burden and delay cognitive decline.
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Study details
- Participants3,808
- Evidence strengthLow
How this study scored 59/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 33 of the 56 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 3 / 4 | 3,808 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42083115) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 33 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 33 of the 56 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
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