Home › Research › Tau biomarkers
Sleep Characteristics and Cognitive Function in Older Adults Without Dementia: The CABLE Study
Yan Fu, Zuo-Teng Wang, Yi Qu, Xiao-Tong Wang, Ya-Hui Ma, Yan-Lin Bi, Qiang Dong, Lan Tan et al.. Journal of Alzheimer's disease : JAD, 2021
Topic: Brain imaging, connectivity and assessment
The Pittsburgh Sleep Quality Index (PSQI) total score was significantly negatively correlated with Montreal Cognitive Assessment (MoCA) score (p = 0.0176). Long latency (p = 0.0054) and low efficiency (p = 0.0273) were associated with cognitive impairment. Habitual nap behavior was associated with lower MoCA scores (p = 0.0045). U-shaped associations were observed between sleep habits (bedtime and nocturnal sleep duration) and cognition. A causal mediation analysis indicated that P-tau/Aβ42 mediated the association of sleep duration with cognition. These findings showed sleep characteristics were associated with cognitive functions. Sleep habits (duration, bedtime) had U-shaped associations with cognition. AD core pathologies might partially mediate the influence of sleep duration on cognitive impairments.
Key findings
- The Pittsburgh Sleep Quality Index (PSQI) total score was significantly negatively correlated with Montreal Cognitive Assessment (MoCA) score (p = 0.0176).
- Long latency (p = 0.0054) and low efficiency (p = 0.0273) were associated with cognitive impairment.
- Habitual nap behavior was associated with lower MoCA scores (p = 0.0045).
- U-shaped associations were observed between sleep habits (bedtime and nocturnal sleep duration) and cognition.
- A causal mediation analysis indicated that P-tau/Aβ42 mediated the association of sleep duration with cognition.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Participants974
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 974 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34602483) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Fu, Y., Wang, Z.-T., Qu, Y., Wang, X.-T., Ma, Y.-H., Bi, Y.-L., et al. (2021). Sleep Characteristics and Cognitive Function in Older Adults Without Dementia: The CABLE Study. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-215017
Vancouver
Fu Y, Wang Z.-T, Qu Y, Wang X.-T, Ma Y.-H, Bi Y.-L, et al. Sleep Characteristics and Cognitive Function in Older Adults Without Dementia: The CABLE Study. Journal of Alzheimer's disease : JAD. 2021. doi:10.3233/jad-215017. PMID: 34602483.
BibTeX
@article{fu2021-34602483,
author = {Fu, Yan and Wang, Zuo-Teng and Qu, Yi and Wang, Xiao-Tong and Ma, Ya-Hui and Bi, Yan-Lin and Dong, Qiang and Tan, Lan and others},
title = {{Sleep Characteristics and Cognitive Function in Older Adults Without Dementia: The CABLE Study}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2021},
doi = {10.3233/jad-215017},
pmid = {34602483},
url = {https://doi.org/10.3233/jad-215017}
}