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Risk of Alzheimer's disease and related dementia by sex and race/ethnicity: The Multiethnic Cohort Study
Unhee Lim, Songren Wang, Song-Yi Park, David Bogumil, Anna H Wu, Iona Cheng, Christopher A Haiman, Loïc Le Marchand et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021-12-09
Topic: Genetics and APOE
The ASDIR for ADRD was higher for women (17.0 per 1000 person-years) than for men (15.3) and varied across African Americans (22.9 in women, 21.5 in men), Native Hawaiians (19.3, 19.4), Latinos (16.8, 14.7), Whites (16.4, 15.5), Japanese Americans (14.8, 13.8), and Filipinos (12.5, 9.7). Similar risk patterns were observed for AD. Adjustment for education and cardiometabolic diseases attenuated the differences. Accounting for deaths from competing causes increased the sex difference, while reducing the racial/ethnic differences. Less racial/ethnic disparity was detected among apolipoprotein E (APOE) e4 carriers. More research is needed to understand the sex and racial/ethnic differences in ADRD.
Key findings
- The ASDIR for ADRD was higher for women (17.0 per 1000 person-years) than for men (15.3) and varied across African Americans (22.9 in women, 21.5 in men), Native Hawaiians (19.3, 19.4), Latinos (16.8, 14.7), Whites (16.4, 15.5), Japanese Americans (14.8, 13.8), and Filipinos (12.5, 9.7).
- Similar risk patterns were observed for AD.
- Adjustment for education and cardiometabolic diseases attenuated the differences.
- Accounting for deaths from competing causes increased the sex difference, while reducing the racial/ethnic differences.
- Less racial/ethnic disparity was detected among apolipoprotein E (APOE) e4 carriers.
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Study details
- Participants16,410
- Evidence strengthModerate
How this study scored 61/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 34 of the 56 points we could judge it on, which is 61 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 4 / 4 | 16,410 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34882963) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 34 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 34 of the 56 points we could judge it on is 61 out of 100. |
| Total | 61 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Lim, U., Wang, S., Park, S.-Y., Bogumil, D., Wu, A. H., Cheng, I., et al. (2022). Risk of Alzheimer's disease and related dementia by sex and race/ethnicity: The Multiethnic Cohort Study. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.12528
Vancouver
Lim U, Wang S, Park S.-Y, Bogumil D, Wu AH, Cheng I, et al. Risk of Alzheimer's disease and related dementia by sex and race/ethnicity: The Multiethnic Cohort Study. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022. doi:10.1002/alz.12528. PMID: 34882963.
BibTeX
@article{lim2022-34882963,
author = {Lim, Unhee and Wang, Songren and Park, Song-Yi and Bogumil, David and Wu, Anna H and Cheng, Iona and Haiman, Christopher A and Le Marchand, Loïc and others},
title = {{Risk of Alzheimer's disease and related dementia by sex and race/ethnicity: The Multiethnic Cohort Study}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2022},
doi = {10.1002/alz.12528},
pmid = {34882963},
url = {https://doi.org/10.1002/alz.12528}
}